Biologist Project Scientist

Lawrence Berkeley National Laboratory - San Francisco Bay Area, CA (30+ days ago)4.2


Berkeley Lab’s DOE Joint Genome Institute has an exciting opportunity for a Biologist Project Scientist with a strong background in synthetic biology, molecular biology, cloning, and data analysis. Under general supervision, you will have a key role within the Agile BioFoundry (ABF) to coordinate the construction of pathways for the biological production of valuable compounds.

The candidate should be very experienced with state-of-the-art synthetic biology design tools (such as j5, BOOST, DIVA, ICE, RBScalculator) and be able to coordinate and communicate with customers to accurately define and document design specifications. You will have experience in troubleshooting difficult to complete constructs, as well as synthetic constructs that do not perform as expected from a functional standpoint. You must be able to interact with stakeholders and to propose alternative designs.

Specific Responsibilities:
Communicate with customers to define design specifications and construction strategies

Enter design specification in appropriate software tools to generate construction workflows

Conduct or oversee the current processes of generating synthetic DNA molecules and provide feedback for areas of improvement

Manage project workloads with other Build staff to ensure that appropriate timelines are communicated and met

Interact with the Instrumentation support group to develop new methods to support process scale-up

Attend and present findings in external meetings and conferences as well as meeting with funders and senior management

Responsible for analyzing sequencing data and for coordinating cell culture, and the preparation of samples for proteomics, metabolomics, and other cellular assays.

Interact with other groups for the seamless transfer of samples for the analysis of strains through various platforms including proteomics, metabolomics and any other relevant phenotyping assay

Responsible for executing or overseeing the construction process and documenting all the QC steps in the appropriate LIMS.

Desired Responsibilities:
Support ABF managers as necessary for report preparation, meeting organization or other ABF tasks

Propose new research projects to attract new funding and/or participate in multi-PI grant preparation

Required Qualifications:
PhD in Microbiology, Molecular Biology, Biochemistry, Genetics, or related field

Demonstrated experience with the use of multiple Synthetic Biology design tools

Experience in handling, transforming and culturing microorganisms is essential for this job. In particular, knowledge and experience in assembling large DNA molecules using different assembly methods would be an advantage

Extensive experience of advanced DNA cloning technologies and genomic research

Three to five years experience post-graduation in experimental design and methodologies for DNA cloning, sequencing, and sequence analysis

Demonstrated understanding of how scientific principles apply to problem being studied

Demonstrated ability to interact well with members of a multi-disciplinary research team and have strong written and oral communication skills

Experience in complex protocol development and optimization procedures

Experience with other functional genomics technologies including CRISPR/Cas9, miRNAs, and TF binding assays

Additional Desired Qualifications:
Experience with automated liquid handling systems

Experience in working with large DNA molecules

The posting shall remain open until the position is filled.

Notes:
This is a full time 2-year term appointment with the possibility of extension based upon satisfactory job performance, continuing availability of funds and ongoing operational needs

Full-time, M-F, exempt (monthly paid) from overtime pay.

Salary is commensurate with experience.

This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.

DOE Joint Genome Institute (JGI) — 2800 Mitchell Dr., Walnut Creek, CA.

Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science.

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