Post Doctoral Research Fellow, Genome Engineering - Alzheimer's

Rush University Medical Center - Chicago, IL (30+ days ago)4.1


Job Title: Post Doctoral Research Fellow, Genome Engineering - Alzheimer's
Department: Alzheimer Disease Center
Shift: 1st
Specialty: Alzheimer's Disease
Job Number: 2017-2380
Date Posted: 10/29/2017
Position Type: Research

Job Qualifications:
The Rush University Alzheimer's Disease Center (RADC) is leading experimental and epidemiological center for the study of Alzheimer's disease, which has no preventative drugs, and is expected to soon triple in incidence. Over the past decade, the RADC has carried out numerous community-based cohort studies to better understand Alzheimer's disease and ageing, generating many omic data sets from human samples. Now we invite you to capitalize on this research to explore candidate genes and proteins have been identified to be relevant to Alzheimer's disease molecular pathology, though genetic engineering experiments.

Position Highlights:
As part of a major expansion into genome engineering, the Alzheimer's disease Center at Rush University is seeking highly motivated candidates for Postdoctoral positions in genome engineering and next generation sequencing. You will lead genome engineering experiments that will test the effect of novel genes on Alzheimer's disease, using innovative "cognition in a dish" and person-specific models. Our group has published in Science, Nature and Cell, and we expect that your research will be of similar high impact. Your research will have the unique advantage of utilizing the most clinically detailed and extensive collection of Alzheimer's brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer's cohorts. Examples of the rich data can be seen here and in many 1000+ citation papers. Additionally, this position offers:
Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer's datasets at Rush University
Thousands of post-mortem tissues available for person-specific AD models
Deeply phenotyped sample origins, with multiple omics, cognitive testing and neuroimaging
Sole access to the latest sequencing and cellular phenotyping equipment
Pursue highly novel targets and follow effects wherever they lead
Scientific focus in a flat organizational structure with stable funding
Career development and grant-writing opportunities alongside highly successful scientists

Position Responsibilities:
Lead and perform a number of advanced genomic lab techniques, including designing gRNA, delivering CRISPR/Cas9 to human stem cells, targeted clone validation and single cell cloning.
Evaluate off-target effects and validate stem cell properties after engineered lines have been established.
Oversee the day to day organization of different components of the projects.
Work collaboratively with other RADC teams who are working on related research questions.

Position Qualifications Include:
PhD or MD or equivalent degree in the fields of Molecular biology, Genetics, Functional Genomics, Biochemistry, Neuroscience or related fields
Experience in genome editing, molecular biology, next generation sequencing and single-cell RNA sequencing
Abilities in designing gRNA, delivery of CRISPR/Cas9 to human stem cells, targeted clone validation and single cell cloning
Excellent skills and experience in sterile techniques, cell and tissue culture and transformation
Experience in stem cell culture and differentiation is a plus
Demonstrated skills in project planning, organization, analysis and communication
Proven ability to work independently and in collaborative team environments

Company Highlights:
Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care.
Rush's 14-story hospital Tower is the cornerstone of the Rush Transformation, and is the symbol of a philosophy-an evolution in the delivery of patient-centered care.

Rush offers a competitive salary, valuable healthy living benefits to include: health, dental and vision to help you maintain and improve your health. Rush also offers several ways to invest in your future. Whether you're saving for retirement or a child's education, Rush offers benefits to help you make the most of your moneynow and in the future.

Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.

The Rush University Alzheimer's Disease Center (RADC) is leading experimental and epidemiological center for the study of Alzheimer's disease, which has no preventative drugs, and is expected to soon triple in incidence. Over the past decade, the RADC has carried out numerous community-based cohort studies to better understand Alzheimer's disease and ageing, generating many omic data sets from human samples. Now we invite you to capitalize on this research to explore candidate genes and proteins have been identified to be relevant to Alzheimer's disease molecular pathology, though genetic engineering experiments.

Position Highlights:
As part of a major expansion into genome engineering, the Alzheimer's disease Center at Rush University is seeking highly motivated candidates for Postdoctoral positions in genome engineering and next generation sequencing. You will lead genome engineering experiments that will test the effect of novel genes on Alzheimer's disease, using innovative "cognition in a dish" and person-specific models. Our group has published in Science, Nature and Cell, and we expect that your research will be of similar high impact. Your research will have the unique advantage of utilizing the most clinically detailed and extensive collection of Alzheimer's brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer's cohorts. Examples of the rich data can be seen here and in many 1000+ citation papers. Additionally, this position offers:
Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer's datasets at Rush University
Thousands of post-mortem tissues available for person-specific AD models
Deeply phenotyped sample origins, with multiple omics, cognitive testing and neuroimaging
Sole access to the latest sequencing and cellular phenotyping equipment
Pursue highly novel targets and follow effects wherever they lead
Scientific focus in a flat organizational structure with stable funding
Career development and grant-writing opportunities alongside highly successful scientists

Position Responsibilities:
Lead and perform a number of advanced genomic lab techniques, including designing gRNA, delivering CRISPR/Cas9 to human stem cells, targeted clone validation and single cell cloning.
Evaluate off-target effects and validate stem cell properties after engineered lines have been established.
Oversee the day to day organization of different components of the projects.
Work collaboratively with other RADC teams who are working on related research questions.

Position Qualifications Include:
PhD or MD or equivalent degree in the fields of Molecular biology, Genetics, Functional Genomics, Biochemistry, Neuroscience or related fields
Experience in genome editing, molecular biology, next generation sequencing and single-cell RNA sequencing
Abilities in designing gRNA, delivery of CRISPR/Cas9 to human stem cells, targeted clone validation and single cell cloning
Excellent skills and experience in sterile techniques, cell and tissue culture and transformation
Experience in stem cell culture and differentiation is a plus
Demonstrated skills in project planning, organization, analysis and communication
Proven ability to work independently and in collaborative team environments

Company Highlights:
Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care.
Rush's 14-story hospital Tower is the cornerstone of the Rush Transformation, and is the symbol of a philosophy-an evolution in the delivery of patient-centered care.

Rush offers a competitive salary, valuable healthy living benefits to include: health, dental and vision to help you maintain and improve your health. Rush also offers several ways to invest in your future. Whether you're saving for retirement or a child's education, Rush offers benefits to help you make the most of your moneynow and in the future.

Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.