U.S. Environmental Protection Agency (EPA)
How to Apply
A complete application consists of:
Transcript(s) – For this opportunity, an unofficial transcript or copy of the student academic records printed by the applicant or by academic advisors from internal institution systems may be submitted. All transcripts must be in English or include an official English translation. Click here for detailed information about acceptable transcripts.
A current resume/CV, including academic history, employment history, relevant experiences, and publication list
Two educational or professional recommendations
All documents must be in English or include an official English translation.
If you have questions, send an email to EPArpp@orau.org. Please include the reference code for this opportunity in your email.
6/1/2020 3:00:00 PM Eastern Time Zone
- Applications will be reviewed on a rolling-basis.
Up to three research opportunities are currently available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), National Health and Environmental Effects Research Laboratory (NHEERL), Integrated Systems Toxicology Division (ISTD) in Durham, North Carolina.
In this training opportunity, the research participant will gain experience in using a complex human cell-based new assessment model (NAM) that biomimics aspects of human embryogenesis to evaluate chemical effects. The research participant will gain experience using complex cellular models such as spheroids, organoids, chip-based culture models and microphysiological systems. The complex cell models to be established will biomimic a process of embryonic development or the anatomical and physiological organization of a tissue. The research participant will have the opportunity to evaluate biochemical, transcriptional and cellular endpoints using an array of tools such as confocal microscopy, high content imaging and RNA sequence analysis. The research participant will gain knowledge in the field of systems developmental toxicology and will be a member of the Virtual Tissues Models research team. The research will be performed in collaboration with other team members conducting research on computational models focused on the same process or tissue.
The types of NAMs that are currently under development or consideration are tissue fusion, endothelial mesenchymal transition, flow-mediated endothelial cell function and new assessments of stem cell differentiation. A microphysiological system (MPS) model of human pregnancy that includes maternal, placental and embryonic compartments is being considered. MPS tissues such as placenta, neurovascular unit (blood-brain barrier), and neural plate are of interest to the research team. Once established, the application of NAM will be verified by prototypic compounds and used to evaluate high-priority chemicals of interest to the project to support program partners or the new TSCA.
The mentor for this research opportunity is Sid Hunter (Hunter.firstname.lastname@example.org).
Anticipated Appointment Start Date:
This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. The initial appointment is for one year, but may be renewed upon recommendation of EPA and is contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at EPA in the Durham, North Carolina, area. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits.
Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA. OPM can complete a background investigation only for individuals, including non-US Citizens, who have resided in the US for the past three years.
The qualified candidate should have received a doctoral degree in one of the relevant fields, or be currently pursuing the degree and will reach completion by the start date of the appointment. Degree must have been received within five years of the appointment start date.
First hand experience with a human complex cell culture model
Knowledge of micro-physiology models
Human cell culture experience
Knowledge of molecular signals in developmental biology
Experience of tissue culture techniques
Experience in evaluation of chemicals using a human complex cell culture model
Experience in collaborative bench and/or computational research
Single cell RNA seqeuncing experience
U.S. Citizen Only
Doctoral Degree received within the last 60 months or anticipated to be received by 1/31/2020 11:59:00 PM.
Earth and Geosciences (1 )
Engineering (1 )
Environmental and Marine Sciences (1 )
Life Health and Medical Sciences (9 )
I certify that I have lived in the United States for the past three years.