Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.
We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.
Vividion was ranked #2 mid-size company on The San Diego Union-Tribune's 2022 and 2023 Top Workplaces list.
We are seeking a highly motivated, experienced scientist to join our Immunology team to support the expanding portfolio of small molecules targeting autoimmune diseases. The Principal Scientist will report to the Director, Immunology and will be responsible for exploratory translational work to support indication selection and biomarker strategy for programs at the pre-IND stage. The individual will establish biomarker assays, execute mechanism of action studies, and work closely with the discovery research team to propose a translational strategy for the programs. The ideal candidate will have a broad scientific background with demonstrated experience in exploratory translational research to support immunology and autoimmune disease programs.
Essential Duties and responsibilities:
Design and execute exploratory translational studies to support translational strategy for the project
Work closely with the discovery research team to implement translational assays
Stay abreast with the latest literature and recommend translational strategies that will increase the confidence in therapeutic hypothesis
Development and/or use of new technology and assays to support translational efforts
Interpret experimental results and present work as well as strategy at company meetings
Prior experience in supporting exploratory translational work for autoimmune indications
Closely interface with program Leads and leadership teams to align with program strategy, timelines, company goals and deliverables.
Education and Experience requirements:
Ph.D. in immunology, cell biology, and/or molecular biology with 8+ years of relevant industry experience
Expert knowledge of adaptive and innate immunity, including the roles of various immune cells and cytokines in immune regulation and understanding of biological principles underpinning immunological diseases
Required technical skills include a strong in vitro immunology skill set which includes primary cell isolation and culture, assays with primary immune cells (T cells, myeloid cells), multiparameter flowcytometry, gene expression based and other novel technologies to support translational assays
Experience in designing and executing translational assays to support clinical translational strategy for autoimmune/inflammatory disease
Experience in bioinformatics and analysis of RNA-seq/omics data a plus
Pay & Benefits:
The annual base salary for this position ranges from $150,000 to $163,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance. Relocation assistance may be available based on business needs and/or eligibility.
EEO & Employment Eligibility:
Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.