The Kourembanas laboratory focuses on studying the molecular and cellular processes underlying the developmental lung injury affecting preterm infants, known as bronchopulmonary dysplasia or chronic lung disease of prematurity. A complementary active area of research in the lab is the study of stem cell-based therapies focusing on the biology and application of mesenchymal stem cell extracellular vesicles (MSC-EVs) as vectors of intercellular signaling and potent immune modulators. The Kourembanas group was first to demonstrate the effect of MSC-EVs on preventing and reversing pulmonary hypertension and neonatal hyperoxic lung injury in experimental models, paving the way for future cell-free regenerative approaches for the treatment of important diseases of the newborn infant. This research assistant position will be involved in both animal model (murine) and human monocyte tissue culture-based projects. Ideally, a successful candidate would be able to make a minimum 18-month commitment.
Key Responsibilities-
According to prescribed protocols and assigned schedules, performs a variety of routine laboratory experiments and procedures, utilizing standard laboratory equipment, recording and checking results for completeness and accuracy.
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Assists in troubleshooting procedures if experimental results are unexpected or quality of specimens is poor.
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Performs the following techniques typically required for the laboratory/study:
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Maintains records of results and methodologies in a log of work performed. Maintains equipment, lab area, and supplies in a neat professional manner.
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Sterilize and clean glassware, and prepare media and other materials using appropriate procedures.
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Inventories supplies, alerts supervisor to needed supplies, or mixes standard reagents.
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Processes order for supplies and/or animals.
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Attends courses in safety procedures for handling, storage, and disposal of biohazardous, flammable, corrosive, and toxic materials.
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Carries out all laboratory activities in compliance with applicable regulations and protocols.
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Conducts literature searches and reviews, compiling information for journals and suggesting uses for new techniques to the P.I.
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Attends courses, lectures, and conferences to further own knowledge of research and laboratory techniques, consulting with other researchers and technicians to exchange information.
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Contributes to the team within and between departments and organizations.
Minimum Qualifications
Education:
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A bachelor’s degree in STEM ideally with a focus on Immunology or Molecular Biology
Experience:-
Tissue culture and molecular biology experience necessary.
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Immunology background, murine model experience, histology and flow cytometry skills are a plus.
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Analytical skills to resolve problems that require the use of basic scientific, mathematical, statistical or technical principles.
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Ability to communicate effectively both orally and in writing.
