Top 112 Associate principal scientist, bioconjugation Jobs in Bristol, Pa

Associate Principal Scientist, Bioconjugation
Abzena Inc. —Bristol, PA
- Full-time
- 7 years
- Doctor of Philosophy
- Travel
Quick Apply
12d
Child Care Associate Director
The Malvern School —Warrington, PA
- Full-time
- Customer service
- Mid-level
- Preschool
- Paid training
- Paid holidays
Quick Apply
13d
Associate Director, Biostatistics
Genmab —Princeton, NJ
- $156,880 - $235,320 a year
- Online Application
- Master's degree
- Databases
- Doctor of Philosophy
- Commuter assistance
- Paid parental leave
Senior Research Associate
Genmab —Princeton, NJ
- $81,600 - $122,400 a year
- Online Application
- Bachelor of Science
- Data analysis skills
- Research
- Commuter assistance
- Paid parental leave
Principal Scientist
Focus Laboratories —Cherry Hill, NJ
- $118,000 - $135,000 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Mentoring
- Health insurance
- Dental insurance
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Senior Associate Scientist I, Quality Control
WuXi Biologics —Cranbury, NJ
- $60,000 - $960,000 a year
- Weekends as needed
- Maintenance
- Mid-level
- Master's degree
Scientist, Material Sciences
Bristol-Myers Squibb —Princeton, NJ
- $100,330 - $121,571 a year
- Email
- Hybrid work
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Paid holidays
- Disability insurance
3d
Research Associate, In Vivo Analytical Development
Kite Pharma —Philadelphia, PA
- $74,715 - $96,690 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- 1 year
- Health insurance
- Dental insurance
11d
Associate Principal Scientist, Mass Spectrometry
Merck —West Point, PA
- $142,400 - $224,100 a year
- Full-time
- 5 years
- Bachelor of Science
- Analysis skills
- Paid holidays
- Health insurance
Molecular Biology Scientist/Senior Associate Scientist
Legend Biotech US —Philadelphia, PA
- $93,463 - $122,670 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Quality control
Quick Apply
Principal Scientist, Cardiovascular Translational Biomarker
Bristol-Myers Squibb —Princeton, NJ
- $135,800 - $164,563 a year
- Email
- Hybrid work
- Bachelor's degree
- Doctor of Philosophy
- Travel
- Paid holidays
- Disability insurance
Principal Scientist - ADME - Site Based, Princeton, NJ
Evotec —Princeton, NJ
- $113,900 - $154,100 a year
- Full-time
- 5 years
- Writing skills
- Doctor of Philosophy
- Commuter assistance
- Paid holidays
Associate Scientist - MSAT
USWM, LLC —Philadelphia, PA
- $70,000 - $110,000 a year
- Full-time
- Ability to walk for extended periods
- Computer literacy
- Bachelor of Science
Quick Apply
Principal Scientist, Global Downstream Production
WuXi Biologics —Cranbury, NJ
- 3 years
- Master's degree
- US work authorization
Associate Staff Scientist - Schiffner Lab
Wistar —Philadelphia, PA
- Full-time
- Mid-level
- Doctor of Philosophy
- AI
Principal Scientist, Vaccine Drug Product Development
Merck —West Point, PA
- $173,200 - $272,600 a year
- Full-time
- Bachelor of Science
- 8 years
- Bachelor's degree
- Paid holidays
- Health insurance
Postdoctoral Research Associate
Princeton University —Princeton, NJ
- Online Application
- Background check
- Computer Science
- University
Associate Scientist, Analytical Development – On-site, Philadelphia, PA
Cabaletta Bio —Philadelphia, PA
- Mid-level
- Master's degree
- Bachelor's degree
- Health insurance
- Paid time off
Senior / Principal Scientist, LCMS - ADC & Related Modalities
Abzena Inc. —Bristol, PA
- Full-time
- 5 years
- Analysis skills
- Doctor of Philosophy
Quick Apply
Associate Director Toxicology
Acadia Pharmaceuticals Inc. —Princeton, NJ
- $155,000 - $193,200 a year
- Hybrid work
- 6 years
- Bachelor of Science
- Office
- Paid parental leave
- Employee stock purchase plan

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Associate Principal Scientist, Bioconjugation

Abzena Inc. -
Bristol, PA

Quick Apply

Job Details

Full-time
12 days ago

Qualifications

Research project team leadership
Process optimization
Team leadership
Protein analysis (analytical chemistry specialty)
Biochemical laboratory techniques
Chemical separation processes
Doctor of Philosophy
Leading team collaboration initiatives
Laboratory staff supervision
GMP for research safety and compliance

Full Job Description

With extensive experience in developing biologics and bioconjugates, we offer a seamless service delivered by fully integrated teams, from early discovery to commercial manufacturing.

Forward-thinking and committed, we find the best solution and use the right technologies to design, develop and manufacture your products to ensure we get vital medicines to patients quickly and safely.

We are dedicated to quality excellence. We are driven to get better treatments to market, efficiently and responsibly by reducing timelines and delivering the highest quality products and services.

We are Abzena. More than a CDMO, we are a responsible and dedicated partner that takes care of your products from concept to patient.

The Bioconjugation Development Associate Principal Scientist is responsible for helping drive bioconjugation efforts in discovery and process development to support Abzena Bristol’s scientific and manufacturing operations. This includes conjugation screening, conjugation reaction optimization, downstream purification development and scale-up activities; mentorship, training and potential management of direct reports; take lead on projects and client-facing meetings and updates; support sales and proposals process by providing technical and SME support including the design and costing of project activities as needed.

Responsibilities

Drive and support technical execution of R&D bioconjugation activities and successfully deliver client and internal company projects from initial assignment to completion.

Hands-on execution of chromatographic purifications (affinity, hydrophobic interaction (HIC), and ion exchange chromatography (IEX)), membrane filtrations (normal and tangential flow filtrations (TFF)), buffer and solution preparation, conjugation reaction work-up.

Perform, develop and optimize bioanalytical characterization (HPLC, UPLC, LC-MS, SEC-MALS, colorimetric assays, etc.) of conjugate products.

Leverage expertise to aid in the design and management of project plans and conjugation strategies with a focus on improving project completion times.

Serve independently as bioconjugation technical lead and subject-matter expert (SME) for internal and external project communications.

Training, mentorship, and management of assigned reports.

Monitor and assess direct report(s) performance through regular tracking of department based KPIs.

SME and technical support for sales and proposals teams, including client facing scoping calls, bid defenses and proposal generation.

Help lead technical transfer of bioconjugation processes to Abzena’s bioconjugation manufacturing group including training, risk assessment, gap assessments and batch record writing and review according to ICH and FDA guidelines.

Authoring and reviewing relevant documentation including laboratory notebooks, process development reports, protocols, batch records, SOPs, technical presentations.

Provide on-the-floor SME and technical support during complex manufacturing operations as needed.

Coordinate activities with QA/QC and Management for development of tox and GLP batches.

Maintain strong technical understanding of advancements in bioconjugation/bioprocessing through literature searches and review.

Participate in the hiring process by screening and interviewing candidates.

Operate to the highest ethical and moral standards.

Comply with Abzena's policies and procedures.

Communicate effectively with clients, supervisors, colleagues and staff.

Participate effectively as a team player in all aspects of Abzena's business.

Adhere to quality standards set by regulations and Abzena policies, procedures, and mission.

Perform other duties as assigned.

Contribute to assigned laboratory operations including instrument and equipment operations, material shipment preparation, consumables procurement.

Qualifications

A PhD in chemistry, bioorganic chemistry, chemical biology or similar with >7 years industry experience in biotherapeutic conjugate development or bioconjugation.

Demonstrated experience applying and optimizing state-of-the-art bioconjugation or bioorthogonal chemistry techniques to produce conjugates (ADCs, AOCs/ARCs, PDCs, DACs, etc.) at various scales (mg-gram scales)

Thorough, hands-on experience with small-scale and preparative chromatography systems (AKTA Pilot, AKTA Ready, AKTA Explorer, etc.) for purification of biomacromolecules (antibodies, fusion proteins, carrier proteins, viruses, viral vectors, or other biologics).

Expertise in normal flow filtrations and tangential flow filtrations (TFF or UF/DF).

Knowledge of strategies for the optimization of bioprocesses and experimental design (DoE).

Expertise with quantitative determination of scalable process parameters for normal flow filtrations, tangential flow filtrations, and preparative chromatographic separations.

Knowledge of cGMP manufacturing operations and GxP principles.

Experience with protein bioanalytical techniques (HPLC, LC-MS, CE-SDS, UV-spectrophotometry, etc.)

Experience with large scale bioprocess equipment (pallet tanks, pumps, biowelders, biosealers, bio-rockers, single-use assemblies).

Prior leadership experience required.

Travel between Abzena sites (Bristol PA, San Diego CA, Cambridge UK) as needed.

Physical Requirements

Ability to stand for 1-2 hours at a time, sit for 2 to 3 hours at a time.

Frequently lift and or move objects up to 30 pounds.

Stand/walk during entire length of shift.

Use arms, hands and fingers to handle, feel or reach.

Ability to climb, balance, stoop, kneel, crouch, or crawl.

Visual abilities including near and far sight, color, peripheral vision, depth and ability to focus

FLSA: Exempt

Abzena is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

This policy applies to all employment practices within our organization, including hiring, recruiting, promotion, termination, layoff, recall, leave of absence, compensation, benefits, and training.

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Refine Your Search

associate principal scientist, bioconjugation jobs in bristol, pa

Associate Principal Scientist, Bioconjugation

Child Care Associate Director

Associate Director, Biostatistics

Senior Research Associate

Principal Scientist

Senior Associate Scientist I, Quality Control

Scientist, Material Sciences

Research Associate, In Vivo Analytical Development

Associate Principal Scientist, Mass Spectrometry

Molecular Biology Scientist/Senior Associate Scientist

Principal Scientist, Cardiovascular Translational Biomarker

Principal Scientist - ADME - Site Based, Princeton, NJ

Associate Scientist - MSAT

Principal Scientist, Global Downstream Production

Associate Staff Scientist - Schiffner Lab

Principal Scientist, Vaccine Drug Product Development

Postdoctoral Research Associate

Associate Scientist, Analytical Development – On-site, Philadelphia, PA

Senior / Principal Scientist, LCMS - ADC & Related Modalities

Associate Director Toxicology

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