2020 Quantitative Pharmacology & Pharmacometrics Intern

Merck - West Point, PA4.1

Full-time | InternshipEstimated: $68,000 - $86,000 a year
Job Description

The Future Talent Program features internships that last up to 12 weeks and will include one or more projects. These opportunities in our Research Labs can provide you with great development and a chance to see if we are the right company for your long-term goals.

Our company's Research Lab’s Quantitative Pharmacology & Pharmacometrics (QP2) group within the Pharmacokinetics, Pharmacodynamics and Drug Metabolism department in Rahway, NJ, and West Point, PA, is seeking summer interns. The Quantitative Pharmacology and Pharmacometrics (QP2) group at our company provides pharmacokinetic/pharmacodynamic analysis and modeling and simulation support to enable decisions and accelerate research lab programs across the pipeline in Discovery and Preclinical Sciences, Early Development, and Late Stage development, including product value enhancement. The intern will work closely with a QP2 staff as mentor to develop and apply quantitative mathematical, physiologic, pharmacologic or statistical models and simulations to support ongoing projects and/or to contribute to the development and implementation of new capabilities, standards, and approaches. Students should have strong written and oral communication skills and Intern students will have an opportunity to present their research results in both oral and written forms.

Specific intern projects will be developed with the mentor consistent with completion in the timeframe of the internship such as

Gaining deep knowledge of cutting-edge Bayesian modeling techniques in pharmacometrics to improve knowledge of novel pharmacometrics approaches, and the work will also spur new developments in multiscale, quantitative systems pharmacology, and joint population PK/PD modeling across therapeutic areas
Develop a generic platform modeling tool that streamline the implementation of Pharmacometrics IRT for neurodegenerative disease
Utilize QSAR-based machine learning methods and an existing brain PBPK model to better characterize the PK of small molecule drugs in rodent CNS models.
Develop a model linking release rates with drug physicochemical parameters and depot characteristics such as size and shape quantified non-invasively by MR imaging.
Use mechanistic modeling to predict clinical outcomes as well as interpret and build mechanistic models from various types of biological data, fit and qualify data-driven mechanistic models and frame and answer scientific questions in supporting clinical decisions.
Understand different modeling approaches, including PBPK, minimal PBPK, and population PK to help develop and validate models using preclinical experimental data

We are seeking intern candidates at all levels with strong academic performance, communication skills, teamwork, and the ability to work in a multi- functional environment.

Education Requirement:
Required: Candidates must be a currently enrolled undergraduate sophomore, junior, or senior student pursuing a bachelor’s degree OR enrolled in a PhD or MS degree program in Pharmacometrics, Clinical Pharmacology, Clinical PK/PD, Mathematics, Pharmaceutical Sciences, Statistics, Bioengineering, Chemical Engineering, Computer Science or related areas.

Required Experience and Skills:
Candidates must be available to work full-time for up to (12) consecutive weeks beginning in May or June of 2020.
Candidates must have completed at least (2) years of studies toward bachelor’s degree by June 2020.

Preferred Experience:
Strong computational skills and interest in programming in languages such as NONMEM, MATLAB, Monolix, R or other related languages
Experience in data visualization approaches and building apps (e.g. RShiny app development)
Familiarity with population modeling principles, differential equations and Bayesian statistics
Knowledge or interest around machine learning, cheminformatics, pharmacodynamics/pharmacokinetics and pharmacokinetic modeling
Imaging processing knowledge is a plus
GPA of 3.0 or higher is preferred.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





If you need an accommodation for the application process please email us at staffingaadar@merck.com