Full Job Description
This role leads efforts in assay development and screening of small molecules. The position is predominantly lab-based and supports projects from Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine. This scientist is responsible for identification of relevant assays for each project, development and optimization of these assays, and screening small molecules and may be responsible for leading several programs and overseeing several direct reports.
Collaborates with members of Principal Investigator labs at Tri-I academic institutions to adopt, refine and miniaturize existing functional assays.
Identifies and develops required assays for programs: procures reagents and consumables required for assays.
Optimizes assays for screening of small molecules.
Provides technical training to personnel in Principle Investigator labs on assay development and screening methodologies.
Submits progress reports and presents project updates at meetings.
Oversees several lab personnel.
Keeps current with literature and emerging trends.
Facilitates outsourcing of assays, as required.
PhD degree in pharmacology, molecular/cell biology, biochemistry, or related field.
Postdoctoral experience required.
Background in chemistry, biochemistry and biology/pharmacology desirable.
Experience with in vivo models beneficial.
A minimum of 3 years of experience working in small molecule drug discovery.
Demonstrated publication track record.
Expertise in project planning and management.
Knowledge, Skills and Abilities
In-depth knowledge of assay development and optimization methodology, and screening of small molecules.
Proficiency in cell culture, molecular biology, SDS-PAGE and western blotting.
Proficiency with biochemical assays including enzyme assays, in vitro ubiquitination, FRET, luminescence and fluorescence-based readouts.
Proficiency with cell-based assays including proliferation, toxicity, combination/synergy and target-engagement studies.
Proficiency in protein expression and purification.
Aptitude for quickly understanding the underlying biology required to design appropriate mechanistic or functional screening assays for each project.
Critical independent thinking, prioritization of tasks, strong problem-solving, and excellent communication skills.
Timely delivery of team goals and the ability to build productive relationships with colleagues, collaboration partners, and stakeholders.
Ability to coordinate and execute experiments for multiple programs concurrently.
Licenses and Certifications
Working Conditions/Physical Demands
Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Lower Manhattan Hospital, and NewYork-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity Employer. Weill Cornell Medicine provides equal employment opportunities to all qualified applicants without regard to race, sex, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, or genetic information.