Full Job Description
Postdoctoral Position in Exosomes and Epitranscriptome Research at Mount Sinai, New York
Two postdoc positions funded by the National Institutes of Health (NIH) and New York State Stem Cell Science (NYSTEM) are available immediately in the Exosomes and Epitranscriptome Laboratory of Dr. Susmita Sahoo at Icahn School of Medicine at Mount Sinai, New York, NY.
Dr. Sahoo’s laboratory conducts research in the field of cardiac regeneration, gene therapy and heart failure to investigate molecular and cellular signaling mechanisms. Current projects involve pre-clinical, translational and basic science research. Exosomes are biological nanovesicles secreted by cells that carry and transfer noncoding RNAs, to mediate local and distant microcommunication between cells, tissues and organs. Her lab was one of the first to study stem cell-derived exosomes and exosomal noncoding RNA-mediated angiogenesis and cardiac regeneration. PMID: 21835908; PMID: 24436429; PMID: 28298297; PMID: 27872050).
In the recent years, her laboratory has established a new line of investigation to study post-transcriptional mRNA/lncRNA modifications (epitranscriptome) in cardiac remodeling and regeneration. These studies have led to the discovery of a novel RNA-mediated regulatory layer in the pathomechanisms of heart failure (PMID: 29997116). We use state-of-the-art techniques such as methylated (m6A) RNA immunoprecipitation sequencing (MeRIP-seq), RNA-binding proteins (RBP) and immunoprecipitation (RIP-seq), bioinformatics analyses, flow cytometry, electron, super-resolution and confocal microscopy, virus-based gene deliveries, microfluidics-based isolation of exosomes, stable-isotope-labeling mass spectrometry (SILAC), mass-spectrometry, in vitro and in vivo imaging, live imaging and small (rats and mice) and large animal (pig) models to address scientific questions in an innovative way.
Preferences will be given to those experienced with (1) RNA biology, epigenetics and bioinformatics or (2) mouse models, surgeries, viruses, bioengineering and nanotechnology and (3) with good publication records. We are looking for independent, self-motivated individuals with excellent verbal and written communication skills with a PhD or MD/PhD in Biotechnology/Molecular Biology. The appointment will include a competitive salary and benefits (including Mount Sinai discounted housing for postdocs), a dynamic multi-disciplinary research environment with access to the Institute’s state-of-the-art facilities that includes in vitro and in vivo imaging, flow cytometry and small and large animal surgical laboratories.
More information about our research and researchers can be found here:
Interested individuals should send their curriculum vitae containing a summary of past accomplishments, a statement of future objectives and professional references by e-mail to the contact listed in the job post.
Job Type: Full-time
Salary: $59,000.00 to $62,000.00 /year
- Health insurance
- Dental insurance
- Vision insurance
- Paid time off