Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist I, Toxicology in our Cambridge office.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Futureto people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
As a Scientist I, Toxicology , you will be empowered to develop and deliver novel in vitro assays and collaborate with other members of early toxicology. A typical day will include:
OBJECTIVE: Help us make safer drugs | The next generation of life changing medicines include gene therapies, oligonucleotides and cell therapies all honed to treat previously untreatable diseases. Help us shape this next generation of life-saving medicines by improving the therapeutics selected for further development based on proactive detection & de-risking of dose limiting toxicities. Deliver decision-making data | Design & deliver of state of the art in vitro assays to detect & de-risk organ-specific toxicities for medicines in discovery & development. Help shape the evolution of medicines related to a variety of therapeutic areas such as GI, neuroscience, oncology, and rare diseases for small molecules, biologics, and new modalities.
Develop and deliver novel in vitro assays, including biochemical, traditional and advanced cell culture such as organ-on-a-chip technologies and 3D organoids/spheroids.
Use molecular & cellular biology techniques to investigate mechanisms of drug-induced injury for small molecules, biologics, and new modalities across a broad range of therapeutic areas
Steer drug discovery teams to make safer medicines by using experience, in-house, and literature data.
Collaborate with other members of early toxicology, chemical toxicology, DMPK, and computational group to build hypothesis and quickly test them.
Work with CROs to generate data, compound screening, and data QC to assist with our “safety by design” vision.
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
PhD in toxicology, pharmacology, biology, biomedical sciences or related discipline with at least 2-4 years of post-PhD experience in academia or pharmaceutical industry. Candidates with a Masters in the above disciplines with 6+ years of relevant experience in pharmaceutical industry or other scientific organizations will also be considered.
Experience with mammalian cell culture and primary cells is a must. Additionally, experience with basic molecular and cellular biology skills such as immunofluorescent imaging, PCR, Western Blotting, knock-in/knock-out is required. Experience in advanced in vitro platforms such as 3D cell-culture and microfluidic systems is a big plus.
Experience with liver, kidney, GI, and immunology highly desired.
Hands-on experience in oligonucleotide therapeutics, cell and gene therapies will be a big plus.
Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for de-risking drug candidates.
Strong track record of external publications in peer-reviewed journals and presentations at national/international meetings.
Experience working in a matrixed team environment at a pharmaceutical company and/or CRO.
Experience in assays related to in vitro safety biomarkers, transporters, and P450 enzymes is a plus.
Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
Demonstrate strong decision-making, complex problem solving, and critical data analysis skills.
Effectively communicates scientific findings to the team across the organization in oral and written format.
Strong interpersonal and organizational skills.
DABT certification a plus, but not necessary
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Tuition reimbursement Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Discover more at takedajobs.com
No Phone Calls or Recruiters Please.
Job ID R0012516