The Medicine Team Lead for Sickle Cell Disease (MTL) is responsible for leading the cross-functional medicine teams for all medicines from Proof of Concept to First Major Approval, and co-lead the team following first major filing through to end of lifecycle to deliver additional Life Cycle Management (LCM) development activities. Currently, this includes the complete program for Rivipansel, including lifecycle indications, as well as all GPD activities for 3 pre-POC assets medicines, and active business development opportunities.
The MTL will strive to maximize the long-term value of the medicine through development of integrated strategies and aligned execution plans which cover all aspects of drug development – Commercial Development, Clinical, Medical, Regulatory, Market Access, and Operations.
The MTL Franchise responsibilities will also include leading above medicine strategic decision making for the franchise including product concept development and maintenance, transition planning for advancing medicines and leadership of technical due diligence for Business Development opportunities. The MTL can represent the CDO for Sickle Cell Therapeutic Area activities,
The MTL will have direct reports including, Global Clinical Leads and/or administrative partners.
MTL Role Highlights
- Leads the cross-functional MEDICINE TEAM responsible for maximizing the long-term value of the medicine.
- Integrates MEDICINE TEAM’s deliverables and serves as the single point of accountability for the medicine within GPD.
- Drives creation of the Integrated Medicine Plan (IMP) setting global strategies and aligned operational plans which are built based on customer insights globally to maximize the value of our medicines to customers.
- Creates an inclusive environment to ensure input from all team members, regions, lines, and management are heard, validated and considered throughout the lifecycle.
- Manages interactions with internal stakeholders and governance bodies on behalf of the MEDICINE TEAM; ensures transparent information flow internally and externally.
- Continuously drives quality, cost and speed improvements, and makes necessary tradeoff decisions to maximize medicine value.
- Proactively manages medicine-related events, risks and opportunities.
- Franchise responsibilities will also include leading above medicine strategic decision making for the franchise including product concept development and maintenance, transition planning for advancing medicines and leadership of technical due diligence for Business Development opportunities
Strategy and Execution for Each Program within Remit
- Drive the creation of an IMP setting global strategies and aligned operational plans which are built based on customer insights globally to maximize the value of our medicines to customers.
- Act as the single point of accountability for the medicine/medicine within GPD. Is the point of contact and program representative to executive leadership, governance and other decision-making bodies.
Hold and manage the overall medicine/medicine budget within GPD; make investment decisions and trade-offs across the program.
Drive execution of strategies and programs to maximize medicine/medicine performance including:
Program Delivery – Accountable for delivering program milestones in a timely, cost-effective and high quality fashion (including de-risking medicines and investments as early as practical).
Risk Management – Pro-actively and continuously identify and communicate program risks; develop and implement risk mitigation strategies and resolve critical program issues.
Resource Management – Work with leaders across functions to ensure that projects have appropriate resources and technical expertise to meet strategic objectives.
Program Management – Accountable for ensuring that the program is managed appropriately within budget and that resource forecasts for all activities across all functions are accurate and up to date
Accountable for driving technical review for the program and driving overall due diligence related to the program
Maintain scientific and regulatory awareness to ensure that project plans reflect the latest scientific/medical developments and regulatory/commercial environment.
Create, lead and deliver continuous improvement strategies to improve productivity and increase medicine value.
Ensure the articulation of appropriate standards and specifications for input to contracts with vendors, suppliers and industry partners to deliver the project.
Team Leadership and Stakeholder Management
• Drive effective operation of the MEDICINE TEAM to ensure flawless execution of programs and activities across functions and regions.
• Create and/or lead a motivated, committed and engaged MEDICINE TEAM. Model and expect effective team behavior to achieve the program goals.
• Accountable for decision-making (strategic, operational, and budgetary) within the MEDICINE TEAM for the medicine/medicine. Effectively leverage the expertise of MEDICINE TEAM members in challenging the status quo, providing decision-making recommendations and effectively resolving conflict.
• Develop an effective and collaborative work environment across the Business Units, GPD and partner lines. Ensure that inputs from all MEDICINE TEAM members, regions, lines and management are heard, validated and considered throughout the program lifecycle.
• Manage internal relationships (e.g., platform lines, other Bus) and external relationships (e.g., customers, regulatory agencies, key opinion leaders) either directly or through appropriate medicine team members. Serve as medicine champion by negotiating with and influencing key internal/external stakeholders.
• Engage executive leadership regarding strategic issues, project plans, options and recommendations to support uninterrupted program execution.
Franchise Strategic Management
• Lead development strategy for Franchise area including product concept development and maintenance
Lead transition team for advancing medicines through collaboration with project leaders and managers in Research & Development and/or with licensing partners ensuring a seamless transition of potential medicines through development, registration and/or commercialization.
Work in concert with appropriate medicine team members to build a network to key opinion leaders to support program development and commercialization.
Lead technical due diligence for Business development opportunities within franchise area
The MTL can represent the CDO for Sickle Cell Therapeutic area activities
The MTL can act as the GPD external contact for critical external activities, patient advocacy and Key Opinion Leader interactions
Must have a PhD, PharmD or equivalent
Minimum of 10 years drug development experience and expertise. Must have in-depth knowledge of drug development and commercialization processes.
• Track record of high performance in a relevant discipline within pharmaceutical development and/or commercialization.
• Experience leading development, medical or commercial teams.
• Experience managing the drivers of commercial value in a medicines development, medical or commercial role.
• Experience with the process of developing a competitively superior product label.
• Knowledge of regulatory review and response processes.
• Proven management and leadership skills.
• Demonstrated initiative, creativity, strategic capabilities, and strong analytical and financial management skills.
• Ability to lead by example and effectively implement strategies through influence and persuasion of executive leadership and internal/external stakeholders.
• Ability to lead effectively in a cross-functional, matrix team environment. Ability to manage team dynamics and to recognize when team interventions are required to enhance team effectiveness to ensure delivery of program deliverables.
• Ability to work on multiple tasks and prioritize effectively in order to successfully deliver activities against all revenue, cost, time and quality requirements.
• Ability to lead and implement continuous improvement strategies.
• Possesses enthusiasm, energy, confidence and outstanding communication skills.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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