Position Objective: The Scientist will provide support services to satisfy the overall operational objectives of the National Institute of Allergy and Infectious Diseases within the National Institutes of Health.
Duties and Responsibilities:
- Work with Lab Operations group to optimize lab environment to maximize efficiency and reduce risk of product contamination or loss.
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Coordinate with other project members to ensure timelines and material production requests are met
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Develop mRNA-Lipid nanoparticle vaccines, through microfluidic and impingement jet mixing devices 1
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Purify research-phase recombinant proteins, virus vaccines and or virus-like particles in support of other groups at the VRC 2
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Support technology transfer of processes to VRC Pilot Plant for manufacture of clinical product including authoring process descriptions, reports, and on-floor support
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Develop novel techniques protocols for process development, including high-throughputandor robotics-based methods
- Perform protein small molecule conjugation experiments to support method develop mentor conjugate-based vaccine candidates
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Author training documents, instrument SOPs, and other equipment supporting documentation
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Author process documents to support toxicology lot production including batch records and process summary reports
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Analyze and compile data, present at various group department meetings
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Support the Purification group of the Vaccine Production Program VPP Labs of the Vaccine Research Center 3
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Develop downstream purification processes or recombinant proteins, virus vaccines, and virus-like particles VLP that may be used as clinical vaccine candidates
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Serve as a functional point of contact in chromatography process development unit operations
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Provide critical process step assessment and experimental design to define optimal process parameters for chromatography unit operations
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Train group members in large-scale unit operation such as AxiChrom column packing and Pilot-scale chromatography execution
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Work to prepare necessary materials buffers, packed columns in support of down stream process activities
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Perform protein-small molecule conjugation experiments to support method develop mentor conjugate-based vaccine candidates
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Facilitate consortium authorship efforts in project-specific technical reports and protocols
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Work independently and collaboratively within the purification group to design, develop and optimize chromatography and filtration step unit operations to support process development of clinical trial vaccine candidates and mAb products
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Analyze experimental data and interpret results to write reports and summaries of findings
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Coordinate the work of biological technicians and technologists and other scientists
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Operate, calibrate, or maintain equipment used in quantitative or qualitative analysis, such as spectrophotometers, calorimeters, flame photometers, or computer-controlled analyzers
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Maintain laboratory equipment
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Operate laboratory equipment to analyze samples
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Operate microfluidic mixer for lipid nanoparticle development studies Clean Equipment
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Work products and documents related to developing downstream processes for recombinant proteins, virus vaccines, and virus-like particles (VLP) that could be used as clinical vaccine candidates; serving as a functional point of contact in either chromatography or filtration (normal flow and tangential flow filtration) purification process steps for a given project.
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Work products and documents related to working with the Group members to design, develop and optimize purification process for all clinical trial vaccine candidates.
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Work products and documents related to writing and reviewing technical protocols and reports; purifying research-phase recombinant proteins, virus vaccines and/or virus-like particles in support of other groups at the VRC.
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Work products and documents related to developing novel techniques/protocols for process development, including highthroughput and/or robotics-based methods.
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Work products and documents related to performing protein/small molecule conjugation experiments to support method development or conjugate-based vaccine candidates; analyzing and compiling data, present at various group/department meetings.
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Meet with lab members to present updates
Basic Qualifications:
- Ph.D. degree in a scientific field or equivalent
- Minimum of six years of experience in a scientific related field
- Skilled in AKTA Unicorn and MS Office
Preferred Qualifications:
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Ability to communicate effectively, orally and in writing, with non-technical and technical staff
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Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
- This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job, email us at [email protected]. You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.
Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.
This position is contingent upon contract award.
