Research Associate 2, Pre-Formulation & Protein Characterization

BioMarin - Novato, CA4.0

Full-time
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BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.

Summary
The candidate will be a highly motivated individual ready to work in Process Sciences as part of a collaborative, multidisciplinary drug product development environment. The position will focus on support for biochemical and biophysical characterization of proteins and their degradation products. This position will help in understanding all aspects of the protein’s structure and functionality, including solubility profiles, protein thermodynamics/kinetics and interactions with other molecules.

Responsibilities
The Research Associate position will be part of the Preformulation and Protein Characterization group within Process Sciences. The scope of the work includes preformulation and drug product development in support of early candidate and process selection. The individual will be responsible for supporting novel biophysical and biochemical methodologies for protein characterization. The ideal candidate may have experience in biologic formulation and characterization using a myriad of analytical tools for spectroscopic, calorimetric and physicochemical solution analysis. The candidate should be an effective communicator of ideas, project goals and results to team members across cross-functional departments.

Responsibilities include the following:
Support pre-formulation and characterization activities within Process Sciences
Produce, analyze, document and report results, achieving reproducible, high quality data in a timely manner.
Keep accurate and detailed laboratory records.
Communicate daily results and summarize progress with supervisor by oral update and/or written report.
Be a hands-on presence in the laboratory
Ability to set up, maintain and provide training of equipment and instrumentation to support projects.
Prepare and write technical reports, summarizing the results of studies.
Participate in multi-departmental projects and discussions, communicating data, results and recommended next steps to project and group leaders clearly and effectively
Interact with various functional groups in Process Development, Formulation Development, Analytical Development, QC, and Manufacturing
Work on multiple projects simultaneously while meeting aggressive timelines

Education
Bachelors degree in scientific discipline

Experience
2+ years of relevant academic or industry experience in protein biochemistry.

Experience with general molecular biology and biochemistry.
Hands-on experience in the biotechnology industry or academic setting with a broad range of techniques focused on protein characterization is a plus
Spectroscopic methods (UV, CD, NMR, fluorescence, FTIR and Raman)
Thermodynamic methods (DSC and ITC)
Light scattering methods (DLS and SLS)
Subvisible particulate characterization methods (MFI and HIAC)
Separation methods (AUC)
Experience with multiple HPLC methodologies, hardware and software platforms is desired
Strong analytical troubleshooting skills are required
Strong verbal/written communication and interpersonal skills are required

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.