Part-Time Physician Assistant/Nurse Practitioner (3 days per week)
Location: Houston, TX (In-Office)
Employment Type: Part-Time
About Us
We are a rapidly growing Site Management Organization (SMO) supporting clinical research sites across multiple therapeutic areas. Our mission is to improve access to clinical trials while delivering operational excellence to sponsors, investigators, and patients. As we continue to expand, we are seeking an experienced and motivated Physician Assistant/Nurse Practitioner to assist with clinical trials at various sites and patient recruitment and enrollment across our network.
Position Summary
We are seeking an experienced Part-Time Nurse Practitioner or Physician Assistant to serve as a Sub-Investigator across multiple clinical trials within our growing clinical research network 3 days per week. This role will provide hands-on medical oversight throughout the clinical trial lifecycle, including evaluation of potential participants, confirmation of study eligibility, clinical assessments, review of laboratory and diagnostic results, and ongoing assessment of subject safety. The Nurse Practitioner/Physician Assistant will work closely with Principal Investigators, Clinical Research Coordinators, sponsors, and medical monitors to ensure protocol adherence, sound clinical decision-making, accurate documentation, and compliance with applicable regulatory and sponsor requirements. The ideal candidate will bring strong clinical judgment, attention to detail, and an interest in applying their medical expertise within a dynamic clinical research environment.
In addition to medical oversight, this role will play an important role in patient recruitment and enrollment across the clinical research network. The Nurse Practitioner/Physician Assistant will leverage electronic medical records to identify potential study participants, conduct targeted chart reviews, develop and maintain study-specific patient registries, and work with SCLA staff and referring providers to improve patient identification and reduce screen failures. The role will also provide ongoing clinical guidance for prescreening and eligibility determination. The successful candidate will participate in investigator meetings, site visits, and sponsor calls, helping to strengthen both the quality and scalability of the organization's clinical research operations.
Key Responsibilities
- Serve as Sub-Investigator on multiple clinical trials, ensuring protocol adherence, subject safety, and regulatory compliance in accordance with sponsor requirements
- Perform and document clinical assessments, including medical history review, physical examinations, disease-specific evaluations and review of laboratory and diagnostic results
- Evaluate and confirm subject eligibility, including detailed review of inclusion/exclusion criteria and required washout periods
- Provide medical oversight during screening and study visits, including review of adverse events (AEs/SAEs), concomitant medications, and clinically significant findings
- Partner with Principal Investigator to ensure accurate medical decision-making, protocol interpretation, and timely response to sponsor and medical monitor queries
- Actively support patient recruitment and enrollment strategies across studies through clinical oversight and EMR-based identification
- Utilize electronic medical records to:
- Identify potential participants using ICD-10 codes and medical history
- Conduct targeted chart reviews to assess preliminary eligibility
- Build and maintain study-specific patient registries
- Collaborate with Clinical Research Coordinators (CRCs) to:
- Refine prescreening criteria and questionnaires
- Provide medical guidance on borderline eligibility cases
- Reduce screen failures through improved patient selection
- Engage with referring providers and internal clinical teams to increase study awareness and appropriate patient referrals
- Maintain working knowledge of investigational products, including:
- Mechanism of action (MOA)
- Drug class and safety profile
- Half-life and washout implications
- Route of administration
- Interpret and apply protocol-specific requirements related to:
- Disease activity measures
- Lab thresholds
- Imaging requirements
- Safety monitoring parameters
- Provide ongoing clinical guidance and training to CRCs, particularly in:
- Prescreening best practices
- Eligibility determination
- Medication and washout review
- Clinical documentation standards
- Participate in site initiation visits (SIVs), investigator meetings, and sponsor calls
· Contribute to development of network tools, including prescreening scripts, eligibility checklists, and recruitment procedures
Qualifications
Required
- Current, unrestricted Nurse Practitioner (NP) or Physician Assistant (PA) license in Texas, in good standing.
- Current national certification appropriate to the individual's professional designation (e.g., NCCPA certification for PAs or applicable national NP certification).
- Graduate degree from an accredited NP or PA program.
- Ability to serve as a Sub-Investigator on clinical research studies and meet applicable sponsor, regulatory, and institutional requirements. ICH GCP expects investigators to be appropriately qualified by education, training, and experience and to maintain appropriate documentation of those qualifications.
- Current BLS certification; ACLS certification preferred or required based on study population and site requirements.
- Strong written and verbal communication skills with the ability to effectively communicate with Principal Investigators, Clinical Research Coordinators, sponsors, medical monitors, referring providers, and patients.
- Strong attention to detail and ability to maintain accurate, timely, and compliant clinical documentation.
- Ability to work collaboratively with CRCs and provide clinical guidance regarding patient prescreening, eligibility, medication review, and clinical documentation.
- Ability and willingness to travel to clinical research sites throughout Texas, including periodic overnight travel as needed.
- Ability to participate in site initiation visits, investigator meetings, sponsor calls, and other study-related meetings.
Preferred
- Minimum 3 years of clinical experience as a Nurse Practitioner or Physician Assistant, preferably in an outpatient or specialty-care setting.
- Proficiency with electronic medical records (EMR) and electronic clinical documentation systems.
- Strong clinical assessment and medical decision-making skills, including the ability to evaluate medical histories, physical examinations, laboratory results, diagnostic testing, adverse events, and concomitant medications.
- Ability to interpret and apply complex clinical trial protocols, including inclusion/exclusion criteria, laboratory requirements, disease activity measures, imaging requirements, and medication washout periods.
What We Offer
- Competitive salary
- Health, dental, and vision benefits
- Paid time off and holidays
- Professional development opportunities
- Collaborative and mission-driven work environment
- Opportunity to contribute to a growing organization within the clinical research industry
Pay: From $70.00 per hour
Work Location: In person
