Pfizer Inc. - Pearl River, NY4.2

Full-timeEstimated: $64,000 - $92,000 a year

The primary purpose of this position is to design, plan, and execute the diverse purification / recovery operations required for the production of the various vaccine candidates. These include development of scalable purification processes for proteins, multiprotein complexes, virus like particles, nanoparticles and mRNA using broad range of fractionation methods (centrifugation, ultra / diafiltration, etc.), and chromatographic techniques (affinity, ion exchange, hydrophobic interaction, immobilized metal, and mixed mode chromatography). In addition to process development, experience with in-process analytical techniques is highly desired. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.


  • Develop, optimize, and scale-up recovery/purification processes for isolation of vaccine candidates up to pilot plant scale.
  • Continuously evaluate each process and technique to assess its robustness, suitability and scalability. If necessary, introduce required modifications and improvements.
  • Develop in-process analytical methods to monitor process performance or solve process issues.
  • Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess Fermentation, Analytical, and Formulation Development groups.
  • Present problems and propose solutions in discussions with group members. Offer insights based on experience to group members to help solve existing problems.
  • Plan and prioritize related recovery / purification activities.
  • Coordinate purification activity support and serve as a point person for the Process Development group when required.

  • BS in Chemistry, Biotechnology, Engineering or related discipline with at least 4 years of academic, pharmaceutical, or biotechnology postdoctoral experience is necessary, or a relevant MS degree with 2 years relevant experience
  • A strong background in protein biochemistry, biophysics, and separation techniques is essential. Hands on experience with proteins, polysaccharides or mRNA is preferred.
  • Experience isolating/purifying proteins from both microbial and mammalian systems is preferred
  • Proficiency with personal computers including word processing, spreadsheets, PowerPoint and relevant scientific software is desirable. Strong verbal and written communication skills are required

  • Knowledge and ability to independently design, plan, and execute purification / recovery activities. These should also include the ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical / biophysical characterization methods.
  • Proficiency and ability to utilize various techniques such as FPLC / HPLC, UV-Vis, CD, fluorescence spectroscopy to isolate and, when necessary, characterize purified vaccine candidates.
  • Independently analyze and provide conclusions regarding experimental data generated
  • May also lead / direct junior colleagues within the group and facilitate scheduling of related activities to complete assigned tasks.
Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

1 (First Shift) (United States of America)
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.