Top 165 Alcon Jobs | SimplyHired

Principal 1, Organic Synthesis Chemistry
Alcon —Durham, NC
- Full-time
- English
- High school diploma or GED
- Doctor of Philosophy
- Health insurance
Director, R&D Quality Assurance
Alcon —Lake Forest, CA
- $183,600 - $237,600 a year
- Full-time
- Doctoral degree
- Surgery
- High school
- Health insurance
2026 Envision R&D Rotational Program – Track 2
Alcon —Fort Worth, TX
- $68,000 - $88,000 a year
- Full-time
- Computer Science
- Continuous improvement
- US work authorization
13d
Field Reimbursement Expert Core Surgical - West
Alcon —Remote
- Full-time
- 5 years
- Medical office experience
- English
- Health insurance
Alcon Rotational Leadership Program (RADAR)
Alcon —Fort Worth, TX
- Full-time
- High school
- 5 years
- English
Vision Science - Vision Modeling Engineer
Alcon —Johns Creek, GA
- Full-time
- English
- Java
- Analysis skills
- Health insurance
Senior Field Reimbursement Expert - Retina Clinic - Central
Alcon —Remote
- Full-time
- High school
- Medical office experience
- 11+ years
- Health insurance
Director, Regulatory Affairs Strategy
Alcon —Lake Forest, CA
- Full-time
- Doctoral degree
- High school
- 11+ years
- Disability insurance
- Health insurance
Sr. Manager, Quality Assurance Compliance
Alcon —Irvine, CA
- Full-time
- High school
- 5 years
- English
- Disability insurance
- Health insurance
Surveillance Auditor
Alcon —Houston, TX
- Full-time
- English
- High school diploma or GED
- Analysis skills
- Health insurance
- Paid time off
7d
Director, General Engineering
Alcon —Houston, TX
- Full-time
- High school
- English
- Doctor of Philosophy
- Health insurance
- Paid time off
Principal Opto-Mechanical Engineer
Alcon —Lake Forest, CA
- $130,900 - $169,400 a year
- Full-time
- English
- High school diploma or GED
- Analysis skills
- Relocation assistance
- Health insurance
Director, Master Data Governance & Management
Alcon —Fort Worth, TX
- Full-time
- High school
- 11+ years
- English
- Health insurance
- Paid time off
Everest Training Coordinator
Alcon —Fort Worth, TX
- Full-time
- Classroom
- English
- Mid-level
- Health insurance
- Paid time off
Sr. Principal, Patient Safety & Experience
Alcon —Fort Worth, TX
- Full-time
- Medicine
- High school
- 11+ years
- Health insurance
Sr. Associate, Controls Engineer
Alcon —Johns Creek, GA
- Full-time
- 6 years
- High school
- System design
- Health insurance
Head of Global Surgical Communications
Alcon —Fort Worth, TX
- Full-time
- Doctoral degree
- Surgery
- 11+ years
- Relocation assistance
- Health insurance
Regulatory Affairs Manager I
Alcon —Lake Forest, CA
- $130,900 - $169,400 a year
- Full-time
- English
- High school diploma or GED
- Doctor of Philosophy
- Health insurance
- Paid time off
Sr. Optical Engineer
Alcon —Belmont, CA
- $102,850 - $133,100 a year
- Full-time
- 6 years
- High school
- English
- Health insurance
6d
Senior Package Engineer II
Alcon —Fort Worth, TX
- Full-time
- High school
- 5 years
- English
- Relocation assistance
- Flexible schedule
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Principal 1, Organic Synthesis Chemistry

Alcon -
Durham, NC

Apply Now

Job Details

Full-time

Benefits

Health insurance

Qualifications

English

Full Job Description

At Alcon, we're passionate about enhancing sight and helping people see brilliantly. With more than 25,000 associates, we innovate fearlessly, champion progress, and act swiftly to impact global eye health. We foster an inclusive culture, recognizing your contributions and offering opportunities to grow your career like never before. Together, we make a difference in the lives of our patients and customers. Are you ready to join us?

Alcon is looking to hire a Principal I, Organic Synthesis Chemistry, supports Alcon’s drug substance development activities from early Ideation up through Technology Transfer and Process Validation. Synthetic pathways are assessed/selected to supply drug substance for clinical and pre-clinical toxicology studies. With a view toward launch, the syntheses are developed into practical/viable routes of manufacture using principles of Quality by Design (QbD).

This role is on-site in our Durham, North Carolina location and a typical day would include:

Designs and experimentally evaluate synthetic routes for manufacture of drug candidates.
Conceives/proposes and develops new synthetic routes or methodologies.
Conducts internal and external brainstorms, evaluates and prioritizes synthetic routes.
Experimentally evaluates and proposes the final route of manufacture.
Leverages expertise in drug design, synthesis, and ADME/PK/pharmacology to provide support for ongoing and new ideation projects.
Conducts scale-up activities to supply early pre-clinical toxicology studies and/or to achieve proof of concept for manufacturing routes and processes.
Develops robust manufacturing processes using QbD principles which may include: reaction screening/profiling, confirming NOR and PAR and design of experiments (DoE), impurity fate mapping, spiking & purging, process robustness studies, and FMEAs.
Understands the importance of different crystal forms and develops chemical processes with high polymorph control.
Carries out technical transfer of chemical processes to contract manufacturing organizations (CMOs). Assists with process development, risk assessments (FMEAs), optimization, qualification, and validation of API manufacturing operations. Provides support for chemical process development and manufacturing activities at contract research and manufacturing vendors involved in the manufacture of starting materials, key raw materials, and APIs.
Addresses issues effectively and chooses an appropriate course of action/technique to obtain best results.
Translate manufacturing instructions and process development data into approvable regulatory process submissions.
Author SOPs and documents for regulatory submission
Maintains good laboratory records and summarizes results in well written reports and oral presentations.

What You’ll Bring To Alcon:

Bachelor’s Degree or Equivalent years of directly related experience (or high school +13 yrs; Assoc.+9 yrs; M.S.+2 yrs; PhD+0 yrs)
The ability to fluently read, write, understand and communicate in English
5 Years of Relevant Experience

Preferred Qualifications:

Expert synthetic organic chemist

Ph.D. in Synthetic/Organic Chemistry with 2-5 years of relevant synthetic chemistry experience (small molecule chemical synthesis/development, pharma preferred)
Good depth of knowledge/experience with synthetic methodology, chemical literature, and reaction mechanisms
Hands on experience in process scale up and technology transfer to third party.
Good understanding of process and crystallization control, physical properties, and analysis techniques (XRPD, DSC, TGA, etc.)
Ability to use/interpret mass spectral data and NMR for the purposes of structure elucidation where required.
Comfortable working in a dynamic, fast-paced environment, interacting with internal and external teams and demonstrates high degree of flexibility.
Enthusiastic and self-motivated with excellent communication (written and oral) and organizational skills
Experienced working effectively in cross-functional teams.
Working knowledge of GMP, wider CMC activities and regulatory topics including aspects of Quality by Design (QbD), technology transfer, ICH guidance, spiking/purging/specification setting preferred
Experience with high throughput/data rich experimentation techniques such as DoE
Strong mechanistic understanding of organic chemistry, and significant process development expertise and awareness of regulatory expectations and development strategies.
Experience with HPLC (Empower a plus)

How You Can Thrive at Alcon:

See your career like never before with focused growth and development opportunities
Join Alcon’s mission to provide outstanding, innovative products and solutions to improve sight, improve lives, and grow your career!
Alcon provides a robust benefits package including health, life, retirement, flexible time off and much more.
Travel up to 10%

Alcon Careers

See your impact at alcon.com/careers

ATTENTION: Current Alcon Employee/Contingent Worker

If you are currently an active employee/contingent worker at Alcon, please click the appropriate link below to apply on the Internal Career site.

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ALCON IS AN EQUAL OPPORTUNITY EMPLOYER AND PARTICIPATES IN E-VERIFY

Alcon takes pride in maintaining an inclusive environment that values different perspectives and our policies are non-discriminatory in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Alcon is also committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an email to [email protected] and let us know the nature of your request and your contact information.

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Refine Your Search

Alcon jobs

Principal 1, Organic Synthesis Chemistry

Director, R&D Quality Assurance

2026 Envision R&D Rotational Program – Track 2

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Alcon Rotational Leadership Program (RADAR)

Vision Science - Vision Modeling Engineer

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Director, Regulatory Affairs Strategy

Sr. Manager, Quality Assurance Compliance

Surveillance Auditor

Director, General Engineering

Principal Opto-Mechanical Engineer

Director, Master Data Governance & Management

Everest Training Coordinator

Sr. Principal, Patient Safety & Experience

Sr. Associate, Controls Engineer

Head of Global Surgical Communications

Regulatory Affairs Manager I

Sr. Optical Engineer

Senior Package Engineer II

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