- Updated, March 20, 2020*: All interview and hiring processes will be postponed until later specified. At this time, we are still accepting applications.
The Scientist - Drug Design Computational Modeling for the Alzheimer’s Disease Drug Discovery Center (ADDD Center) within the Purdue University Institute for Drug Discovery will be responsible for computer-aided drug design. The Computational Modeler will work closely with members of the other technical research cores to analyze crystal and cryo-EM structures to identify druggable binding sites and then perform in silico screening (e.g. structure-based, similarity-based, etc.) to identify potential small molecule modulators. Additionally, this position will utilize structure-based design to guide the optimization of hit- and lead-compound series from targets co-crystallized with small molecule binders.
This position will be supported for the duration of the five-year contract of the ADDD Center.
Master’s Degree in Computational Chemistry, Computer Science or related field
Two (2) years of industry experience
Expert in drug design modeling software, preferably Schrodinger suite
Experience in performing large scale virtual screening
Experience optimizing compound series via structure-based drug design
Experience working with medicinal chemistry teams to identify and optimize lead compounds for animal and clinical testing
Ability to carry-out computational experiments in an independent manner with little supervision
Basic skills in communication, word processing, data entry, and data analysis
Familiarity with Microsoft Office software (e.g. Word, Excel, Powerpoint, etc.)
Experience in designing blood-brain-barrier penetrating compounds
Purdue will not sponsor employment authorization for this position
A background check will be required for employment in this position
Exempt (Not Eligible For Overtime
Defined Contribution Waiting Period
Purdue University is an EOE/AA employer. All individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply