Senior Scientist

Merck USA - West Point, PA4.1

Requisition ID: BIO005251

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

We are seeking a Ph.D. level scientist with 0-3 years of relevant experience to join our Vaccine Analytical Development team located in West Point, PA as a Sr. Scientist. This incumbent should have expert knowledge in separation sciences with applications to large biomolecules such as viruses, lipid nanoparticles, polymers, proteins, DNA/RNA, and knowledge of biomolecule purification. Responsibilities include:

Developing, optimizing, implementing LC-based assays for recombinant proteins, lipid nanoparticles, conjugate & live-virus-based vaccines

Proactively applying separation technology to better characterize complex vaccines

Collaborating in a fast-paced, integrated, multidisciplinary team environment

Providing technical guidance to other scientists

Preparing technical documents to support regulatory submissions


Education Minimum Requirement:
PhD in Analytical Chemistry, Chemistry, Biochemistry, or a closely-related field

Required Experience and Skills:
In-depth knowledge and understanding of biochemistry and liquid chromatography (UPLC, HPLC) demonstrated by publications
Strong scientific & technical leadership skills
Good understanding of protein characterization techniques (ie. SDS PAGE, Western Blot)
Excellent verbal & written communication skills
Strong awareness of industry / regulatory trends
Knowledge of emerging technologies

Preferred Experience and Skills:
Experience with different types of UPLC/HPLC separation (SEC, IEX, HIC, RP, HILIC), CE (CE-SDS, cIEF, MEKC, CZE, CE-MS), and GC (GC-FID, GC-MS)
Experience with CAD and ELSD detectors
Experience with proteins, viruses, lipids, RNA and DNA separation and characterization (antigen-antibody interaction, glycoprotein properties)
Basic knowledge of protein purification (familiar with AKTA system) and protein chemistry in general
Understanding of GMP as applied to analytical requirement
Experience with lab automation
Supervisory experience
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to

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