Sr. Associate Scientist

Alnylam - Cambridge, MA (30+ days ago)4.6



Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with unmet need. Our first medicine, the first-ever RNAi therapeutic, has recently been approved by the FDA in the US for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and by the European Medicines Agency in the EU for the treatment of hATTR amyloidosis in adults with stage 1 or stage 2 polyneuropathy. In addition, Alnylam has four investigational medicines in late-stage development. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work in 2015, 2016, and 2017.

We are currently seeking an experienced and highly motivated Neuroscientist who shares our passion for the promise of RNAi therapeutics to join us at the Senior Associate Scientist level. The successful candidate will work with our multidisciplinary CNS team to identify and optimize siRNAs targeting disease of the CNS and work to advance our CNS platform. They will have a strong background in neuroscience with a focus on cell based and in vivo assays.

Summary of Key Responsibilities
Contribute to our effort to advance RNAi for CNS delivery
Assay development for CNS biology including cell based and biochemical assays
Perform in vivo experiments to advance our programs and platform
Work with the team to optimize screening of CNS targets from primary and derived cells
Work with our high throughput screening team to drive selection of candidate molecules targeting diseases of the CNS
Contribute to assay development for potential CNS biomarkers

Requirements include a B.S. or M.S. in an appropriate biological discipline such as neuroscience, pharmacology, genetics or molecular/cellular biology.
At least 4 years of experience in an academic or industrial setting are required, with demonstrated expertise in CNS biology.
Experience working in animal models of CNS disease, including dosing animal through a variety of routs of administration is required.
Prior experience working with, or developing models of CNS disease and elucidating disease mechanism of action would be helpful.
The candidate must be self-motivated, flexible, able to thrive in a team environment, and be comfortable working on multiple projects.
The candidate should have strong verbal and written communication skills and be capable of routinely interpreting data and making presentations to diverse groups within Research and Development.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.