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Research Assistant – Automated Organic Synthesis

Onepot -
South San Francisco, CA

Quick Apply

Job Details

Full-time
$70,000 - $100,000 a year

Qualifications

Academic institution experience
Programming languages

Full Job Description

Team: Laboratory Automation & Operations

Company snapshot

We are revolutionizing organic chemistry with a fully automated synthesis platform. We combine high-throughput robotics and analytical technologies to accelerate small-molecule discovery.

What you'll do

Automated Synthesis Execution: Set up and run organic synthesis reactions using robotic liquid-handling systems (e.g., Opentrons OT-2), including sensitive reactions under inert conditions (glovebox, Schlenk lines) and photochemical reactions.
Robotic Work-Up Automation: Implement automated protocols for quenching, extraction, filtration, and evaporation (e.g., plate-based evaporators).
Stock Solution Preparation: Accurately weigh, dissolve, standardize, label, and organize reagent stock solutions and plates for robotic workflows.
Reagent Receipt & Qualification: Receive incoming chemical reagents and lab consumables, perform quality inspections, document batch information, and maintain inventory accuracy.
General Lab Maintenance: Manage shipping and receiving, maintain laboratory glassware and equipment, and perform routine upkeep to ensure seamless lab operations.
Data Management: Accurately document reaction parameters, analytical data (LC-MS, GC-MS), and reagent metadata in electronic lab notebooks, ensuring data integrity for AI/ML model development.
Instrument Maintenance: Regularly calibrate and maintain laboratory robotics, analytical instruments, and related equipment; troubleshoot technical issues as needed.
Protocol & Software Development: Assist in writing and refining Python or Bash scripts for automating laboratory workflows, data parsing, plate mapping, and instrument control.
Safety Compliance: Ensure adherence to chemical safety protocols, maintain accurate chemical inventories, and follow laboratory SOPs.

Minimum qualifications

B.S. or M.S. in Chemistry, Chemical Engineering, or related field.
1+ year experience in an organic chemistry laboratory (industry or academia).
Familiarity with liquid-handling robots or analytical instrumentation.
Basic scripting proficiency (Python, Bash) or demonstrated ability to quickly acquire these skills.
Strong organizational skills with meticulous attention to detail.

Nice-to-have

Experience in high-throughput experimentation or automated reaction work-ups.
Knowledge of inert-atmosphere handling techniques (glovebox, Schlenk).
Experience with laboratory information management systems (LIMS) or similar data-management software.
Hands-on experience with spectroscopy and chromatography techniques.

What we offer

An exciting opportunity to contribute directly to groundbreaking automated chemical synthesis.
Close collaboration with company founders, synthetic chemists, and machine learning experts.
Competitive salary and comprehensive benefits.
A dynamic, innovative work environment where your contributions significantly advance scientific discovery.

Our company is an equal-opportunity employer.

Compensation Range: $70K - $100K

Quick Apply

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Research Assistant – Automated Organic Synthesis

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