Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.
To enable Guardant Health to lead the disruption of cancer, a Guardant360® assay development team is seeking a highly motivated, Senior Scientist to develop and validate cutting edge Guardant360® genotyping assays for advanced stage cancers. You will work closely with scientists and process engineers on the team as well as cross-functionally with members from bioinformatics, operations, software, quality, and regulatory affairs. You may be hands on in the lab and will design, implement, and validate novel assays for cancer treatment selection. You will be expected to drive cross-functional projects and meet timelines. The ideal candidate will have strong communication skills, proven track record of NGS assay development, experience with assay validations, and a deep technical understanding of NGS assays and NGS data analysis.
Essential Duties and Responsibilities:
Design, execution, analysis, and documentation of hypothesis driven experiments to develop innovative NGS-based oncology assays
Have ownership of assay development deliverables within a cross-functional team including process engineering, operations, bioinformatics, and software.
Explore new technologies to drive assay improvements and develop new assays
Document product development requirements, development reports, SOPs, and validation results
Be highly committed to deliver results in a fast-paced and dynamic start-up organization within Guardant Health
Present data, proposals, and progress in various forums and to technical and non-technical audiences
Mentor junior members of the team and be committed to helping foster the scientific growth of the team
6+ years’ experience in development and validation of sequencing-based genomic assays in industry
Deep technical understanding of nucleic acid chemistry and NGS sequencing technologies
Strong data analysis skills and extensive experience with NGS data analysis tools such as Python or R
Demonstrated success in a fast-paced, dynamic, and result-oriented work environment
High attention to detail, with the ability to create clear and concise technical documentation
Demonstrated ability to organize and communicate complex information in a clear and concise manner to cross-functional audiences
Consummate team player:
- A highly motivated self-starter and innovative problem solver
demonstrated ability to contribute in an environment where numerous inputs are required to accomplish complex goals
Experience developing DNA or RNA NGS assays from a variety of source material in support of liquid biopsy assay development.
Experience with epigenomic assay development including DNA methylation
Experience with assay development for automated liquid handling platforms
Ph.D. in Molecular Biology, Genetics, Biochemistry or related field, or equivalent work experience
Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.
Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
All your information will be kept confidential according to EEO guidelines.
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