Top 164 Alcon Jobs | SimplyHired

Principal 1, Organic Synthesis Chemistry
Alcon —Durham, NC
- Full-time
- English
- High school diploma or GED
- Doctor of Philosophy
- Health insurance
Manufacturing Associate
Alcon —Johns Creek, GA
- Full-time
- English
- High school diploma or GED
- Manufacturing
Quick Apply
Operator
Alcon —Sinking Spring, PA
- Full-time
- English
- High school diploma or GED
- Continuous improvement
Quick Apply
Associate III, Research & Development Process & Product Design
Alcon —Johns Creek, GA
- Full-time
- High school
- Engineering
- English
- Health insurance
- Paid time off
Production Technician SP
Alcon —Johns Creek, GA
- Full-time
- English
- High school diploma or GED
- No travel
Quick Apply
Alcon Rotational Leadership Program (RADAR)
Alcon —Fort Worth, TX
- Full-time
- High school
- 5 years
- English
Everest Training Coordinator
Alcon —Fort Worth, TX
- Full-time
- Classroom
- English
- Mid-level
- Health insurance
- Paid time off
Associate III, Manufacturing Production Process – Manufacturing Engineer
Alcon —Johns Creek, GA
- Full-time
- High school
- English
- High school diploma or GED
- Health insurance
- Paid time off
12d
Manufacturing Execution Systems (MES) Engineer
Alcon —Johns Creek, GA
- Full-time
- Computer Science
- High school
- English
- Health insurance
- Paid time off
Manufacturing Associate
Alcon —Johns Creek, GA
- 12 hour shift
- English
- High school diploma or GED
- Manufacturing
Quick Apply
Production Technician - Night Shift
Alcon —Johns Creek, GA
- Full-time
- English
- High school diploma or GED
- Continuous improvement
- Health insurance
- Paid time off
Quick Apply
Director, R&D Quality Assurance
Alcon —Lake Forest, CA
- $183,600 - $237,600 a year
- Full-time
- Doctoral degree
- Surgery
- High school
- Health insurance
Auto Process Machinist
Alcon —Reading, PA
- Full-time
- English
- Mid-level
- High school diploma or GED
- Health insurance
- Paid time off
Quick Apply
Sr. Manager, Quality Assurance Compliance
Alcon —Irvine, CA
- Full-time
- High school
- 5 years
- English
- Disability insurance
- Health insurance
Fall + Spring 2026-2027 Co-Op - Manufacturing Science & Technology
Alcon —Houston, TX
- Full-time
- Microsoft Outlook
- US work authorization
- SharePoint
Surveillance Auditor
Alcon —Houston, TX
- Full-time
- English
- High school diploma or GED
- Analysis skills
- Health insurance
- Paid time off
6d
Maintenance Training Specialist
Alcon —Johns Creek, GA
- Full-time
- High school
- English
- Bachelor's degree
- Health insurance
- Paid time off
Associate, Quality Assurance Engineering
Alcon —Johns Creek, GA
- Full-time
- High school
- English
- Mid-level
- Health insurance
Manufacturing Associate (K-Shift)
Alcon —Johns Creek, GA
- Full-time
- English
- High school diploma or GED
- Continuous improvement
Quick Apply
Manufacturing Associate
Alcon —Johns Creek, GA
- Full-time
- English
- High school diploma or GED
- Travel
Quick Apply

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Principal 1, Organic Synthesis Chemistry

Alcon -
Durham, NC

Apply Now

Job Details

Full-time

Benefits

Health insurance

Qualifications

English

Full Job Description

At Alcon, we're passionate about enhancing sight and helping people see brilliantly. With more than 25,000 associates, we innovate fearlessly, champion progress, and act swiftly to impact global eye health. We foster an inclusive culture, recognizing your contributions and offering opportunities to grow your career like never before. Together, we make a difference in the lives of our patients and customers. Are you ready to join us?

Alcon is looking to hire a Principal I, Organic Synthesis Chemistry, supports Alcon’s drug substance development activities from early Ideation up through Technology Transfer and Process Validation. Synthetic pathways are assessed/selected to supply drug substance for clinical and pre-clinical toxicology studies. With a view toward launch, the syntheses are developed into practical/viable routes of manufacture using principles of Quality by Design (QbD).

This role is on-site in our Durham, North Carolina location and a typical day would include:

Designs and experimentally evaluate synthetic routes for manufacture of drug candidates.
Conceives/proposes and develops new synthetic routes or methodologies.
Conducts internal and external brainstorms, evaluates and prioritizes synthetic routes.
Experimentally evaluates and proposes the final route of manufacture.
Leverages expertise in drug design, synthesis, and ADME/PK/pharmacology to provide support for ongoing and new ideation projects.
Conducts scale-up activities to supply early pre-clinical toxicology studies and/or to achieve proof of concept for manufacturing routes and processes.
Develops robust manufacturing processes using QbD principles which may include: reaction screening/profiling, confirming NOR and PAR and design of experiments (DoE), impurity fate mapping, spiking & purging, process robustness studies, and FMEAs.
Understands the importance of different crystal forms and develops chemical processes with high polymorph control.
Carries out technical transfer of chemical processes to contract manufacturing organizations (CMOs). Assists with process development, risk assessments (FMEAs), optimization, qualification, and validation of API manufacturing operations. Provides support for chemical process development and manufacturing activities at contract research and manufacturing vendors involved in the manufacture of starting materials, key raw materials, and APIs.
Addresses issues effectively and chooses an appropriate course of action/technique to obtain best results.
Translate manufacturing instructions and process development data into approvable regulatory process submissions.
Author SOPs and documents for regulatory submission
Maintains good laboratory records and summarizes results in well written reports and oral presentations.

What You’ll Bring To Alcon:

Bachelor’s Degree or Equivalent years of directly related experience (or high school +13 yrs; Assoc.+9 yrs; M.S.+2 yrs; PhD+0 yrs)
The ability to fluently read, write, understand and communicate in English
5 Years of Relevant Experience

Preferred Qualifications:

Expert synthetic organic chemist

Ph.D. in Synthetic/Organic Chemistry with 2-5 years of relevant synthetic chemistry experience (small molecule chemical synthesis/development, pharma preferred)
Good depth of knowledge/experience with synthetic methodology, chemical literature, and reaction mechanisms
Hands on experience in process scale up and technology transfer to third party.
Good understanding of process and crystallization control, physical properties, and analysis techniques (XRPD, DSC, TGA, etc.)
Ability to use/interpret mass spectral data and NMR for the purposes of structure elucidation where required.
Comfortable working in a dynamic, fast-paced environment, interacting with internal and external teams and demonstrates high degree of flexibility.
Enthusiastic and self-motivated with excellent communication (written and oral) and organizational skills
Experienced working effectively in cross-functional teams.
Working knowledge of GMP, wider CMC activities and regulatory topics including aspects of Quality by Design (QbD), technology transfer, ICH guidance, spiking/purging/specification setting preferred
Experience with high throughput/data rich experimentation techniques such as DoE
Strong mechanistic understanding of organic chemistry, and significant process development expertise and awareness of regulatory expectations and development strategies.
Experience with HPLC (Empower a plus)

How You Can Thrive at Alcon:

See your career like never before with focused growth and development opportunities
Join Alcon’s mission to provide outstanding, innovative products and solutions to improve sight, improve lives, and grow your career!
Alcon provides a robust benefits package including health, life, retirement, flexible time off and much more.
Travel up to 10%

Alcon Careers

See your impact at alcon.com/careers

ATTENTION: Current Alcon Employee/Contingent Worker

If you are currently an active employee/contingent worker at Alcon, please click the appropriate link below to apply on the Internal Career site.

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ALCON IS AN EQUAL OPPORTUNITY EMPLOYER AND PARTICIPATES IN E-VERIFY

Alcon takes pride in maintaining an inclusive environment that values different perspectives and our policies are non-discriminatory in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Alcon is also committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an email to [email protected] and let us know the nature of your request and your contact information.

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Refine Your Search

Alcon jobs

Principal 1, Organic Synthesis Chemistry

Manufacturing Associate

Operator

Associate III, Research & Development Process & Product Design

Production Technician SP

Alcon Rotational Leadership Program (RADAR)

Everest Training Coordinator

Associate III, Manufacturing Production Process – Manufacturing Engineer

Manufacturing Execution Systems (MES) Engineer

Manufacturing Associate

Production Technician - Night Shift

Director, R&D Quality Assurance

Auto Process Machinist

Sr. Manager, Quality Assurance Compliance

Fall + Spring 2026-2027 Co-Op - Manufacturing Science & Technology

Surveillance Auditor

Maintenance Training Specialist

Associate, Quality Assurance Engineering

Manufacturing Associate (K-Shift)

Manufacturing Associate

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