Top 16 Medicinal chemist Jobs in Boston Ma

Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $177,000 - $278,080 a year
- Hybrid work
- Management
- Bachelor of Science
- 11+ years
- Paid holidays
- Disability insurance
14d
Senior Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance
11d
Principal Scientist, Medicinal Chemistry
C4 Therapeutics Inc —Watertown, MA
- $181,012.05 - $200,066.00 a year
- Full-time
- Management
- Doctor of Philosophy
- Senior level
Quick Apply
Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery
Sanofi —Cambridge, MA
- $100,500.00 - $145,166.66 a year
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Parental leave
Senior Engineer I, Synthetic Chemistry
Ginkgo Bioworks —Boston, MA
- $103,900 - $155,500 a year
- Full-time
- Bachelor of Science
- Mid-level
- 3 years
- Paid holidays
- Health insurance
Scientist II, Discovery Chemistry and Automation (Parallel Synthesis)
Valo Health —Lexington, MA
- $123,250 - $145,000 a year
- 6 years
- Bachelor of Science
- Bachelor's degree
- Retirement plan
Director, Medicinal Chemistry
Kymera Therapeutics —Watertown, MA
- $195,000 - $275,000 a year
- 8 years
- Doctor of Philosophy
- Mentoring
Quick Apply
AIRx, Sr. Director, Nonclinical Safety Lead
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Call employer
- Hybrid work
- 11+ years
- Business development
- Doctor of Philosophy
- Paid holidays
- Disability insurance
Toxicology Research Associate - Preclinical Safety assessment
Eurofins USA PSS Insourcing Solutions —Boston, MA
- $30 - $34 an hour
- Full-time
- Bachelor of Science
- Pass drug screening
- Mid-level
- Paid holidays
- Disability insurance
Quick Apply
12h
Senior Scientist, Oligonucleotide
CRISPR Therapeutics, Inc. —South Boston, MA
- $145,000 - $155,000 a year
- Full-time
- Presentation skills
- Doctor of Philosophy
- Mentoring
Quick Apply
Research Fellow, Chemical Biology & Proteomics
Biogen —Cambridge, MA
- $110,000 a year
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
- Employee stock purchase plan
- Paid holidays
10d
Postdoctoral Research Fellow
Massachusetts General Physicians Organization, Inc. —Boston, MA
- $70,000 - $71,750 a year
- Email
- Doctor of Philosophy
- Senior level
- Under 1 year
Quick Apply
5d
Senior Engineer III, ADME
Ginkgo Bioworks —Boston, MA
- 7 years
- Master's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
Scientist I/II, Organic Chemistry
Lila Sciences —Cambridge, MA
- $108,000 - $170,000 a year
- Doctor of Philosophy
- Senior level
- Communication skills
Quick Apply

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medicinal chemist jobs near boston ma

Director, AIRx Medicinal Chemistry

Takeda Pharmaceutical -
Boston, MA

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Job Details

$177,000 - $278,080 a year
14 days ago

Benefits

Paid holidays
Disability insurance
Health insurance
Dental insurance
Tuition reimbursement
Paid time off
Vision insurance
401(k) matching
Volunteer time off
Life insurance

Qualifications

AI models
Program management
Management
In silico prediction
AI tools proficiency
Medicinal chemistry
Pharmaceutical company experience
Pharmaceutical research experience

Full Job Description

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Director, AIRx Medicinal Chemistry

Takeda Research is constructing the Discovery Automation & Robotics (DAR) group built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and The Discovery Automation & Robotics (DAR) group.

AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models and deliver candidates to the clinic at industry leading speed and success rates.

Purpose

This is medicinal chemistry as it should be — pure design, at speed, with the best tools available. You will work at the frontier of AI-enabled molecular design: evaluating generative proposals, applying deep SAR judgment, and directing CRO synthesis to close DMTA cycles faster than any traditional discovery team. No synthetic bench. No compound store. Just expert chemistry thinking applied at maximum velocity.

The AIRx Medicinal Chemist is a seasoned drug hunter who thrives in lean, autonomous environments and is excited to work at the frontier of AI-driven drug design. Strong SAR intuition, decisiveness, and the confidence to challenge computational outputs are as important as deep chemistry expertise. We are not looking for someone who will defer to the AI. We are looking for someone who will argue with it, stress-test its proposals against hard-won SAR experience, and make better molecules because of that tension. If you have deep chemistry instinct and genuine curiosity about what generative AI can and cannot do — this is where that combination produces real impact.

Accountabilities

Design and optimize drug candidates using deep SAR intuition, multi-parameter optimization, and ADME-embedded design principles
Integrate AI/ML-generated design proposals with medicinal chemistry judgment — critically evaluating computational outputs, not simply accepting them
Partner closely with Computational Chemistry colleagues to close DMTA cycles rapidly; contribute to defining next design iterations
Provide strategic oversight of CRO synthesis programs: define compound lists, review synthetic routes, and ensure quality and delivery timelines
Embed selectivity, developability, and IP considerations into design decisions from the outset
Interpret structural biology data (X-ray, cryo-EM) in partnership with Structural Biology contacts to guide optimization
Stay current with competitive chemical matter and emerging chemistry approaches; proactively apply new methods
Contribute to AI/ML training datasets by ensuring experimental data is captured in standardized, decision-ready format

Qualifications & Competencies

PhD in medicinal chemistry or organic chemistry
10+ years of drug discovery experience with a strong track record in lead optimization and candidate nomination OR
MS with 16+ years experience, OR BS with 18+ years experience
Demonstrated expertise in SAR-driven design, ADME optimization, and multi-parameter optimization across multiple programs
Experience directing CRO-based chemistry programs including synthetic route planning; proven vendor oversight and delivery management
Working knowledge of AI/ML design tools; ability to critically interpret and challenge computational outputs
Familiarity with structure-based drug design; ability to read and apply protein-ligand structural data
Experience in one or more therapeutic areas across the Takeda Research portfolio preferred
Has operated in SWAT team, rapid-response, or focused asset team environments and knows the difference between productive urgency and firefighting — and thrives in the former

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$177,000.00 - $278,080.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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medicinal chemist jobs in boston ma

Director, AIRx Medicinal Chemistry

Senior Director, AIRx Medicinal Chemistry

Principal Scientist, Medicinal Chemistry

Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery

Senior Engineer I, Synthetic Chemistry

Scientist II, Discovery Chemistry and Automation (Parallel Synthesis)

Director, Medicinal Chemistry

AIRx, Sr. Director, Nonclinical Safety Lead

Toxicology Research Associate - Preclinical Safety assessment

Senior Scientist, Oligonucleotide

Research Fellow, Chemical Biology & Proteomics

Postdoctoral Research Fellow

Senior Engineer III, ADME

Scientist I/II, Organic Chemistry

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