USA - Pennsylvania - Upper Providence
Jul 15 2020
Are you looking for a challenging opportunity that allows you to leverage your technical expertise to accelerate delivery in Novel Human Genetics? If so, this Investigator role could be an exciting opportunity to explore.
The Investigator will be part of a drug discovery research team in Novel Human Genetics Research Unit at GSK R&D. This team will focus on the design and execution of preclinical studies to develop novel medicines for the treatment of chronic neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. In this role, the candidate will have the opportunity to be creative in establishing human cell based (2D or 3D) neurological models of inflammation and degeneration, developing live cell imaging and biochemical readouts, utilize gene editing and chemical tools to enable drug discovery programs.
The Novel Human Genetics Research Unit (NHG RU) was formed in 2019 to identify and advance novel targets with genetic association to disease based on the foundational observation that targets with human genetic evidence supporting their causal role in the intended indication improves clinical success by two-fold. The NHG RU is therapeutically broad and complements other research units with strategic focus in immunology and oncology. The current portfolio includes projects focused on neurological diseases, including Parkinson’s, Alzheimer’s, ALS, Pain, in addition to metabolic diseases. The mandate of NHG RU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform Phase 1 first time in human and proof of mechanism studies in clinic. This goal is enabled through strategic external (23andMe, UK Biobank, FinnGen, Laboratory of Genomic Research, Public-Private Consortia) and GSK-internal partnerships (Functional Genomics, AI/ML, and Medicinal Science and Technologies).
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
Establish and validate cellular models of neurodegeneration and neuroinflammation using human iPSC-derived and/or primary rodent neuronal co-cultures
Define, design, and perform pharmacology or genetic (e.g., CRISPR, shRNA) experiments in cellular models to validate targets and/or progress lead optimization projects for drug discovery
Conduct pharmacological studies with an array of techniques including next gen. sequencing, high-content imaging (OperaPhenix), immunoassays (ELISA, MSD, Quanterix), TaqMan, Seahorse, mass spectrometry, confocal microscopy among others
Independently execute laboratory experiments, conduct statistically supported data analysis, and deliver results in a timely manner to enable informed decision making
Clearly record and communicate study results at internal and external meetings
Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies
Comply with all standards and practices of data integrity, ethics, and safety
Model GSK’s values of patient-focus, respect, transparency, and integrity
We are looking for professionals with these required skills to achieve our goals:
PhD or MD/PhD with 1-2 years’ of experience in neuroscience or neuropharmacology
Outstanding cell, molecular biology, and biochemistry technical experience
Prior working experience with neurodegenerative or neuroinflammatory diseases (e.g., Alzheimer’s disease)
Hands on with hiPSC differentiation into neurons, microglia, and astrocytes, characterization, and in vitro disease modeling
Functional assay development interrogating endolysosomal, lipid metabolism, and immune processes in mono- and co-culture systems
High-content cellular imaging to characterize intracellular events impacting neuronal and glial cell health
Focused or genome-wide screens (e.g., CRISPR, shRNA), RNAseq, and integrated multiparametric data analysis
If you have the following characteristics, it would be a plus:
3+ years pharmaceutical or biotechnology industry research experience working in matrixed drug discovery project teams
Interest and agility (technical, conceptual) to navigate into different disease areas beyond neurodegenerative disease (e.g. metabolic disease)
Demonstrated experience of learning agility (conceptual, technical, team work).
Outstanding written and oral communication skills including record of scientific publications
Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
Continuously looking for opportunities to learn, build skills and share learning.
Sustaining energy and well-being.
Building strong relationships and collaboration, honest and open conversations.
Budgeting and cost-consciousness.
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