Top 159 Merck Group Jobs

Scientist - Oligonucleotide Biology
Merck KGaA —Billerica, MA
- $95,900 - $143,800 a year
- Master's degree
- Doctor of Philosophy
- Neurology
- Health insurance
- Paid time off
Process Development Scientist New England - Remote
Merck KGaA —Burlington, MA
- $77,500 - $116,500 a year
- Remote
- Engineering
- Mid-level
- 3 years
- Health insurance
- Paid time off
11d
Director Functional Genomics (Billerica MA)
Merck KGaA —Billerica, MA
- $182,600 - $274,000 a year
- Engineering
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Paid time off
Senior Scientist - Oligo Bioinformatics
Merck KGaA —Billerica, MA
- $112,800 - $169,200 a year
- 3 years
- Doctor of Philosophy
- Neurology
- Opportunities for advancement
Scientist I/II, Bioanalytical (LC-MS)
Tessera Therapeutics —Somerville, MA
- $109,000 - $143,000 a year
- Bachelor of Science
- Doctor of Philosophy
- Communication skills
- Disability insurance
- Health insurance
BioAnalytical Scientist 1
MilliporeSigma —Bedford, MA
- $32 - $38 an hour
- Full-time
- Mid-level
- Analysis skills
- US work authorization
Quick Apply
13d
Scientist, Pharmacology
Merck —San Francisco, CA
- $89,000 - $140,100 a year
- Full-time
- Mid-level
- 3 years
- Bachelor's degree
- Paid holidays
- Health insurance
Senior Scientist, Biocatalysis
Merck —Rahway, NJ
- $117,000 - $184,200 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
11d
Executive Director, Head of LNP Discovery Biology
Merck KGaA —Billerica, MA
- $237,300 - $355,900 a year
- 11+ years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Paid time off
Senior Scientist, Protein Expression
Merck —San Francisco, CA
- $131,400 - $206,800 a year
- Full-time
- Bachelor of Science
- Analysis skills
- Bachelor's degree
- Paid holidays
- Health insurance
7d
Senior Scientist, Computational Safety & Exploratory Pharmacology
Merck —West Point, PA
- $106,200 - $167,200 a year
- Full-time
- Analysis skills
- Bachelor's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
4d
Global Blood Typing and Antibody Specialist (Remote)
Merck KGaA —Burlington, MA
- $94,700 - $170,500 a year
- Up to 50% travel
- 5 years
- Master's degree
- Health insurance
- Paid time off
8d
Principal Scientist, Materials Science
Merck —Rahway, NJ
- $156,900 - $247,000 a year
- Full-time
- Master's degree
- 8 years
- Analysis skills
- Paid holidays
- Health insurance
Associate Principal Scientist, Analytical R&D
Merck —Rahway, NJ
- $142,400 - $224,100 a year
- Full-time
- 3 years
- Master's degree
- Analysis skills
- Paid holidays
- Health insurance
13d
Senior Specialist, Data Science
Merck —San Francisco, CA
- $129,000 - $203,100 a year
- Full-time
- Computer Science
- 3 years
- AWS
- Paid holidays
- Health insurance
Scientist, Assay Development (Onsite)
Merck —West Point, PA
- $87,300 - $137,400 a year
- Full-time
- Bachelor of Science
- Writing skills
- Mid-level
- Paid holidays
- Health insurance
5d
Principal Scientist, Vaccine Drug Product Development
Merck —West Point, PA
- $173,200 - $272,600 a year
- Full-time
- Bachelor of Science
- 8 years
- Bachelor's degree
- Paid holidays
- Health insurance
4d
Principal Scientist, Long-Acting Injectable Sterile Product Development
Merck —Rahway, NJ
- $173,200 - $272,600 a year
- Full-time
- 7 years
- Management
- Bachelor of Science
- Paid holidays
- Health insurance
12d
Corporate Counsel - Discovery Solutions Commercial Americas
Merck KGaA —Burlington, MA
- $158,800 - $238,100 a year
- Office
- Business development experience
- Travel
- Health insurance
- Paid time off
Scientist 2, Microbiology
EMD-Merck US —Bedford, MA
- Full-time
- Mid-level
- 1 year
- Communication skills
Quick Apply

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Scientist - Oligonucleotide Biology

Merck KGaA -
Billerica, MA

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Job Details

$95,900 - $143,800 a year

Benefits

Health insurance
Paid time off
Opportunities for advancement

Qualifications

Optimizing workflow processes
Safe work practices
Biology
Drug development research projects
Advanced cell culture techniques
Experimental data reports
Laboratory project records management
Immunological assays
Molecular Biology
Biochemistry
Laboratory safety
GLP
Doctorate in Pharmacology
Molecular biomarkers
Scientific publications
Automation
Master's degree in molecular biology
Immunological laboratory techniques
Design of experiments
Presentations for conferences or internal meetings
Leading laboratory workflow efficiency optimizations
Master's degree in Biochemistry
Flow cytometers
Advanced microscopy techniques
Assay development
Cell Biology
Master's degree
Collaborative research
Laboratory reports
Doctor of Philosophy

Full Job Description

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

The Oligonucleotide Therapeutics group is seeking a highly motivated and collaborative Scientist to support the discovery, characterization, and optimization of oligonucleotide therapeutics across a range of disease areas. This role is intended for an experimental molecular and cellular biologist who combines a strong foundation in RNA biology with hands-on experience in cell-based assay development, mechanistic studies, and translational research. In this role, you will help advance novel oligonucleotide therapeutics from early discovery toward preclinical development by developing robust in vitro assays, generating high-quality biological data, and contributing to the selection of next-generation therapeutic candidates.

You will be responsible for designing, executing, and optimizing cellular and molecular biology workflows to evaluate oligonucleotide activity, including target engagement, mRNA knockdown, protein modulation, and mechanism of action. You will establish quantitative molecular biology workflows, optimize cell-based assay platforms, and apply data-driven insights to support candidate prioritization and translational decision-making. Working closely with chemistry, formulation, and translational research teams, you will help evaluate novel oligonucleotide sequences, chemical modifications, and delivery strategies while contributing to the advancement of our oligonucleotide therapeutic platform.

Responsibilities:

Design, execute, and optimize in vitro assays to evaluate oligonucleotide (ASO, siRNA, LNA) activity, including target engagement, mRNA knockdown, protein modulation, and splice-switching in disease-relevant cell models.
Establish, optimize, and validate molecular biology workflows including RT-qPCR, Western blotting, flow cytometry, immunofluorescence microscopy, and other cell-based assays to support therapeutic discovery.
Develop and characterize cellular models to assess oligonucleotide uptake, intracellular trafficking, pharmacodynamic responses, and mechanism of action.
Perform dose-response and time-course studies to evaluate oligonucleotide potency, durability, and pharmacological activity.
Analyze experimental data, identify trends, troubleshoot technical challenges, and recommend next-step experiments to advance lead optimization.
Collaborate with multidisciplinary teams, including chemistry, formulation, and bioinformatics, to evaluate oligonucleotide sequences, chemical modifications, and delivery strategies.
Support implementation of laboratory automation and high-throughput workflows to improve assay robustness, reproducibility, and efficiency.
Maintain accurate experimental records and document procedures, results, and conclusions in accordance with internal standards and good laboratory practices.
Present scientific findings at project team meetings and contribute to internal reports, scientific presentations, and publications.
Maintain a safe, organized laboratory environment while adhering to company safety policies and laboratory best practices.

Who You Are:

Minimum Qualifications:

PhD in Molecular Biology, Cell Biology, RNA Biology, Biochemistry, Pharmacology, or other Scientific discipline with 1+ years of experience with oligonucleotide therapeutics, including ASOs, siRNA, miRNA, splice-switching oligonucleotides, or similar RNA-targeting technologies

Master’s degree in Molecular Biology, Cell Biology, RNA Biology, Biochemistry, Pharmacology, or other Scientific discipline with 3+ years of experience with oligonucleotide therapeutics, including ASOs, siRNA, miRNA, splice-switching oligonucleotides, or similar RNA-targeting technologies

Preferred Qualifications:

Experience culturing and maintaining mammalian cell lines and developing robust cell-based assays for therapeutic discovery
Strong experience developing and executing cell-based assays to evaluate target engagement, gene expression, and pharmacodynamic endpoint
Proficiency in molecular and cellular biology techniques including RT-qPCR, Western blotting, ddPCR, ELISA/MSD immunoassays, flow cytometry, fluorescence microscopy, and mammalian cell culture
Experience designing, optimizing, and executing medium- to high-throughput cell-based screening assays using multiple mammalian cell lines to evaluate oligonucleotide potency, target engagement, and pharmacodynamic responses
Familiarity with oligonucleotide chemical modifications, delivery technologies, and mechanism-of-action studies
Experience with laboratory automation, high-throughput screening, or Design of Experiments (DoE)
Knowledge of translational biomarkers, pharmacodynamic assays, and target engagement strategies
Demonstrated ability to independently design experiments, analyze complex datasets, troubleshoot technical challenges, and communicate scientific findings
Excellent organizational, written, and verbal communication skills
Ability to work effectively in a collaborative, cross-functional research environment

Pay Range for this position: $95,900 - $143,800

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!

Apply Now

Refine Your Search

Merck Group jobs

Scientist - Oligonucleotide Biology

Process Development Scientist New England - Remote

Director Functional Genomics (Billerica MA)

Senior Scientist - Oligo Bioinformatics

Scientist I/II, Bioanalytical (LC-MS)

BioAnalytical Scientist 1

Scientist, Pharmacology

Senior Scientist, Biocatalysis

Executive Director, Head of LNP Discovery Biology

Senior Scientist, Protein Expression

Senior Scientist, Computational Safety & Exploratory Pharmacology

Global Blood Typing and Antibody Specialist (Remote)

Principal Scientist, Materials Science

Associate Principal Scientist, Analytical R&D

Senior Specialist, Data Science

Scientist, Assay Development (Onsite)

Principal Scientist, Vaccine Drug Product Development

Principal Scientist, Long-Acting Injectable Sterile Product Development

Corporate Counsel - Discovery Solutions Commercial Americas

Scientist 2, Microbiology

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