Who we are…
Cell Signaling Technology (CST) is a different kind of life sciences company, one founded, owned, and run by active research scientists, with the highest standards of product and service quality, technological innovation, and scientific rigor for over 20 years. We consistently provide fellow scientists around the globe with best-in-class products and services to fuel their quests for discovery.
Helping researchers find new solutions is our main mission every day, but it's not our only mission. We're also dedicated to helping identify solutions to other problems facing our world. We believe that all businesses must be responsible and work in partnership with local communities, while seeking to minimize their environmental impact. That's why we joined 1% for the Planet as its first life science member, and have committed to achieving net-zero emissions by 2029.
The role...
We are seeking an experienced and passionate scientist to collaborate closely with our dynamic team in developing groundbreaking technologies and validating innovative products. In this role, you will drive the research for integrating CST's antibodies with new and cutting-edge technologies. Specifically, your expertise will be instrumental in propelling the development of new products using orthogonal assays. This requires critical thinking about experimental design, data analysis, and future directions. This is an exceptional opportunity for a dedicated scientist to flourish within a supportive and collaborative team. This is an onsite role.
You'll have the opportunity to...
Essential duties and responsibilities (with estimated percentage allocation)
50% Assay Development and Optimization
- Design, develop, and optimize current proximity assays using DNA-conjugated antibodies to achieve high sensitivity protein readout.
- Design, perform, and optimize experiments including Western blotting, PCR/qPCR, Flow Cytometry, Next-Generation Sequencing (NGS), and cell culture-based experiments to support the team initiatives.
- Validate newly developed assays by analyzing experimental results, troubleshooting issues, and refining protocols to ensure robust and reproducible data.
- Implement rigorous quality control for all experimental steps, including reagent selection and workflow standardization.
25% Data Analysis & Interpretation
- Analyze experimental data using appropriate statistical and bioinformatics methods to extract meaningful conclusions.
- Maintain accurate, detailed laboratory records and experimental documentation in compliance with company standards.
- Present data and findings in team meetings, providing scientific rationale for next steps.
10% Collaboration & Scientific Communication
- Collaborate closely with cross-functional teams to design and execute experiments aligned with project goals.
- Share scientific insights and progress updates with internal stakeholders to drive decision-making and project advancement.
- Contribute to the preparation of internal reports and presentations of research findings.
10% Technology Evaluation & Continuous Learning
- Stay current with advancements in single-cell analysis, DNA-conjugated antibody applications, and cellular signaling research.
- Identify opportunities for integrating new techniques or technologies to enhance assay capabilities and project outcomes.
5% Laboratory Operations & Compliance
- Maintain laboratory equipment, follow safety protocols, and ensure compliance with regulatory and company standards.
- Support day-to-day lab operations, including reagent preparation and inventory management.
Who you are and what you bring to the team...
- Ph.D. degree in biological sciences with bench lab experience.
- Experience in proximity extension assays.
- Extensive experience in PCR. This includes nested & two-step PCR, melt curve analysis, experience with hairpins /self-dimers /cross-dimers in primer designs, mastery PCR troubleshooting, experience with PCR additives, experience with gradient PCR, melting temperature (Tm) balancing, multiplex PCR.
- Experience in qPCR experiments. This includes the use of different intercalating dyes, designing and the use of TaqMan probes, multi-gene normalization, experience minimizing primer dimers at high cycles.
- Experience in antibody pair assays.
- Experience in Western Blot applications.
- Experience in immunoprecipitation assays.
- Experience in Tissue Culture including cell line maintenance, treatments, and lysis etc.
- Independently test hypotheses, plan experiments, troubleshoot, scientifically draw conclusions and propose future experimental ideas.
- Strong communication skills (both oral and written).
Ideally, you have...
- Ph.D. in a biological science (e.g. Biochemistry, Molecular Biology, Immunology, Cell Biology, Cancer Biology) with a minimum of 2 years of post-doctoral hands-on relevant bench lab experience.
- Experience in designing oligo structures.
- Experience with NGS techniques and library preps.
- Experience with Single Cell Technologies.
- Experience performing Flow Cytometry experiments.
- Computer proficiency including working knowledge of MS Office Suite, Google Docs, as well as a basic level of understanding of coding with R, Python or related applications.
Physical Conditions/Physical Requirements...
- Work in a laboratory setting (BSL1, BSL2, or BSL2+) with potential exposure to hazardous chemicals, biological materials, and controlled environments.
- Consistent wearing of assigned PPE (lab coats, gloves, safety glasses) and strict adherence to all lab safety protocols for hazardous or infectious materials.
- Ability to sit and/or stand for extended periods while conducting lab work, analyzing data, or supervising team activities.
- Frequent tasks requiring repetitive hand motions and fine motor skills, including pipetting, tube manipulation, slide and sample preparation, and operation of specialized laboratory equipment.
- Lifting, carrying, pushing, or pulling laboratory supplies or equipment up to 25 pounds (may be necessary).
- Mechanical aids or team lifting are used for heavier loads.
- Adaptability to varying laboratory noise levels from equipment such as centrifuges, freezers, and analytical instruments.
- Work area can be filled with collaborative discussion.
This position has a starting base salary range of $134,117 – $160,126 per year, which the company, in good faith, reasonably expects to pay for this role at the time of posting. Actual compensation within this range will be determined based on factors including, but not limited to, relevant skills, qualifications, experience, and internal equity.
What we offer...
At Cell Signaling Technology (CST), we recognize that people will always be our most important asset. Providing a safe, inclusive, and stimulating working environment that understands the importance of diversity, human dignity, and meaningful work is as important as establishing company policies that incorporate excellent health insurance and pay benefits. We recognize that the development of people is the key to their happiness and thus ensure every employee has impactful discussions with their manager and develops actionable performance and professional development plans. Lastly, we are committed to engaging and supporting our employees in committees and philanthropy that benefit their local communities and environment through community investment programs.
Benefits
- Medical (BCBS) and Dental (Delta Dental) plans paid at 90%
- Vision Insurance
- Life Insurance, Short and Long Term Disability
- Flexible Spending accounts
- 401(k) Plan with 6% match
- Tuition Reimbursement
- Generous PTO package
- Parental Leave
- Pet Insurance
- Employee Assistance Program
- Onsite Subsidized Cafeteria
- Free Parking
Cell Signaling Technology (CST) is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
AGENCIES
All resumes submitted by search firms/employment agencies to any employee at Cell Signaling Technology (CST) via email, the Internet, or in any form and/or method will be deemed the sole property of CST unless CST engaged such search firms/employment agencies for this position and a valid agreement with CST is in place. In the event a candidate who was submitted outside of the CST agency engagement process is hired, no fee or payment of any kind will be paid.
