U.S. Environmental Protection Agency (EPA)
How to Apply
A complete application consists of:
Transcript(s) – For this opportunity, an unofficial transcript or copy of the student academic records printed by the applicant or by academic advisors from internal institution systems may be submitted. All transcripts must be in English or include an official English translation. Click here for detailed information about acceptable transcripts.
A current resume/CV, including academic history, employment history, relevant experiences, and publication list
Two educational or professional recommendations
All documents must be in English or include an official English translation.
If you have questions, send an email to EPArpp@orau.org. Please include the reference code for this opportunity in your email.
4/6/2020 3:00:00 PM Eastern Time Zone
- Applications will be reviewed on a rolling-basis.
A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Biomolecular and Computational Toxicology Division (BCTD) in Research Triangle Park, North Carolina. EPA ORD recently reorganized and these are the newly named Centers/Divisions/Branches. This was formerly in ORD's National Health and Environmental Effects Research Laboratory (NHEERL), Integrated Systems Toxicology Division (ISTD).
This research project aims to improve the characterization of thyroid hormone metabolism and transport in the presence of environmental chemicals. Results from this study will provide data for complex systems biology models used to support human risk assessment. This research project will also develop in vitro methods to help describe cyanotoxin exposure and subsequent human health effects. Results from this study will provide guidance for drinking water treatment and health advisories. Overall, the project will utilize in vitro assays, which include the use of human hepatocytes, colonocytes, kidney cells, neurons, and astrocytes.
Under the guidance of a mentor, the participant may be involved in the following research activities:
Conducting literature searches to learn about current research regarding thyroid hormone metabolism and the cytotoxic effects of cyanotoxins
Designing and conducting experiments, plating and maintaining cells, and analyzing samples using LC/MS, RT-PCR, and other in vitro assays
Designing and implementing experiments to assess thyroid hormone metabolism and cyanotoxin toxicity in a variety of cellular matrices, including two- and three-dimensional cell culture models
Conducting time dependent and dose response experiments, preparing standard solutions and cells for experimentation, analyzing samples, and analyzing data using statistical software
Interacting with an interdisciplinary research team with expertise in toxicology, developmental biology, neurobiology, embryology, analytical chemistry, and biochemistry
Attending conferences and presenting research findings at scientific meetings
Anticipated Appointment Start Date:
This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. The initial appointment is for one year, but may be renewed upon recommendation of EPA and is contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at EPA in the Research Triangle Park, North Carolina, area. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits.
Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA. OPM can complete a background investigation only for individuals, including non-US citizens, who have resided in the US for the past three years.
The qualified candidate should have received a master's degree in one of the relevant fields, or be currently pursuing the degree and will reach completion by June 5, 2020. Degree must have been received within five years of the appointment start date.
Tissue culture techniques
Human cell culture
In vitro assays
Master's Degree received within the last 60 months or anticipated to be received by 6/5/2020 11:59:00 PM.
Earth and Geosciences (1 )
Engineering (1 )
Environmental and Marine Sciences (1 )
Life Health and Medical Sciences (7 )
I certify that I have lived in the United States for the past three years.