Staff Scientist 1

Affymetrix - San Diego, CA (30+ days ago)3.9

Affymetrix, now part of Thermo Fisher Scientific

Scientist I – Conjugation Chemist

We are seeking a highly motivated individual to join the Bioconjugation Product Development Group within the Research & Development Department. The ideal candidate in this role will be responsible for developing and optimizing the conjugation chemistry and purification methods of antibodies to cutting edge materials. Necessary skills for this position will include UV-Vis Absorption, photoluminescence, HPLC and FPLC chromatography (size exclusion, HIC, protein G, etc.), dynamic light scattering, computer analysis and mathematical computation, etc. Our products are used in Flow Cytometry, immunohistochemistry, and other cell analysis applications.

The Bioconjugation Product Development Group works with new materials and fluorophores toward the development of novel bioconjugates. We are a results driven team, working at a fast pace and looking for an additional hardworking and self-motivated member with steady hands and reproducible results.

Primary Duties and Responsibilities:
  • Spectroscopic characterization of new materials: Absorption spectroscopy, fluorescence spectroscopy, quantum efficiency, Dynamic Light Scattering
  • Antibody conjugation to polymeric materials and surfaces
  • Chemical surface modification of colloidal particles
  • Conjugate purification: size exclusion chromatography (SEC), Affinity Chromatography, etc.
  • Purification method development for new material conjugates
  • Drafting Work Instructions and aiding with technology transfer to Process Development and Manufacturing groups
  • Follow existing protocols and accurately document conjugations on batch records
Job Dimensions
Enthusiastic and motivated collaborator with strong interpersonal communication skills
Significant skills in mainstream computer software, especially spreadsheet-driven data analysis and graphing
Good communication (written and oral) skills and the ability to work in a multidisciplinary team environment are essential.
Work within a small team of other Scientists and Research Associates.
Position requires mild physical lifting and constant mobility around the lab
PhD in Organic Chemistry or Physical Chemistry preferred, but other disciplines may be considered
1-2 years Industrial Experience or equivalent
Preference will be given to candidates with industry or academic experience in the areas of Organic, Analytical or Bio-chemistry

Physical Demands and Work Environment:
The physical demands and work environment described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to sit, stand, walk, talk and hear; use hands to handle or feel; see computer screens and read computer printouts; and reach with arms and hands.

Noise level in the environment is moderate.

Affymetrix, now a part of Thermo Fisher Scientific is an EEO/AA Employer of Minorities/Females/Veterans/Disability/Sexual Orientation and Gender Identity