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Senior Research Associate/ Research Scientist

Zafrens
San Diego, CA

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Job Details

Full-time
$85,000 - $110,000 a year
9 days ago

Benefits

Health insurance
Dental insurance
401(k)
Vision insurance

Qualifications

Biology
Records maintenance
Biochemistry
Bachelor of Science
Assay development
Biochemical laboratory techniques
Bachelor's degree
Organizational skills
Pharmaceutical research experience
Statistical analysis tools

Full Job Description

About the Role

We are seeking a highly motivated and technically skilled Senior Research Assistant to join our Drug Discovery team. In this role, you will design, execute, and analyze cell-based and in vivo studies that drive our early-stage discovery pipeline from target validation through lead optimization. The ideal candidate is hands-on at the bench, rigorous with data, and comfortable owning experiments end-to-end with minimal supervision.

Key Responsibilities

Biochemical assays: Design and perform biochemical assays to evaluate compound potency and drive SAR development for internal pipeline projects.
Cell-based assays: Design and perform proliferation, viability, cytotoxicity, reporter, and functional assays to evaluate compound potency and mechanism of action.
Potency analysis (IC50/EC50): Generate dose-response curves and calculate IC50 / EC50 / GI50 values using GraphPad Prism or equivalent, and interpret potency and selectivity data for the project team.
Cell culture: Maintain and expand mammalian cell lines (adherent and suspension), including thawing, passaging, cryopreservation, mycoplasma testing, and QC of cell banks.
Develop, optimize, and validate new assays; troubleshoot experimental issues and improve throughput and reproducibility.
Analyze, interpret, and clearly present experimental data at team meetings; maintain accurate, timely records in an electronic lab notebook (ELN).
Collaborate cross-functionally with medicinal chemistry, pharmacology, and biology colleagues to advance compounds through the pipeline.
Contribute to protocol writing, SOP development and general lab equipment maintenance.

Required Qualifications

Bachelor's or Master's degree in Biology, Biochemistry, Pharmacology, Cell Biology, or a related life-science field.
Typically 5-10+ years (BS) or 5+ years (MS) of hands-on laboratory experience in drug discovery, biotech, pharma, or an academic research setting.
Demonstrated expertise in biochemical and cell-based assay execution. Strong abilities in troubleshooting.
Proficiency in IC50/EC50 determination and dose-response data analysis (GraphPad Prism or equivalent).
Solid understanding of drug discovery and development concepts.
Excellent organizational skills, attention to detail, and accurate record-keeping.

Preferred Qualifications

Experience with high-throughput or high-content screening.
Familiarity with flow cytometry, Western blotting, qPCR, ELISA, or immunofluorescence.
Prior work in a specific therapeutic area (e.g., oncology, immunology, neuroscience).
Working knowledge of statistical analysis and data visualization.

Pay: $85,000.00 - $110,000.00 per year

Benefits:

401(k)
Dental insurance
Health insurance
Vision insurance

Work Location: In person

Quick Apply

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