The Yasuda Laboratory focuses on elucidating the coordinated activity of signaling proteins that mediate the structural plasticity of dendritic spines, a form of plasticity that is critical for learning and memory. In particular, we develop novel optical sensors to measure the signaling activity of key proteins that contribute to plasticity using two-photon fluorescence lifetime imaging (2pFLIM). Our lab also develops tools to optically manipulate protein activity and label endogenous proteins, and we combine these new techniques with two-photon imaging/uncaging, electrophysiology, in vivo imaging, and biochemistry to produce high impact publications (e.g. Nature, Science, Cell, Nature Neurosci, Neuron, etc.). We encourage applications from candidates who are excited to push the boundaries of current optical approaches. Excellent communication skills and ability to work in a collaborative team setting are required.
