Top 1195 Systems engineer sf Jobs

Senior Computer Systems Validation Engineer
Vaxcyte —San Carlos, CA
- $164,000 - $190,000 a year
- Hybrid work
- 7 years
- Azure
- Computer Science
Senior Data Engineer [Remote-US]
Quanata —Remote
- $215,000 - $300,000 a year
- Online Application
- Remote
- 6 years
- SQL
- Analysis skills
- Paid parental leave
- Health insurance
Quick Apply
Senior II Fullstack Software Engineer, GRC
Vanta —Remote
- $224,000 - $263,000 a year
- Full-time
- Remote
- 8 years
- Mentoring
- Senior level
- Commuter assistance
- Paid parental leave
Senior Software Engineer, Developer Experience
Vanta —Remote
- $224,000 - $263,000 a year
- Full-time
- Remote
- Senior level
- Paid parental leave
- Paid holidays
Software Engineer
Goliath Partners —San Francisco, CA
- $300,000 - $500,000 a year
- Computer Science
- Bachelor of Science
- Office
Salesforce Platform Engineer
Vanta —Remote
- $128,000 - $151,000 a year
- Full-time
- Remote
- 5 years
- Senior level
- Communication skills
- Commuter assistance
- Paid parental leave
Machine Learning Eval Engineer
Reducto —San Francisco, CA
- $150,000 - $300,000 a year
- Full-time
- Mid-level
- Office
- Dental insurance
- Parental leave
Support Engineer (SF)
Plain —San Francisco, CA
- $150,000 - $180,000 a year
- Full-time
- Hybrid work
- Mid-level
- Office
- SQL
Research Engineer / Scientist, Post-Training
Letta —San Francisco, CA
- Full-time
- Mid-level
- Office
Senior Fullstack Software Engineer, GRC
Vanta —Remote
- $195,000 - $229,000 a year
- Full-time
- Remote
- 5 years
- Mentoring
- Senior level
- Commuter assistance
- Paid parental leave
Sr. Performance Engineer
Dyzaro Performance —San Francisco, CA
- Full-time
- Merchandising
- Scripting
- Senior level
Staff Engineer, Product Engineering
Vanta —Remote
- $260,000 - $306,000 a year
- Full-time
- Remote
- System design
- Mentoring
- Senior level
- Commuter assistance
- Paid parental leave
ML Engineer, Discovery Applications
Mithrl —San Francisco, CA
- $150,000 - $200,000 a year
- Full-time
- Office
- Analysis skills
- Senior level
- Health insurance
- Dental insurance
Finance & Accounting Manager
Convergent Research —Remote
- $111,000 - $159,000 a year
- Full-time
- Remote
- English
- GAAP
- Travel
- AD&D insurance
- Disability insurance
Research Engineer / Scientist, Self-Improvement
Letta —San Francisco, CA
- Full-time
- Mid-level
- Office
Equipment Engineer (Smart Factory)
LG Energy Solution Michigan, Inc. —Holland, MI
- Full-time
- Engineering
- Experience equivalent to degree accepted
- Entry level
Quick Apply
Engineer II, Conjugation Development and Manufacturing
Vaxcyte —San Carlos, CA
- $146,000 - $171,000 a year
- Bachelor of Science
- Mid-level
- Bachelor's degree
Senior AI GRC Engineer
Vanta —Remote
- $227,000 - $267,000 a year
- Full-time
- Remote
- AWS
- APIs
- Senior level
- Commuter assistance
- Paid parental leave
Senior Back End Engineer [Remote-US]
Quanata —San Francisco, CA
- $195,000 - $280,000 a year
- Online Application
- Remote
- 5 years
- AWS
- Bachelor's degree
- Paid parental leave
- Health insurance
Quick Apply
Senior Fullstack Engineer, Emerging Products
Vanta —Remote
- $195,000 - $229,000 a year
- Full-time
- Remote
- 5 years
- Mentoring
- Senior level
- Commuter assistance
- Paid parental leave

I want to receive the latest job alert for systems engineer sf

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Senior Computer Systems Validation Engineer

Vaxcyte -
San Carlos, CA

Apply Now

Job Details

$164,000 - $190,000 a year

Qualifications

Data integrity assurance
Software engineering
GAMP
Content creation for technical audiences
SQL databases
Relational databases
Technical documentation
Pharmaceutical regulatory compliance
Database testing
FDA 21 CFR Part 11
Public Cloud
Data integrity and documentation
Pharmaceutical company experience
Software development experience
Data validation
Technical writing experience within technology
Project stakeholder communication
Pharmaceutical manufacturing facility experience

Full Job Description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

The Senior Computer Systems Validation (CSV) Engineer is responsible for leading validation activities for cloud based GxP systems to ensure they meet regulatory, quality, and operational requirements throughout the system lifecycle. The role focuses on traditional Computer System Validation with application of risk-based Computer Software Assurance (CSA) principles where appropriate.

The individual will work closely with IT and Quality teams to validate and maintain GxP systems across their lifecycle. Strong experience validating relational databases, cloud infrastructure, and integrated applications in regulated biotech or pharmaceutical environments is required.

This is a hands-on role requiring authoring and executing validation documents and protocols for GAMP 5 systems.

This is a hybrid role with minimum of 3 days a week onsite at San Carlos, CA location.

Essential Functions:

Hands-on lead full lifecycle Computer System Validation activities for cloud based GxP systems including databases, and applications.
Author, update, execute and maintain validation deliverables such as Validation Plans, User Requirements, Functional Specifications, Risk Assessments, Traceability Matrices, IQ, OQ, PQ protocols, and Summary Reports.
Perform risk assessments to define validation scope, testing strategy, and documentation requirements in alignment with CSA principles.
Define and execute validation strategies for data platforms and system components, ensuring systems meet defined functional, security, and data integrity requirements
Assess and validate end to end data flows between upstream source systems and downstream applications to ensure accuracy, completeness, and traceability.
Evaluate system changes for validation impact and ensure validated systems remain compliant through appropriate testing and documentation.
Ensure validation activities align with automated build and deployment pipelines, confirming that system releases maintain validated state and appropriate validation evidence is generated.
Support change control, deviation management, periodic review, and lifecycle management of validated systems.
Participate in internal audits and regulatory inspections, providing validation documentation and rationale as required.
Contribute to continuous improvement of validation procedures aligned with evolving CSA guidance and cloud delivery models.

Requirements:

Bachelor’s degree in Computer Science, Engineering, Life Sciences, or related field, or equivalent professional experience.
Minimum 7 years of experience in Computer System Validation within biotech manufacturing and lab data systems. Other combinations of education and/or experience may be considered.
Must have technical knowledge of IT infrastructure, software engineering, programming, databases and data integrations.
Experience working in modern system environments utilizing CI/CD pipelines or automated release processes.
Strong hands-on experience validating GAMP 5 systems for biotech manufacturing.
Deep understanding of FDA 21 CFR Part 11, Part 210, Part 211, Annex 11, data integrity requirements, and risk-based validation methodologies.
Strong technical writing skills and ability to create comprehensive validation documentation.
Ability to communicate validation risks and requirements clearly to IT and Quality stakeholders.

Other combinations of education and/or experience may be considered.

Preferred Qualifications:

Hands-on experience validating cloud based GxP systems, specifically Azure.
Familiarity with infrastructure as code frameworks like GitHub, Terraform etc.
Experience applying CSA principles to custom data applications in GxP cloud.
Microsoft Azure or similar technical certifications.

Reports to: Senior Manager, Data Systems

Location: San Carlos, CA

Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy):

Hybrid (minimum of 3 days per week onsite)

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $164,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary.

Relocation:

This role is not eligible for relocation assistance.

#LI-JN1

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

Apply Now

Refine Your Search

systems engineer sf jobs

Senior Computer Systems Validation Engineer

Senior Data Engineer [Remote-US]

Senior II Fullstack Software Engineer, GRC

Senior Software Engineer, Developer Experience

Software Engineer

Salesforce Platform Engineer

Machine Learning Eval Engineer

Support Engineer (SF)

Research Engineer / Scientist, Post-Training

Senior Fullstack Software Engineer, GRC

Sr. Performance Engineer

Staff Engineer, Product Engineering

ML Engineer, Discovery Applications

Finance & Accounting Manager

Research Engineer / Scientist, Self-Improvement

Equipment Engineer (Smart Factory)

Engineer II, Conjugation Development and Manufacturing

Senior AI GRC Engineer

Senior Back End Engineer [Remote-US]

Senior Fullstack Engineer, Emerging Products

I want to receive the latest job alert for systems engineer sf

Related Searches

Explore jobs in more locations

Join our Mission to Protect Humankind!

Summary:

Essential Functions:

Requirements:

Job Seeker Tools

Employer Tools

Browse

Stay Connected