Scientist

Integrated Resources, Inc - Spring House, PA (30+ days ago)4.6


Job Summary

Title: Scientist

Duration: 12 months+

Location: Spring House, PA

Description:

The position offers an exciting opportunity to engage in the discovery and molecular engineering of Biotherapeutics for unmet medical needs. You will be an integral member of the Antibody V gene cloning group

Responsibilities and Duties

Molecular biology tasks such as PCR-based cloning, construct design, RNA purification, RT-PCR, expression vector engineering etc.

High Throughput V gene recovery from Hybridomas or single B cell (SBC) platform

Computational expertise in DNA sequence analysis and in silico cloning

Independently presents/defends scientific findings in cross-functional project teams/initiatives, drafts protocols, SOPs, technical reports etc.

Qualifications and Skills

  • M.S in molecular biology, biochemistry, biophysics, immunology or a related discipline with 1-3 years of experience OR a BS degree in molecular biology, biochemistry, immunology, or related discipline with 2-4 years of experience is required (preferably in industry setting)
  • Demonstrated knowledge of the current Molecular Biology techniques in the realm of Antibody/Protein Engineering,
  • Hands-on experience with high-throughput construct design, restriction-free and restriction-based cloning is required
  • Clinical/Preclinical discovery of antibody based biotherapeutics in an industrial setting is preferred
  • Hands on experience with bispecific and/or CAR-T scaffold design, engineering and profiling is preferred
  • Hands-on experience in HTP-based binding assays (such as ELISA, SPR, MSD) and/or cell-based (Intellicyt/iQue) for screening antibody variants is preferred
  • Hands on experience in Phage or Yeast Display technology for discovery and/or optimization is preferred

Job Type: Contract