Research Associate (Postdoc) to work in David Morgan's biomedical research laboratory on causes and treatments of Alzheimer's disease. Pay scale will be equal to NIH NRSA awards depending upon years of experience. Seeking highly motivated individual with capability of working independently. Applicant will also be trained in grant writing and managing an NIH funded research laboratory.
This position will work on an NIH funded project to understand the role of neuroinflammation in moderating the pathologies found in the Alzheimer's disease brain. This project will use existing mouse models of tauopathy and amyloid deposition, and will also include measures of inflammation markers from human CSF samples. Aims of the project will investigate the role of systemic immune activation on the extent of tau pathology in mice of different ages. Some of the studies will require small animal surgeries, experiments in cultured cells and production of adeno-associated viral vectors. Measurements will include assessments of mouse behavior, analysis of histological sections, and neurochemical measures of markers of pathology and inflammation. The laboratory is very well equipped with new instrumentation including a Zeiss Axioscan digital scanning microscope. a Biorad Chemidoc Gel imaging systems, a Quanterix Simoa automated Elisa instrument, a mouse behavior core facility, and a shared Thermo Scientific LC/MS core. In addition to laboratory research, the fellow will be trained in the afomrat used to write research grants, the ability to manage multiple projects simultaneously and the supervision of 2 or more personnel working on your projects. Training will also be provided in how to develop 1 hour lecture for scientific and educational purposes.
The position requires a doctoral degree in a biomedical research discipline which included at least 4 years of experience in a research laboratory. Individual should be familiar with common biological laboratory research practices and have a basic understanding of biochemistry, molecular biology, cell biology and physiology. Applicants should be experienced with being able to conduct research studies independently, scientific record keeping, collections and analysis of figures and tables, fundamental statistical analysis, and the format of preparing results for publication as a scientific manuscript. Good command of spoken and written English is a requirement
Training in the discipline of neuroscience is highly desired. Past experience in the field of Alzheimer's research is also highly desired. Experience with some or all of the following techniques will also be desired; testing of mouse behavior; tisssue collection techniques such as brain dissection, blood collection, CSF collection; histological sectioning, staining and analysis; neurochemical measurements by western, northern, southern blotting, Elisa methods; small animal surgery techniques, especially intracranial injections; molecular biology techniques such as cloning and viral vector production, PCR techniques; cell biology techniques such as transient transfections, development of stable transfected cell lines, differentiation of iPSCs into neural cell types. Ability to analyze big data sets from methods such as RNA Seq or Mass spec based proteomics would also be desirable.
Required Application Materials
Curriculum Vitae, names and contact information of 3 references, 1-2 page statement highlighting past acomplishemnts and stating goals for the next 10 years.
Review of Applications Begins On
Summary of Health Risks
Work with animals or unfixed animal tissue.
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