Top 85 Engineer Protein Purification Jobs

Scientist, Protein Engineer
Trutino Biosciences —San Diego, CA
- Full-time
- Doctor of Philosophy
- Mentoring
- Senior level
Associate Scientist, Protein Engineering & Binder Optimization
Kite Pharma —Foster City, CA
- $109,650 - $141,900 a year
- Full-time
- Mid-level
- Master's degree
- Bachelor's degree
- Health insurance
- Dental insurance
Process Development Engineer I, Purification Development
Regeneron —Tarrytown, NY
- $80,300 - $131,100 a year
- Full-time
- Engineering
- Master's degree
- Bachelor's degree
- Health insurance
- Dental insurance
Junior/Assistant/Associate/Full Specialist (Neuroscience and Protein Engineering)
UC San Francisco Academic —San Francisco, CA
- $55,000 - $194,800 a year
- Online Application
- Doctoral degree
- Master's degree
- University
Scientist / Senior Scientist, Protein Engineering
Kodiak Sciences Inc. —Palo Alto, CA
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
Senior Scientist - Downstream Process Development, mRNA
Catalent —Madison, WI
- Email
- Doctoral degree
- Master's degree
- Bachelor's degree
- Paid holidays
- Health insurance
Scientist - Protein Engineering
Kaigene —Rockville, MD
- Part-time
- Doctor of Philosophy
- Communication skills
- Entry level
Scientist – Protein Engineering – Organic Chemist: ADC Research & Development
Amgen —Thousand Oaks, CA
- $111,695.10 - $151,116.90 a year
- Doctoral degree
- Mid-level
- Master's degree
- Disability insurance
- Health insurance
Viral Vector Engineer
Neion Bio —New York, NY
- $90,000 - $130,000 a year
- Full-time
- Research
- Bachelor's degree
- Doctor of Philosophy
- Health insurance
- Dental insurance
Quick Apply
Scientist/Sr Scientist, Protein Engineering
Earli, Inc. —San Francisco, CA
- $110,000 - $145,000 a year
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
Research Scientist/Engr 4
University of Washington —Seattle, WA
- $99,444 - $122,124 a year
- Full-time
- Master's degree
- University
- Senior level
Purification Development Scientist (Philadelphia)
Genentech —Philadelphia, PA
- $91,000 - $169,000 a year
- Online Application
- Bachelor of Science
- Mid-level
- Bachelor's degree
Consultant, biologics CMC process development
Bionyra Pharma —Remote
- $120 - $300 an hour
- Part-time
- Remote
- 5 years
- Doctor of Philosophy
- Senior level
Quick Apply
8d
Scientist / Engineer I, R&D
Cytiva —Marlborough, MA
- $75,000 - $90,000 a year
- Full-time
- Travel
- Organizational skills
- In-person
- Health insurance
- Dental insurance
Research Scientist/Engr Assistant
University of Washington —Seattle, WA
- $56,400 - $70,800 a year
- Full-time
- Bachelor's degree
- Team management
- Quality control
Research Scientist/Engr 1
University of Washington —Seattle, WA
- $56,448 - $58,008 a year
- Full-time
- University
- Bachelor's degree
- Computer skills
Automated Antibody Engineering Scientist
IDEXX —Westbrook, ME
- From $90,000 a year
- Full-time
- 3 years
- Master's degree
- Analysis skills
- Health insurance
- Dental insurance
7d
Process Development Engineer III, Purification Development (PMPD)
Regeneron —Tarrytown, NY
- $109,900 - $179,300 a year
- Bachelor of Science
- Bachelor's degree
- Continuous improvement
- Health insurance
- Dental insurance
Chromatography Expert
MilliporeSigma —San Diego, CA
- $85,300 - $187,700 a year
- Full-time
- 5 years
- Bachelor of Science
- Bachelor's degree
- Health insurance
- Paid time off
Research Assistant IV (Molecular Biology and Protein Engineering)
The Scripps Research Institute —San Diego, CA
- $75,000 - $93,750 a year
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Free parking
- Health savings account

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Scientist, Protein Engineer

Trutino Biosciences
San Diego, CA

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Job Details

Full-time

Qualifications

Advanced cell culture techniques
DNA analysis
Protein analysis (analytical chemistry specialty)
Molecular cloning
Biochemical laboratory techniques
Doctor of Philosophy

Full Job Description

Trutino Biosciences is a research-driven biopharmaceutical company with a mission to restore immuno-balance in cancer patients by developing the next generation cytokine therapies that can safely activate tumor-fighting immune cells at the disease site without causing adverse side effects. Trutino’s proprietary On-Demand-Cytokine (ODC) platform technology enables the design of therapeutic candidates that can be systemically delivered in an inactive form and be locally activated directly at the tumor site, thereby avoiding the extreme toxicity of conventional cytokine therapies, and potentially improving efficacy either as a single agent or in combination with other treatment modalities.

We are seeking a highly motivated Research Scientist with strong protein production and engineering expertise, who can focus on driving innovative, new approaches in drug discovery. The successful applicant will have extensive background in recombinant protein expression and purification methods, protein characterization and protein engineering, and will be responsible for developing and manufacturing novel zytokine (inactive cytokines) and zymokine (inactive chemokines) therapeutic candidates based on Trutino’s On Demand Cytokine Platform technology.

This position requires deep technical knowledge, exceptional communication skills (both written and oral), and the ability to work on and move forward multiple projects simultaneously under minimal supervision. The successful candidate will be a strategic member in a fast-paced, collaborative research setting.

Duties

Contribute to the design and development of novel recombinant protein therapeutics.
Design/plan experiments, perform hands-on protein expression, purification, and analytical characterization of therapeutic candidates using standard techniques.
Perform small to mid-scale expression of recombinant proteins in transient eukaryotic expression systems (mammalian, insect)
Generate stable expression cell lines using cells such as HEK293 and CHO.
Protein Purification duties include: preparation and packing of chromatography columns, conducting low endotoxin chromatography, including operating analytical and preparative fast performance and high-pressure chromatography systems.
Analytical characterization duties include: running SDS-PAGE, endotoxin measurement, protein quantitation assays, FPLC, HPLC, Biacore, analytical SEC analysis.
Prepare and optimize formulation buffer for protein stability.
Optimize protein expression and modulate protein function through molecular engineering approaches and the design of protein variants.
Develop new protocols and troubleshoot existing protocols to optimize protein production/purification process.
Analyze, summarize, and present experimental results to internal and external scientists, share technical expertise with other colleagues, train and/or supervise other personnel, if needed.
Stay abreast of current industrial protein expression and purification technologies.
Publish findings in scientific journals and/or scientific meetings.

Qualifications

A PhD in Biochemistry, Biochemical Engineering, Chemical Engineering or related areas and post-doctoral experience of 3+ years is required.
A minimum of 2-3 years’ experience in recombinant protein engineering, expression and purification in either an academic, institutional or industrial setting.
Experience with transient expression of proteins in mammalian cell lines such as. Freestyle / Expi293 and CHO cells is required. Experience with other eukaryotic expression systems is a plus.
Experience with stable cell line generation for protein production is desirable.
Experience with affinity, IEX, hydrophobic and size-exclusion chromatography is required.
Extensive hands-on experience in the following areas is required: DNA manipulation and cloning, transformation/transfection, cell culture and analytical protein characterization.
Demonstrated productivity during graduate and/or post-doc training, with clear evidence of peer-reviewed publications in top tier journals.
Ability to organize and communicate complex data sets in a clear and concise manner.
Candidate should be hands-on with a pro-active attitude, a strong team player with excellent oral and written communication skills and with a demonstrated ability to move projects forward and plan next steps with minimal supervision.

Preferred Experience and Skills

Ability to actively contribute scientifically to immunotherapy drug discovery research programs, including identification and validation of novel targets.
Review scientific literature and stay abreast of discoveries in immunotherapy field.
Ability to represent research team and communicate goals/deliverables to senior management
Experience in mentoring and/or leading PhD level and non-PhD level scientists.
Industry experience highly preferred.

Trutino Biosciences is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Job Category: R&D

Job Type: Full Time

Job Location: United States - California - San Diego

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