The Therapeutic Discovery organization is seeking a talented and motivated individual to join the Bioassay & Profiling group within the Discovery Technology department in South San Francisco. The successful candidate will be a bench-scientist and will be expected to contribute to the advancement of Amgen’s early-stage drug discovery efforts by developing & validating cell-based & biochemical assays using a variety of scientific techniques & approaches.
Primary responsibilities will include generating cell lines that over-express targets of interest, maintaining cell lines in culture, testing small molecule therapeutics for activity on multiple targets, demonstrating target engagement by ligands, analyzing and organizing data, as well as interpreting and communicating results to research teams across multiple sites.
The successful candidate will interact closely with other researchers in a mentoring and/or role model capacity. The successful candidate will be expected to adjust and adapt new knowledge into practice. Additional responsibilities will include participating in external scientific meetings and keeping current with field of expertise, including scientific literature and cutting-edge technologies.
Master’s degree and 4 years of scientific experience
Bachelor’s degree and 6 years of scientific experience
Pharmaceutical/biotechnology industry experience in drug discovery in the areas of cardiometabolic disorders, oncology or neuroscience, with an emphasis on assay development to enable high-throughput screening (HTS), hit characterization & lead optimization
A thorough practical & theoretical understanding of the principles of structure-function relationships, molecular biology, physiology & pharmacology of diverse target classes and an ability to apply this knowledge creatively to resolve scientific & technical challenges on early-stage projects
Broad experience & expertise in molecular & cellular reagent generation and in the independent development & implementation of cell-based activity or high-content assays (e.g., second messenger generation, ion flux, reporter gene activation, cellular imaging) coupled with an ability to establish compelling links between ligand activity and target engagement in a cellular context (e.g., CETSA)
Experience in biochemical assays (e.g., enzymatic activity, molecular interactions, protein modifications) &/or biophysical techniques & approaches (e.g., SPR, ITC, MST, TSA etc.)
Experience in the setting-up & operation of fluorescence/luminescence plate readers (e.g., FLIPR, EnVision) and automated liquid handlers (e.g., Bravo, Echo, Washer/Dispenser II) in the development of 384- &/or 1536-well microtiter plate assays
Experience with software platforms for the analysis if large datasets (e.g., Screener, Spotfire, Pipeline Pilot)
Ability to design & execute creative, high quality experiments independently and to interpret & communicate/explain results in a fast-paced team environment while paying attention to project timelines & priorities
Enthusiastic interest in and awareness of the latest trends and developments in bioassay & screening technologies
Highly motivated, innovative, proactive & enthusiastic team player demonstrating flexibility, a willingness to learn & a great sense of urgency
An ability to prioritize effectively & utilize resources efficiently coupled with strong organizational, interpersonal as well as verbal & written communication skills
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.