Integrated Resources, Inc - Spring House, PA4.3

30+ days agoContract

Job Summary

Title: Scientist

Duration: 12 months+

Location: Spring House, PA


The position offers an exciting opportunity to engage in the discovery and molecular engineering of Biotherapeutics for unmet medical needs. You will be an integral member of the Antibody V gene cloning group

Responsibilities and Duties

Molecular biology tasks such as PCR-based cloning, construct design, RNA purification, RT-PCR, expression vector engineering etc.

High Throughput V gene recovery from Hybridomas or single B cell (SBC) platform

Computational expertise in DNA sequence analysis and in silico cloning

Independently presents/defends scientific findings in cross-functional project teams/initiatives, drafts protocols, SOPs, technical reports etc.

Qualifications and Skills

  • M.S in molecular biology, biochemistry, biophysics, immunology or a related discipline with 1-3 years of experience OR a BS degree in molecular biology, biochemistry, immunology, or related discipline with 2-4 years of experience is required (preferably in industry setting)
  • Demonstrated knowledge of the current Molecular Biology techniques in the realm of Antibody/Protein Engineering,
  • Hands-on experience with high-throughput construct design, restriction-free and restriction-based cloning is required
  • Clinical/Preclinical discovery of antibody based biotherapeutics in an industrial setting is preferred
  • Hands on experience with bispecific and/or CAR-T scaffold design, engineering and profiling is preferred
  • Hands-on experience in HTP-based binding assays (such as ELISA, SPR, MSD) and/or cell-based (Intellicyt/iQue) for screening antibody variants is preferred
  • Hands on experience in Phage or Yeast Display technology for discovery and/or optimization is preferred

Job Type: Contract