Principal Scientist, BioMedicine Design, Protein Engineering

Pfizer Inc. - San Francisco, CA4.2

Full-timeEstimated: $130,000 - $180,000 a year

BioMedicine Design’s Antibody Engineering Group, based at Pfizer’s Center for Therapeutic Innovation (CTI) San Francisco, is seeking a Principal Scientist to discover and engineer therapeutic proteins. The candidate will be an essential member of the Biomedicine Design - The Centers for Therapeutic Innovation (CTI) - California Protein Engineering Group and will have a demonstrated record of leading drug discovery programs. He/she will use molecular biology expertise, phage/yeast display, protein expression, purification and biological characterization in the development of protein therapeutics .


The candidate will be responsible for all aspects of protein therapeutic discovery and optimization including antibody selection, screening, characterization, removal of liabilities, humanization and affinity maturation.


A PhD Degree in Molecular Biology, Biochemistry, or related life science discipline
5+ years post PhD experience in laboratory research, preferably in an industry setting
Strong molecular biology skills including DNA subcloning, cDNA library building, DNA mutagenesis design and PCR techniques
Experience in assay development, including protein-protein binding assays, ELISA and Western blot
Working experience with phage and/or yeast antibody display libraries is required
Experience designing panning and screening strategies that will enable the selection of desirable antibodies/peptides against targets
Excellent written and oral communication skills
It is essential for the individual to work with other group members as a team
Strong publication record

Next Generation Sequencing experience is a plus
Experience in protein expression, purification and characterization is a plus.

Ability to perform mathematical calculations and ability to perform complex data analysis
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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Other Job Details:
Eligible for Relocation Package: yes
Eligible for Employee Referral Bonus: yes
N (Other) (United States of America)
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.