Research Laboratory Manager

Massachusetts General Hospital(MGH) - Charlestown, MA4.3

30+ days agoFull-time
The Research Manager, under general the supervision of the principal investigator, carries out a broad range of research activities and procedures, administratively oversees the running of the research laboratory (including management of research technicians), and manages spending and budgets of the portfolio of grants that fund work in the Suvà lab. S/he performs lab procedures with speed, method, precision and understanding of theory behind tests and procedures, works independently with minimal supervision. Has the ability to critically evaluate their own results and suggest alternatives and future experiments. Ensures efficient operation of the Suvà laboratory with administrative oversight over all lab functions. Allocates, budgets, and regulates spending on the multiple grants that fund work in the Suvà lab and contributes to the assembly of progress reports to funding agencies.

Responsible for performing and training new lab members in specific research techniques including but not limited to:
Isolation of viable cells from tumor specimen.
Mastery of techniques for performing single-cell genomics (single-cell RNA-sequencing, single-nucleus RNA-sequencing, single-cell DNA-sequencing).
Mastery of various molecular biology techniques including but not limited to: PCR/RT-PCR, primer design, PCR troubleshooting/optimization, RNA isolation, RNA quantification, site-directed mutagenesis, Gibson assembly, and restriction digestion-mediated cloning of DNA fragments
Design and ordering of oligonucleotides
Performing and troubleshooting high-throughput genotyping assays
Maintenance of various human somatic cell lines
Transfection of various human somatic cell lines with DNA, mRNA, and/or ribonucleoprotein using multiple techniques (e.g., Nucleofection, Lipofectamine)
Viral transduction of mammalian cell lines
Isolation of genomic DNA from cultured human cell lines
Perform multiplexed or high-throughput versions of assays
Analysis of sequencing data
Presenting results, techniques, and pertinent information at weekly laboratory meetings and directly to the PI.
Administrative lab management and operation responsibilities
Oversight over operation of ~10 member research laboratory
Responsible for laboratory safety including serving as lab safety officer, training of all new lab members, maintaining biohazard and human studies permitting and paperwork
Responsible for administrative aspects of all laboratory collaborations including signing of required material transfer agreements, conflict of interest letters, and shipping of materials.
Responsible for maintenance of all laboratory equipment and service contracts
Oversight of research technicians and their administrative responsibilities
Coordinate service visits with robot manufacturer field engineers
Responsible for screening, interviewing, and hiring of new laboratory technicians and technologists
Responsible for performance management of staff including evaluations and corrective action as needed.
Responsible for financial management of the lab
Oversight of budgets for the portfolio of multiple grants that fund research of the Suvà lab
Determine spending for each grant including personnel costs, supplies, services, major equipment
Track spending and produce monthly report for each grant
Responsible for all purchasing decisions, negotiation of standing and one-time quotes, and identifying opportunities to reduce costs of reagents and implement/validate alterations to protocol
Prepare progress reports for funding agencies
Assist Dr. Suvà with the preparation of new grant proposals including the preparation of budgets and budget justifications

Performs other duties or special projects that are appropriate to this level of position.


Education :
Bachelor’s degree in biological science is required; Master's or PhD degree is preferred.

Experience :
A minimum of seven years of experience in biological research, and experience managing laboratory budgets and purchasing.

Skills/Abilities/Competencies Required :
Demonstrated knowledge of basic and advanced lab equipment functionality and capability, including skills necessary for basic operation and maintenance.
Ability to work independently and as a team member
Analytical skills and ability to independently resolve technical problems
Ability to effectively supervise others
Ability to critically interpret acceptability of data results
Advanced knowledge of data management programs
High degree of computer literacy
Demonstrated excellence in research techniques and methodologies
Excellent teamwork and communication skills.
Good organizational skills to handle multiple tasks in a busy environment.
Capabilities to manage and train lab members in safety, methods, and equipment use
Ability to manage multiple grants including: budgeting of spending for supplies, personnel costs, and services; reconciling fund balances on a monthly basis; making purchasing decisions for major equipment; negotiating standing and one-time quotes; and preparing progress reports for funding agencies and sources
Ability to research technicians who perform other lab administrative functions (safety, purchasing/ordering, service contracts, and basic lab organization)
Ability to manage and maintain multiple research collaborations including overseeing MTA paperwork, conflict of interest forms, and shipping of lab reagents.

Su pe rvisory Responsibility :
Supervise research techs I and II in their execution of lab administrative functions. Number of techs is variable but typically will be 3-4 at any given point in time.

Fiscal Responsibility :
See responsibilities listed above. Annual direct cost budget of the Suvà lab is about $1 million.
EEO Statement
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.

Primary Location
: MA-Charlestown-13th Street - MGH
Work Locations
13th Street - MGH
149 13th Street
Charlestown 02129
: Research-Management
: Massachusetts General Hospital(MGH)
: Full-time
Standard Hours : 40
: Day Job
Employee Status
: Regular
Recruiting Department : MGH Molecular Pathology
Job Posting
: Jul 25, 2018