Research Associate/ Research Scientist – RNA Therapeutics & Nanomedicine
Research Associate and Research Scientist positions are available in Dr. Pradeep Chaluvally-Raghavan's Lab, Department of Obstetrics and Gynecology at the Medical College of Wisconsin. The laboratory investigates the role of RNA-binding proteins (RBPs) in tumor progression and the tumor microenvironment using advanced molecular, cellular, and animal models, with a primary focus on ovarian and breast cancers. Current research also emphasizes the development of RNA interference (RNAi)-based therapeutic strategies, including the design and optimization of siRNA formulations, lipid- or nanoparticle-based delivery systems for targeted gene silencing and proteolysis targeting chimera (PROTAC) linked with RNA (RNA-PROTAC). Please read the related publications from our lab to know more about the background of proposed research (Nature Communications, 2026, PMID: 41932914; Advanced Sciences, 2022, PMID: 35289120; and Cell Reports, 2021, PMID: 34731628).
The successful candidate will design and conduct experiments in both cell culture and animal models, develop and characterize siRNA-loaded nanoliposome formulations, and perform in vivo studies to evaluate biodistribution, target gene knockdown, therapeutic efficacy, and the translational potential of RNAi-based therapeutics for cancer treatment. Familiarity with protein structure and structure-function relationships will be considered an advantage for this position.
We are seeking highly motivated scientists with below expertise to fill this position:
· RNA interference (RNAi) and siRNA technologies
· RNA-binding proteins and RNA-protein interactions
· Lipid nanoparticles (LNPs) and nanomedicine
· In vivo cancer models and translational research
· Molecular biology and recombinant protein production
· RNA PROTAC (RNA-Proteolysis Targeting Chimera)
· Protein and RNA structures
The successful candidate will lead independent research projects, collaborate on laboratory operations, mentor trainees, develop innovative RNA delivery strategies, characterize RNA-RBP interactions, develop therapeutics target RBP and collaborate with a multidisciplinary team of scientists working at the intersection of molecular biology, nanotechnology, and cancer therapeutics.
Qualifications
Ph.D. in Cancer Biology, Molecular Biology, Cell Biology, Biochemistry, Pharmaceutical Sciences, Biomedical Engineering, or a closely related discipline.
Non-Ph.D. candidates with RNA-RBP research experience and publications will also be considered.
Required Experience: Recent Ph.D. and not more than 2 years of post-doctoral experience with strong track record of publications.
Please submit your CV and research statement to [email protected] if you are interested.
Pay: $60,018.50 - $84,323.36 per year
Benefits:
- 401(k)
- Dental insurance
- Health insurance
- Vision insurance
Work Location: In person
