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Scientist, Peptide Chemistry
CALICO —South San Francisco, CA
- $135,000 - $145,000 a year
- Analysis skills
- Doctor of Philosophy
- Team management
Head of Peptide Drug Discovery
CALICO —South San Francisco, CA
- $320,000 - $350,000 a year
- Management
- 11+ years
- Doctor of Philosophy
Machine Learning / Senior Machine Learning Scientist / Engineer
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Analysis skills
- Doctor of Philosophy
Machine Learning Scientist / Senior Machine Learning Scientist
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Doctor of Philosophy
- In-person
Principal Scientist, Antibody Engineering & Rational Design
CALICO —South San Francisco, CA
- $198,000 - $241,000 a year
- 8 years
- Doctor of Philosophy
- Senior level
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling
CALICO —South San Francisco, CA
- $160,000 - $197,000 a year
- 3 years
- Analysis skills
- Doctor of Philosophy
Postdoctoral Fellow, Hahn Lab - Brain Aging
CALICO —South San Francisco, CA
- $95,000 a year
- Local
- Analysis skills
- Presentation skills
Postdoctoral Fellow, Jan Lab - Parkinson's Disease
CALICO —South San Francisco, CA
- $95,000 a year
- Analysis skills
- Presentation skills
- Doctor of Philosophy
Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology
CALICO —South San Francisco, CA
- $95,000 a year
- Analysis skills
- Presentation skills
- Doctor of Philosophy
Senior Director, Contracts, Alliances and Intellectual Property
CALICO —South San Francisco, CA
- $295,000 - $310,000 a year
- Analysis skills
- Bachelor's degree
- Doctor of Philosophy
Data Engineer, Human Cohorts
CALICO —South San Francisco, CA
- $191,000 - $195,000 a year
- Azure
- Computer Science
- Bachelor of Science
Medical Director / Senior Medical Director
CALICO —South San Francisco, CA
- $374,000 - $435,000 a year
- Medicine
- English
- Doctor of Philosophy
Associate Director, Medical Writing
CALICO —South San Francisco, CA
- $230,000 - $240,000 a year
- Master's degree
- 8 years
- Doctor of Philosophy
Associate Director/Director, In Vivo Physiology
CALICO —South San Francisco, CA
- $215,000 - $265,000 a year
- Management
- Analysis skills
- Doctor of Philosophy
Director, Regulatory CMC
CALICO —South San Francisco, CA
- $275,000 - $280,000 a year
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
Associate Director, External Communications
CALICO —South San Francisco, CA
- $195,000 - $200,000 a year
- Office
- Senior level
- Communication skills
Director, Regulatory Affairs
CALICO —South San Francisco, CA
- $275,000 - $280,000 a year
- Full-time
- Office
- Master's degree
- Doctor of Philosophy
In Home Caregiver for MINORS
Calico Home Care, llc —Aurora, CO
- $19 - $21 an hour
- Part-time
- Heavy lifting
- Clean MVR report
- Home Health
- Paid training
- Health insurance
Quick Apply
2d
Tax and Compliance Associate (part-time)
Everfast, Inc. /Calico —Kennett Square, PA
- $25 - $30 an hour
- Part-time
- Research
- Office
- Administrative experience
Quick Apply
14d

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Scientist, Peptide Chemistry

CALICO -
South San Francisco, CA

Apply Now

Job Details

$135,000 - $145,000 a year

Qualifications

Pharmaceutical synthesis
High-performance liquid chromatographs
Simulation modeling (chemistry)
Formulation chemistry
Assay development
Doctor of Philosophy
Cross-functional collaboration
Automated liquid handling systems
Pharmaceutical research experience
Cross-functional communication
Drug formulation
Nuclear magnetic resonance (NMR) spectroscopy
Molecular analysis

Full Job Description

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

We are seeking a scientist to join our Peptide Chemistry team. In this role, you will drive peptide drug discovery projects that sit at the nexus of empirical medicinal chemistry and Calico’s proprietary Machine Learning (ML) peptide design platform. You will collaborate cross-functionally with ML scientists, medicinal chemists, automation specialists, and biologists to explore structure-activity relationships (SAR). By leveraging a rapid design-make-test cycle, you will accelerate the optimization of therapeutic peptides and contribute to the evolution of a world-class synthetic engine.

Key Responsibilities:

Drive Discovery: Lead peptide drug discovery campaigns from initial hit identification through to IND-enabling studies
Innovate Synthetic Workflows: Onboard and optimize novel chemistries for high-throughput, automated peptide synthesis; troubleshoot complex synthetic challenges to generate high-quality leads, and curate a custom library of building blocks
Cross-Functional Partnership: Collaborate with biology, software, automation, assay, and pharmacology teams to ensure seamless execution of ML platform objectives and drug discovery milestones
Mentorship and Management: Actively mentor junior scientists, fostering a culture of technical excellence, continuous learning, and collaborative innovation
Manage external collaborations and CROs efficiently, including teams of chemists, DMPK scientists and formulation experts

Position Requirements:

Ph.D. in Organic Chemistry, Peptide Chemistry, or a related discipline with 0-2 years of industry experience in drug discovery
Experience in peptide hit discovery, SAR campaigns, ADMET optimization, and peptide formulation
Proven experience building and interpreting complex assay cascades, including biophysical characterization, functional protein/cell-based assays, and ADMET screening
High proficiency in automated synthesis, purification (HPLC, Flash, SPE), and characterization (LCMS, NMR, CD, etc.)
Demonstrated ability to implement diverse chemistries, including backbone-modifications, macrocyclization, stapling, and bioconjugation via solid- or solution-phase strategies
Excellent problem-solving and analytical skills
Exceptional interpersonal and communication skills for effective collaboration across diverse functional groups
Must be willing to work onsite 5 days per week

Nice to Have:

Experience with organic synthesis, including transition metal catalysis and synthesis of non-canonical amino acids, is highly desired
Experience with automation, software, and data-science integration into chemistry workflows
Ability to utilize AI-tools to improve efficiency of research and build programs for data analysis or synthesis
Knowledgeable on the key principles of ML-design for peptide therapeutics
Prior experience with peptide-specific computational tools for hit discovery, SAR prioritization, molecular modeling, and physicochemical characterization

The estimated base salary range for this role is $135,000 - $145,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Apply Now

Refine Your Search

calico jobs

Scientist, Peptide Chemistry

Head of Peptide Drug Discovery

Machine Learning / Senior Machine Learning Scientist / Engineer

Machine Learning Scientist / Senior Machine Learning Scientist

Principal Scientist, Antibody Engineering & Rational Design

Principal Scientist, Process Chemistry

Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling

Postdoctoral Fellow, Hahn Lab - Brain Aging

Postdoctoral Fellow, Jan Lab - Parkinson's Disease

Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology

Senior Director, Contracts, Alliances and Intellectual Property

Data Engineer, Human Cohorts

Medical Director / Senior Medical Director

Associate Director, Medical Writing

Associate Director/Director, In Vivo Physiology

Director, Regulatory CMC

Associate Director, External Communications

Director, Regulatory Affairs

In Home Caregiver for MINORS

Tax and Compliance Associate (part-time)

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