The Molecular Microscopy Group at the National Institute of Environmental Health Sciences is seeking a junior postdoctoral fellow to conduct independent research projects using cryo-electron microscopy, and related structural biology approaches, to study biologically important macromolecular assemblies and cellular systems.
This position is intended for an early-career scientist who has no previous postdoctoral experience and is interested in becoming an independent and highly-capable structural biologist.
This fellow will receive intensive training in cryo-EM sample preparation, data collection, image processing, structure determination, and scientific communication. Prior cryo-EM experience is welcome but not required. This fellow will work in a rich research environment supported by the NIEHS Cryo-EM Core, which provides access to a 300 keV Titan Krios G4, a 200 keV Talos Arctica, an Aquilos cryo-FIBSEM, multiple cryo-EM sample-preparation systems, and NIH high-performance and cloud-computing resources. The research program is also supported by complementary NIEHS core facilities in protein expression and purification, viral vectors, NMR, X-ray crystallography, mass spectrometry, molecular dynamics, and related areas.
Potential projects may involve the development and application of single-particle cryo-EM, cryo-electron tomography, and cryo-FIBSEM to address mechanistic questions in structural biology. We are particularly interested in a motivated early-career scientist with the drive, discipline, curiosity, and collaborative spirit needed to grow rapidly as an independent researcher.
What you'll need to apply
Applicants should email a cover letter, complete CV, and the names of three professional references to Dr. Mario Juan Borgnia at the email below.
Contact name
Mario Juan Borgnia
Prospective applicants must have a Ph.D., M.D., or equivalent doctoral degree in structural biology, biochemistry, biophysics, molecular biology, cell biology, or a related field. Consistent with NIH postdoctoral eligibility, candidates should be within five years of receiving their doctoral degree at the time of appointment.
Applicants should have a strong interest in advanced training in cryo-EM, structural biology, and the application of molecular microscopy methods to important biological questions. A strong foundation in structural biology, biochemistry, biophysics, molecular biology, cell biology, or quantitative analysis is also desirable. Computational skills, including experience with programming, quantitative analysis, and Linux-based computing environments, are a plus.
Excellent written and oral communication skills, a strong record of accomplishment, scientific curiosity, independence, and the ability to work as part of a collaborative team are essential.
U.S. citizens and permanent residents are eligible to apply.
