- Next Generation Sequencing
- Experimental Design
- Molecular Biology
About the Role
You will play a key role in shaping and organizing the culture of efficiency within the clinical laboratory and broader operations. You will take point position in optimizing our automated diagnostic product and supporting processes to allow Freenome to prepare for multiple stages of scale-up in an elegant fashion. Your responsibilities will include programming and testing lab automation, developing principled design considerations to come up with effective processes based around molecular biology requirements. You will be directly responsible for the implementation of robust processes on robotic systems (Bravos and Hamiltons), and represent process engineering and automation around the company, including the following groups: supply chain, regulatory, technology transfer, software engineering, wet R&D.
You will be in charge of growing the process engineering and laboratory automation expertise within the company, including through hiring, covering the following groups: robotics, process engineering, support and service.
Additionally, in the early stages of the company, you will support laboratory training, service of instrumentation, and if absolutely needed, sample processing in the R&D context.
You have a strong work ethic, know the value of your contribution and want to make an outsized impact by helping the development and mass-marketing of a life-changing test on the operational side.
You're a seasoned molecular biologist, have designed and supported workflows, and know everything in between. The laboratory touches multiple fields: enzymatics, manufacturing, software, IT, etc… You're well versed in these areas and can participate significantly in all parts of the operation.
The challenges of a startup are exciting and you realize the world-changing value of circulating tumor DNA screening. Freenome is changing the world through a product that has the potential to better the standard of care for all current, future and potential cancer patients. Our ability to build and maintain scalable and efficient workflows in a clinical environment to deliver an always better product will be the main driver for adoption and you will be a key stakeholder in the success. We need to do it quick, we need to do it fast, and most of all we need to do it well. You believe you are up to the task and want to prove it.
You work well with others. The automation team is a service provider to the laboratory teams, and the balance between bringing new ideas and processes to the table with managing existing ones and gathering ideas/requirements from the end users will be a critical part for the success of the automation team.
Lead and/or participate in the design and implementation of efficient workflows, from receiving of labware and reagents to the generation of reports, in support of a rapidly growing clinical organization
Design and execute optimization experiments for the execution of molecular biology processes on robotic platforms
Continuously assess the state of the operations and prioritize improvements based on expected improvements
Grow into owning the COGS improvements pipeline
Plan for critical technology shifts to minimize short and long term costs (e.g. 96 to 384 samples/batch)
Lead and mentor more junior talents in a wide array of technologies, including laboratory automation, industrial motion, technical design and design reviews, experimental design and planning, etc...
Integrate or build innovative laboratory automation tools, instruments and technologies
Design the development of new, automated and efficient lab processes, with the end goal of processing the world's volume of genetics tests hands free.
Bring a can do attitude to solve new and challenging problems in a high pace environment
Be a key stakeholder in building a world-class automation team.
Participate from the inside in the development of a high growth startup.
Perform other related duties as assigned and based on company needs.
What We're Looking For
3+ years developing and implementing high-efficiency workflows for molecular biology, ideally on robotic systems
Strong working knowledge of molecular biology and NGS sequencing
Proven track record in developing and maintaining robust and efficient workflows, with a particular focus on QCs
Successful transfer of technologies and workflows into a high-throughput operation
Experience scripting methods on OEM robotic systems (Tecan, Hamilton, Beckman, etc…)
Functional knowledge in experimental design, bench execution, process optimization, data analysis
A good sense for laboratory automation technologies to lead a lab automation team
Hardware and internal support expertise to lead a service team
Proven organizational sense to develop an efficient and integrated service, automation and process engineering groups
Nice to Haves
Expertise in oncology, immunology, developmental biology, or similar applied fields
Experience working with NGS data
Broad experience in nucleic acid processing: whole genome, RNA, targeted enrichment
Experience working with a broad set of instruments and data: sequencers, mass spec, qPCR, microscopes, etc
Experience with software engineering best practices: code quality, testing, performance optimization, development of research tools infrastructure
Experience working in a regulated environment (CLIA / CAP / NYS / FDA / GCLP)
Experience in reagent manufacturing, ideally in a regulated environment (cGMP)
Freenome is on a mission to empower everyone with the tools they need to detect, treat, and ultimately prevent diseases.
By applying advanced machine learning techniques to recent breakthroughs in genomic science, Freenome is developing simple blood tests to detect early-stage cancer and make treatments more effective. The company has raised $238 million from investors such as RA Capital, Polaris Partners, Perceptive Advisors, Andreessen Horowitz, funds and accounts advised by T. Rowe Price Associates, Inc., GV (formerly Google Ventures), Roche Venture Fund, Kaiser Permanente Ventures, American Cancer Society's BrightEdge Ventures, Data Collective Venture Capital, Novartis and Verily Life Sciences (formerly Google Life Sciences).
Freenome is building technology to gain an understanding of the body through several analytes derived from blood. These signals include cell-free DNA, methylation of cell-free DNA, cell-free RNA, circulating proteins, and immune profiling derived from thousands of prospective samples. By developing novel statistical learning methods and applying them to integrate various -omics datasets, Freenome is a leader in modeling specific biological mechanisms to capture disease dependent signatures such as gene expression, immune response, tumor burden, the tissue of origin, and 3D chromatin structure.
By building comprehensive discovery datasets and modeling critical biological systems, Freenome is learning what biological changes are present within the blood between a variety of different disease states including cancer, autoimmune disorders, infections, drug response, and aging. With the combination of Freenome's datasets, cross-functional technical expertise, and mission to uncover the biological truth, we seek to positively change the lives of millions through the early detection and early treatment of disease.
Freenomers are technical and creative, visionary and grounded, empathetic and passionate. We build teams around divergent expertise, which allows us to solve problems and uncover opportunities in unique ways. Freenomers are some of the most talented experts in their fields, coming together to advance healthcare one breakthrough at a time.
We value empathy, integrity, and trust in one another. That means embracing other's perspectives, those of our coworkers and those of the patients and communities we serve. It means knowing when to push, and when to listen. At Freenome, we give each other the benefit of the doubt in the belief that we're all working as a team toward the same goals, and empower others to grow in a collaborative environment.
What does a successful person look like at Freenome?
Those who thrive at Freenome prioritize, manage, and execute their own goals in alignment with those of the company. They embrace our values of empathy, integrity, and trust, and hold themselves and their team accountable. They crave collaboration with brilliant minds from unfamiliar fields of study and believe that hiring and mentorship are fundamental to our success. Above all, they welcome and provide constructive feedback and criticism, trusting in the good intentions of others, and secure in the knowledge that embracing mistakes is the best way to learn and move on. For those who crave challenges, understudied problems, and the chance to see their work impact the lives of millions of people affected by cancer every year, there's no better place to be.
Freenome is proud to be an equal opportunity employer, we value diversity in every way. Freenome does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other basis covered by appropriate law.