The department of Biology is a large, unified department with strong undergraduate degrees, nationally-ranked graduate programs, and world-class research spanning the breadth of biological questions and experimental systems – from ecosystems to microbiology and developmental biology, from evolution to cell biology, from molecular biology to systems biology, bioinformatics, and genomics. It is always an exciting time for Biology – enormous advances in global genome analysis coupled with unprecedented developments in interdisciplinary research have made the 21st century the Century of Biology. For more information about the department, you can find it here: About: Department of Biology: Indiana University Bloomington.
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The Landeta Lab in the Department of Biology at Indiana University, Bloomington is seeking a Postdoctoral Fellow. Our department is a large, unified department with world-class research spanning all levels of biological organization and diverse experimental systems. Our lab in Microbiology investigates the processes that take place in the bacterial cell envelope with emphasis into oxidative protein folding. The overarching goal for this position is to make timely progress on our NIH and CFF grants (https://reporter.nih.gov/search/kpoQKsh8Pkqp4S1_RS1-PQ/project-details/11259946), which looks for fundamental insights into novel oxidative reactions, the exported proteins that depend on disulfide bonds, the substrate specificity among thiol-disulfide oxidoreductases and finding novel inhibitors against oxidative folding. We are excited about science and looking for another positive, curious person to join our team.
Core topics to work on: (1) In vitro assays to determine inhibitor efficacy against redox membrane proteins
(2) Cysteine enrichment of DsbA substrates in E. coli and Mycobacteria using proteomics. (3) determine differences between DsbA proteins of two model organisms, E. coli and M. smegmatis (4) Establishing termini restraining for inhibitor-protein crystallography in collaboration with Prof. Weikai Li.
Other general responsibilities include: Supervising undergrads; managing general lab operations; writing up research (e.g. for our annual reports or for manuscripts); presenting findings at lab meetings, microphiles, retreats and conferences; and participating in lab meetings.
