National Institute of Neurological Disorders is now seeking a Staff Scientist to lead cutting-edge biophysical investigations of organelle chloride transport and its roles in neuronal function and disease.
Prospective candidates will join a multidisciplinary team of biophysicists, cell biologists, and structural biologists exploring the mechanisms that govern Cl homeostasis within intracellular organelles (such as lysosomes) and how dysregulation of this homeostasis contributes to neuropathology.
Candidates will be expected to plan, execute, and lead independently designed, peer-reviewed projects investigating the biophysics of organellar chloride transport and its physiological and pathophysiological roles in neurons. Candidates will also develop and apply advanced techniques to measure Cl dynamics and transport across organellar membranes, including electrophysiology of organelles, fluorescence-based ion imaging, and spectroscopy.
This staff scientist will also be expected to employ electrophysiology, live-cell imaging, and other methods to elucidate molecular mechanisms of chloride channels/transporters in organelles. Lastly, candidates will design and implement in vitro and in vivo experiments, analyze data, interpret results, and publish findings in high-impact journals, as well as mentor and supervise trainees, postdocs, and junior laboratory staff.
What you'll need to apply
Interested applicant should submit a cover letter (describing your research interests and how your experience aligns with this position), a current CV, a concise statement of your research interests (<2 pages), and the contact information of three professional references to Dr. Joseph Mindell at the email below.
Contact name
Joseph Mindell
Prospective applicants should have a Ph.D. in Biophysics, Neuroscience, Cell Biology, Biochemistry, Biomedical Engineering, and/or a closely related field. Applicants should also have 5 years of postdoctoral research experience with a demonstrated track record conducting independent research. First-author publications in peer-reviewed journals that demonstrate expertise in organellar biology, ion transport, or biophysical methods are highly desired.
Strong technical expertise in organellar electrophysiology or patch-clamp techniques, as well as live-cell imaging of Cl dynamics (Cl -sensitive indicators, genetically encoded sensors), ion channel/transport kinetics, and protein expression/purification is required. Proficiency in mammalian and insect cell culture, protein interaction assays, and data analysis using Python, MATLAB, R, is also required. Experience with structural methods (such as cryo-EM, X-ray crystallography) and/or computational modeling is highly desirable.
Excellent communication and collaborative skills, as well as the ability to work effectively in a multidisciplinary, team-based environment, is necessary.
U.S. citizens and permanent residents are eligible to apply.
