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Sr. Engineer – DSP

DMC Biotechnologies, Inc.
Boulder, CO

Quick Apply

Job Details

Full-time
$125,000 - $155,000 a year

Qualifications

Research design
Laboratory experiment design
Design of experiments
Technical writing experience within manufacturing
Bioprocessing
Risk assessment
Handling small molecules
Data analysis software

Full Job Description

The Role

We are seeking a Chemical Engineer to join our Downstream Processing (DSP) Development team, focused on bench-scale process development for biologics/bioproducts and the translation of those processes to pilot and commercial manufacturing. You will design and execute experiments at bench scale (e.g., mL–L), develop robust purification steps (chromatography, filtration, precipitation, etc.), and work cross-functionally to transfer your process to industrial scale.

This role is ideal for an engineer who enjoys hands-on lab work, rigorous data analysis, and solving scale-up challenges with the end goal of commercializing processes at industrial scale. Traveling to partner sites for troubleshooting and overseeing tech-transfer is likely.

The anticipated base salary for this role is $125,000 – $155,000 per year. Final compensation will be determined based on experience, skills, and geographic location, and may include bonus eligibility and a full benefits package.

Key Responsibilities

Bench-scale process development and optimization.
Design, execute, and analyze experiments using purification unit operations (e.g., depth filtration, centrifugation, TFF/UFDF, chromatography, precipitation, etc.).
Build methods and strategies to define scalable operating ranges, identify critical process parameters, and improve yield, purity, and throughput for purification unit operations.
Support tech transfer to internal or external manufacturing sites, including documentation, protocols, and general transfer of process knowledge.
Translate bench-scale findings into continuous models to predict process flow rates, unit sizes, and overall process costs.
Author and review development reports, batch records, protocols, and technical assessments to enable stage gates
Maintain high standards for data integrity, traceability, and reproducibility; ensure experiments and documentation align with internal quality systems and regulatory expectations.
Collaborate with Upstream, Analytical, Quality, Regulatory, and Business teams to ensure end-to-end process performance and timeline execution.
Communicate results clearly in team meetings and technical reviews; present recommendations backed by data and risk-based reasoning.

Required Qualifications

B.S. or higher in Chemical Engineering, Biochemical Engineering, Bioengineering, or a related discipline.
5+ years (B.S.) or 0–2 years (M.S./Ph.D.) of relevant experience in small molecule purifications, bioprocessing, or process development (industry or strong graduate/lab experience).
Hands-on experience with one or more of the following:
- Chromatography (resin screening, column packing, scale-down models)
- TFF/UFDF systems (membrane selection, flux optimization, shear sensitivity, fouling mitigation)
- Crystallization (solubility studies, process design, solid-liquid-separation methods)
- Continuous process modeling (using advanced software packages or manually)
Proficiency in experimental design and data analysis (Python, R, Excel, etc.)
Strong technical writing skills

Preferred Qualifications

Experience with scale-up/tech transfer and/or supporting manufacturing campaigns.
Knowledge of process characterization, risk assessment (FMEA), and concepts such as QbD.
Availability to travel
Experience developing cost-of-goods (COGs) awareness and capacity/throughput assessments.
Comfort with lab safety practices, equipment maintenance, and methodical troubleshooting.

Quick Apply

Refine Your Search

Engineer General jobs

Sr. Engineer – DSP

Validation Engineer

Senior Process Development Engineer

Entry Level Manufacturing Engineer

Quality Engineer (General)

Nanofabrication Process Engineer

R&D Engineer I

Process Engineer I

Junior Engineer

Applications Engineer

Production Engineer (General)

General Engineer

Process Engineer

Process Engineer

Industrial Engineer

Process Engineer (General)

MES Engineer

Equipment Engineer (General)

MECHANICAL, INDUSTRIAL, OR GENERAL ENGINEER

Project Engineer (US Citizenship required)

I want to receive the latest job alert for Engineer General

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