Associate Scientist/Scientist I, Protein Science Developability

Lila Sciences
Cambridge, MA

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Job Details

$88,000 - $144,000 a year
23 hours ago

Qualifications

Data integrity assurance
Data quality checks
Record keeping
Laboratory project records management
System troubleshooting
Protein analysis (analytical chemistry specialty)
Assay development
Biochemical laboratory techniques
Chemical separation processes
Data quality monitoring
Mass spectrometers (MS)
Cross-functional collaboration
Liquid chromatography machines
Cross-functional communication
Data analysis software

Full Job Description

Your Impact at LILA

Lila Sciences is seeking an Associate Scientist/Scientist I specializing in high-throughput protein purification and analytics to join the Protein Sciences team within the Autonomous Science Platform. In this role, you will design, optimize, and execute protein purification workflows using chromatography systems, develop and validate bioassays, and apply mass spectrometry techniques to support protein characterization across Lila's autonomous laboratory platform. You will work at the intersection of protein sciences and laboratory automation, partnering closely with AI scientists, automation engineers, and cross-functional research teams to accelerate scientific workflows. Your expertise in protein analytics, method development, and data interpretation will directly contribute to the development of Lila's Scientific Superintelligence platform.

What You'll Be Building

Design, develop, and optimize high-throughput protein purification workflows using AKTA chromatography systems (affinity, ion exchange, size exclusion) across diverse protein classes (antibodies, bi-specifics, multi-specifics, enzymes, etc.).
Perform mass spectrometry-based analyses to confirm protein identity, assess purity, and characterize post-translational modifications.
Develop and validate bioassays (binding, activity, and stability) to assess protein function and quality, ensuring assay robustness and reproducibility at scale.
Identify opportunities to improve throughput, yield, and reliability of purification and analytical methods, and drive implementation of those improvements.
Partner with automation engineers to integrate purification, bioassays, and analytical workflows into automated workcells and high-throughput platforms.
Ensure data quality, documentation, and reproducibility in all experiments; actively contribute to knowledge sharing and continuous improvement initiatives.
Collaborate with computational scientists to support data analysis pipelines, data processing, and the development of predictive models for protein characteristics.

What You'll Need to Succeed

MS in Biochemistry, Biophysics, Bioengineering, Molecular Biology, or a related field with 4+ years of relevant experience, or PhD in a related discipline with 0-2 years of postdoctoral or industry experience.
Experience operating AKTA chromatography systems for protein purification with proficiency across a wide range of chromatographic techniques (e.g. affinity, SEC, HIC, IEX, etc.), and the ability to develop, optimize, and troubleshoot purification workflows.
Hands-on experience in LC-MS techniques for protein characterization, including intact mass analysis, peptide mapping, PTM identification, and glycosylation profiling, with exposure to interpretation of complex mass spectral data and troubleshooting instrument performance.
Familiarity with assay development, optimization, and data analysis for bioassay techniques such as ELISA, AlphaLisa, SPR/BLI, and functional activity assays.
Strong laboratory data analysis, digital recordkeeping (e.g., Benchling), and collaborative scientific workflows.
Outstanding analytical and problem-solving skills with meticulous attention to data quality and reproducibility.
Effective communication skills and an eagerness to collaborate within a fast-paced, cross-functional team.

Bonus Points For

Experience working with laboratory automation platforms and high-throughput screening workflows.
Familiarity with additional protein characterization techniques such as CE-SDS, SEC-MALS or DSF.
Experience with data analysis tools (e.g., Python, R, or equivalent) and automating data workflows.

About LILA

Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves.

LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai.

Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply.

We're All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.

A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

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