The Laboratory of Dr. Greg Landry in the Department of Pharmaceutical Sciences within the School of Pharmacy in Boston, MA seeks a Research Technician to investigate the mechanisms of target organ toxicities of diethylene glycol and ethylene glycol in cell/tissue culture & rodent models for antidote development and risk assessment purposes.
We are looking for an extremely detailed-oriented individual who has experience growing and maintaining immortalized, primary, and transgenic cell lines such as human SH-SY5Y neuroblastoma cells, Madin-Darby canine kidney (MDCK) cells, mouse TKPTS proximal tubule cells, mouse inner medullary collecting duct-2 (mIMCD-3) cells, Human Kidney-2 (HK-2) cells, primary human proximal tubule cells, etc. under proper and strenuous aseptic technique. Experience performing various toxicological, biochemical, and molecular biological assays, techniques, etc. is also required, including but not limited to all cell death biomarker assays, western blotting, qPCR, enzyme function/ inhibition assays, etc. In addition, the individual should also have significant experience in mouse husbandry; oral gavage (proficiency required), necropsy, and tissue preparation for histopathological and metabolite analysis, and possibly future rat work. We are ideally targeting candidates looking to commit to the lab at least 1 year with the potential for additional years pending continued funding. As with all roles involving cell/tissue culture & animal work, this position will require flexible hours depending on the needs of the study. We are ideally targeting someone who is significantly independent, enthusiastic, curious, and passionate about the work that they do within a cutting-edge scientific lab.
Laboratory Research (100%)
- Grows and maintains a variety of immortalized, primary, and transgenic cell lines under proper and strenuous aseptic technique
- Responsible for being the point of contact for all laboratory instrumentation and its maintenance, especially on instruments utilized consistently for the project(s)
- Performs various toxicological, biochemical, and molecular biological assays, techniques, etc. is also required, including but not limited to all cell death biomarker assays, western blotting, qPCR, enzyme function/ inhibition assays, etc.
- Experience with statistical software for data analysis, specifically GraphPad Prism, as well as the Microsoft Office Suite
- Prepares all stock, working, and media solutions, etc. correctly and understands how to make correct concentrations of solutions based on ingredient concentrations
- Performs mouse and/or rat work such as oral gavage, husbandry, sacrificing, and tissue harvesting, as well as possible rat work; handles wild-type and possibly transgenic mouse models, such C57/Bl6 and CD-1 mouse strains, as well as rat work using Wistar, F-344, and/or Sprague-Dawley strains.
- Manages adherence to institutional biosafety and animal care and use standards and keep compliance records/logs up to date
- Attends lab meetings and planning sessions
- Accurately and effectively (daily) maintain an extremely detailed laboratory notebook
- Possesses the ability to participate and possibly lead research projects and to potentially supervise undergraduate and graduate students in the laboratory
Requirements:
Required:
- A B.S./B.A. degree in Toxicology, Pharmacology, Biological Sciences, Biochemistry, and/or equivalent.
- Previous hands-on experience and proficiency growing and maintaining healthy immortalized, primary, and transgenic cell lines under proper, strict, and strenuous aseptic technique
- Experience performing toxicological, biochemical, and molecular biological assays independently
- Previous hands-on experience, comfortability, and proficiency working with rodents in a laboratory environment, including but not limited to handling and management experience to include mouse oral gavage, blood/tissue collection, husbandry, breeding, colony management, etc.
- Strong initiative, self-motivation, and capacity for creative problem solving
- Strong multitasking skills and time management
- Ability to use good judgment in managing deadlines and responding to inquiries.
- Meticulous attention to detail with emphasis on keeping records of experiments and results.
- Strong student management potential
Physical Requirements:
- Remaining in a normal seated or standing position for extended periods of time
- Reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example being able to manipulate different laboratory equipment differently with each hand simultaneously, being able to handle a live animal with one hand and perform a technique on the animal with the other, etc.
- Exceptional communication skills using the spoken and written English word
- Ability to see and hear within normal parameters
- Ability to move about workspace
- The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer, animal cages, shelving, metabolic cages, etc.).
Compensation: N/A
Additional Details :
Apply
Please attach a cover letter and a curriculum vitae/resume. Finalist candidate(s) for this position will be subject to reference checks and a pre-employment background check as a condition of employment.
Applicants must be authorized to work for any employer in the U.S. MCPHS is unable to sponsor, or take over sponsorship of an employment Visa. MCPHS is also not an E-Verify institution.
About Us
Established in 1823, Massachusetts College of Pharmacy and Health Sciences (MCPHS) is the oldest institution of higher education in Boston, a city that is home to many of the world's top universities and healthcare institutions. We are one of the largest and most highly-ranked schools for health and life sciences, and our alumni and faculty continually distinguish themselves in healthcare settings around the globe.
MCPHS has more than 7000 students across campuses in Boston's Longwood Medical and Academic Area (LMA), downtown Worcester, MA and downtown Manchester, NH.
Our vision is to empower our Community to create a healthier, more equitable world, which we strive to achieve through our core values of integrity, community, engagement, collaboration, support, and innovation.
We offer competitive salaries and excellent benefits that include a substantial contribution toward the cost of medical, vision, and dental insurance, generous time off, retirement and pension plans, and flexible work arrangements to support work/life balance for our employees while supporting the MCPHS strategic plan.
MCPHS is an equal opportunity employer dedicated to ensuring equal opportunity for all members of the University community. We aim to recruit, develop, and retain the most skilled faculty and staff. All qualified applicants will be considered for employment.
Pay Transparency The pay range associated with this posting reflects the amount the University reasonably expects to pay for this role at this time. Salary offers are determined based on experience, skills, and qualifications as well as internal equity, market data, and pay in comparison to similarly situated employees doing comparable work.
