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Head of Peptide Drug Discovery
CALICO —South San Francisco, CA
- $320,000 - $350,000 a year
- Management
- 11+ years
- Doctor of Philosophy
Scientist, Peptide Chemistry
CALICO —South San Francisco, CA
- $135,000 - $145,000 a year
- Analysis skills
- Doctor of Philosophy
- Team management
Head, Research
CALICO —South San Francisco, CA
- $314,000 - $360,000 a year
- Medicine
- Management
- 11+ years
Principal Scientist, Antibody Engineering & Rational Design
CALICO —South San Francisco, CA
- $198,000 - $241,000 a year
- 8 years
- Doctor of Philosophy
- Senior level
Postdoctoral Fellow, Hahn Lab - Brain Aging
CALICO —South San Francisco, CA
- $95,000 a year
- Local
- Analysis skills
- Presentation skills
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Machine Learning / Senior Machine Learning Scientist / Engineer
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Analysis skills
- Doctor of Philosophy
Postdoctoral Fellow, Jan Lab - Parkinson's Disease
CALICO —South San Francisco, CA
- $95,000 a year
- Analysis skills
- Presentation skills
- Doctor of Philosophy
Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling
CALICO —South San Francisco, CA
- $160,000 - $197,000 a year
- 3 years
- Analysis skills
- Doctor of Philosophy
Machine Learning Scientist / Senior Machine Learning Scientist
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Doctor of Philosophy
- In-person
Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology
CALICO —South San Francisco, CA
- $95,000 a year
- Analysis skills
- Presentation skills
- Doctor of Philosophy
Senior Director, Contracts, Alliances and Intellectual Property
CALICO —South San Francisco, CA
- $295,000 - $310,000 a year
- Analysis skills
- Bachelor's degree
- Doctor of Philosophy
Medical Director / Senior Medical Director
CALICO —South San Francisco, CA
- $374,000 - $435,000 a year
- Medicine
- English
- Doctor of Philosophy
Data Engineer, Human Cohorts
CALICO —South San Francisco, CA
- $191,000 - $195,000 a year
- Azure
- Computer Science
- Bachelor of Science
Associate Director/Director, In Vivo Physiology
CALICO —South San Francisco, CA
- $215,000 - $265,000 a year
- Management
- Analysis skills
- Doctor of Philosophy
Associate Director, Medical Writing
CALICO —South San Francisco, CA
- $230,000 - $240,000 a year
- Master's degree
- 8 years
- Doctor of Philosophy
Director, Regulatory CMC
CALICO —South San Francisco, CA
- $275,000 - $280,000 a year
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
Server
Calico —Easthampton, MA
- $25 - $50 an hour
- Full-time
- Serving
- Mid-level
- Fair chance
- Employee discount
- Food provided
Quick Apply
Director, Regulatory Affairs
CALICO —South San Francisco, CA
- $275,000 - $280,000 a year
- Full-time
- Office
- Master's degree
- Doctor of Philosophy
Associate Director, External Communications
CALICO —South San Francisco, CA
- $195,000 - $200,000 a year
- Office
- Senior level
- Communication skills

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Head of Peptide Drug Discovery

CALICO -
South San Francisco, CA

Apply Now

Job Details

$320,000 - $350,000 a year

Qualifications

Biotechnology
Records maintenance
Doctoral degree in chemistry
Formulation chemistry
Doctor of Chemistry
Medicinal chemistry
Doctor of Philosophy
Scientific writing
Pharmaceutical company experience
Pharmaceutical research experience
Cross-functional communication

Full Job Description

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

Calico is seeking an accomplished and motivated individual to lead peptide drug discovery efforts as Head of Peptide Drug Discovery within the Calico Drug Discovery organization. This leader will collaborate with innovative and diverse scientists and play a pivotal role in advancing Calico’s Preclinical pipeline to deliver oral peptide drug candidates to our development portfolio. The ideal candidate will leverage deep and proven expertise in the lead optimization of oral peptide drug candidates, provide leadership for discovery and development stage projects, and be an effective people leader capable of attracting key talent and developing our internal team of peptide drug discovery scientists.

Responsibilities:

Act as a peptide drug discovery Subject Matter Expert (SME) to deliver peptide Drug Candidates for the Calico pipeline
Be a strong and collaborative partner with leaders of the Calico Small Molecule Drug Discovery, Machine Learning Platform, Discovery Technologies, Research, CMC, DMPK, Toxicology and Clinical Development functions
Bridge Computation & Chemistry: Serve as the primary technical liaison and advisor to the ML team, ensuring chemical intuition effectively informs algorithmic design and vice versa
Provide leadership, mentorship, and development of the existing peptide chemistry team to achieve a cutting-edge peptide drug discovery group
Maintain oversight of external CROs to support chemistry, formulation, and DMPK for peptide drug discovery
Contribute to global regulatory submissions (e.g., IBs, Briefing Books, INDs, NDAs)
Represent Calico in external scientific collaborations, committees, and consortia in the field of peptide drug discovery

Position Requirements:

PhD in organic/peptide/medicinal chemistry with 12+ years of drug discovery experience in biotech or pharma
Proven track record of successfully delivering peptide drug candidates that have achieved preclinical candidate nomination and progressed into clinical development
Effective communication with ML-peptide design team to deliver prioritized design concepts through strong collaboration
Strong working knowledge of the synthesis of peptide libraries and the scale-up of peptide lead molecules
Strong organic chemistry skills to direct the synthesis of non-canonical amino acids
Deep knowledge in the use of formulation excipients to enhance oral bioavailability of peptide drug candidates
Self-motivated, enthusiastic, and highly adaptable with the ability to quickly identify project challenges and pivot strategies in a fast-paced environment
Exceptional oral communication and writing skills, with record-keeping and data organization skills
Must be willing to work onsite 5 days a week

Nice to Have:

Experience with evaluation of AI/ML generated peptides in Hit Generation-Lead Optimization

The estimated base salary range for this role is $320,000 - $350,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Apply Now

Refine Your Search

calico jobs

Head of Peptide Drug Discovery

Scientist, Peptide Chemistry

Head, Research

Principal Scientist, Antibody Engineering & Rational Design

Postdoctoral Fellow, Hahn Lab - Brain Aging

Principal Scientist, Process Chemistry

Machine Learning / Senior Machine Learning Scientist / Engineer

Postdoctoral Fellow, Jan Lab - Parkinson's Disease

Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling

Machine Learning Scientist / Senior Machine Learning Scientist

Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology

Senior Director, Contracts, Alliances and Intellectual Property

Medical Director / Senior Medical Director

Data Engineer, Human Cohorts

Associate Director/Director, In Vivo Physiology

Associate Director, Medical Writing

Director, Regulatory CMC

Server

Director, Regulatory Affairs

Associate Director, External Communications

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