Top 35 Scientist sr Jobs in Columbus

Senior Scientist, Developability & Preformulation
Sarepta Therapeutics —Columbus, OH
- $118,000 - $147,500 a year
- Full-time
- Engineering
- Doctor of Philosophy
- US work authorization
Sr Associate Finance
Amgen —New Albany, OH
- Mid-level
- Bachelor's degree
- In-person
- Disability insurance
- Health insurance
Senior Scientist
Bob Evans Foods —New Albany, OH
- Full-time
- 5 years
- Bachelor's degree
- Senior level
R&D Formulation Sr Scientist I
American Regent, Inc. —New Albany, OH
- Full-time
- Microsoft Excel
- 5 years
- Master's degree
Lab Tech Sr.
Experis —Columbus, OH
- $20 - $22 an hour
- Contract
- Mid-level
- US work authorization
- 1 year
Quick Apply
12d
Senior Reporting and Analytics Analyst
The Ohio State University —Columbus, OH
- Full-time
- Hybrid work
- Background check
- Pass drug screening
- Mid-level
11d
Senior Project Manager - Psychiatry
The Ohio State University —Columbus, OH
- Full-time
- Background check
- Management
- Psychiatry
Research Senior Technician
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Pass drug screening
- Mid-level
R&D Senior Innovation Chemist
Bright Innovation Labs —New Albany, OH
- 8 hour shift
- Microsoft Excel
- Microsoft Outlook
- English
Quick Apply
Senior Research Tech-Immunology and Rheumatology
The Ohio State University Wexner Medical Center —Columbus, OH
- Part-time
- Background check
- Pass drug screening
- Mid-level
- On-the-job training
Sr. Regulatory Toxicologist
The Scotts Miracle-Gro Company —Marysville, OH
- $87,600 - $103,100 a year
- Full-time
- Hybrid work
- OSHA
- 5 years
- Writing skills
- Health insurance
- Dental insurance
Research Senior Technician - Pathology
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Pass drug screening
- Mid-level
3d
Research Senior Associate & Medical Lab Science Course Support – Health and Rehab Sciences
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Blood sampling
- Pass drug screening
- Health insurance
- Dental insurance
Research Senior Associate-Comprehensive Cancer Center
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Doctoral degree
- Pass drug screening
Research Senior Technician - Molecular Medicine & Therapeutics
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Pass drug screening
- Mid-level
IGM Bioinformatics Scientist Senior
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Computer Science
- 5 years
- Ability to climb stairs
Research Senior Technician - Comprehensive Cancer Center
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Pass drug screening
- Mid-level
Research Senior Associate
The Ohio State University —Columbus, OH
- Full-time
- Background check
- Pass drug screening
- Master's degree
Research Senior Technician- Microbial Infection and Immunity
The Ohio State University Wexner Medical Center —Columbus, OH
- Full-time
- Background check
- Pass drug screening
- Mid-level
Ecological Senior Project Manager
Civil & Environmental Consultants, Inc. —Columbus, OH
- Full-time
- 11+ years
- Master's degree
- Bachelor's degree
- Profit sharing
- Disability insurance
2d

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Senior Scientist, Developability & Preformulation

Sarepta Therapeutics -
Columbus, OH

Apply Now

Job Details

Full-time
$118,000 - $147,500 a year

Qualifications

Drug development research projects
Laboratory experiment design
Stability testing
Biochemistry
Data visualization software proficiency
Chemical Engineering
Developing new product formulations
Handling proteins
Stability studies in drug product development
Engineering
Design of experiments
Protein analysis (analytical chemistry specialty)
Biomedical Engineering
Formulation chemistry
Technical report writing
Chemical scale-up projects
Biochemical Engineering
Collaboration with product development teams
Doctor of Philosophy
Scientific protocols
Technology transfer (scale-up process)
Master of Science
Pharmaceutical analysis
Engineering research
Capillary electrophoresis
Mass spectrometers (MS)
Chemistry, manufacturing & controls
Collaboration with manufacturing teams
Regulatory submission editing and review
Research assistant mentoring

Full Job Description

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

Physical and Emotional Wellness
Financial Wellness
Support for Caregivers

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us

The Importance of the Role

The Early Research and Process Development (ERPD) group is seeking a Senior Scientist with deep expertise in biologics preformulation and developability assessment, with a focus on proteins, antibodies, and antibody-oligonucleotide conjugates (AOCs). This individual will be responsible for assessing the developability of lead molecules through comprehensive evaluations, including biophysical characterization, forced degradation, and short-term, long-term, and in-use stability studies.

The successful candidate will leverage high-throughput formulation tools and workflows to characterize product stability across a broad range of conditions, including process buffers, excipients, concentrations, hold times, and temperatures. In collaboration with Analytical Development, the candidate will help define quality attributes and implement stability-indicating assays appropriate for early-stage programs. The Senior Scientist will also consider route-of-administration factors, such as subcutaneous delivery, during early formulation assessments (e.g., stability and viscosity at high concentrations, potential enabling approaches).

This role requires strong cross-functional engagement, working closely with Upstream and Downstream Process Development, High-Throughput Automation, Nonclinical Manufacturing, and CMC Drug Substance/Drug Product teams to foster a collaborative environment that enables the advancement of robust and scalable manufacturing processes. The Senior Scientist will provide formulation guidance to research, pilot-scale, and commercial-scale manufacturing groups generating scientifically rigorous data packages to inform preclinical and early clinical development and enable downstream CMC strategy for Sarepta’s genetic therapy engine.

Sarepta provides a creative culture that invites you to be the best that you can be and is committed to making a difference in patient’s lives. Join us at the Genetic Therapy Center of Excellence here in Easton, Ohio.

The Opportunity to Make a Difference

Plan and execute formulation experiments to assess and optimize the stability of key intermediates and final products throughout the manufacturing process.
Establish developability profiles for candidate molecules, incorporating considerations for route-of-administration.
Identify formulation-relevant critical quality attributes for key intermediates and drug product candidates, and guide the development of stability-indicating assays to monitor them.
Provide expert guidance on formulation technologies and instrumentation to support informed decision-making.
Offer product handling guidance to cross-functional teams.
Prepare and review methods, protocols, and technical reports for regulatory submissions or technology transfer.
Train and mentor Research Associates in process design, experimental execution, troubleshooting, and data interpretation.

More about You

Degree in Biochemistry, Biochemical Engineering, Bioengineering, or Chemical Engineering Ph.D. with 4 years of biologics formulation experience, or M.S. with

- 9 years.
- Experience with AOCs or antibody-drug conjugates (ADCs) is a plus.
Proven technical expertise in protein formulation technologies (e.g., Unchained Labs Big Tuna/Big Kahuna/Junior, Sartorius AMBR Crossflow, Pendotech 5TFF, Repligen KR2i, etc.).
Expertise in stability and analytical assays to monitor product quality, including SEC, RP, CE-SDS, cIEF, DLS, DSF, MALS, and mass spectrometry.
Experience with high-concentration formulation challenges (e.g., viscosity mitigation strategies, excipient screening, protein-protein interaction understanding)
Experience applying Design of Experiments (DoE) principles to formulation development is a plus.
Track record of cross-functional collaboration and providing scientifically informed guidance to internal and external teams.
Proficiency in statistical or data analysis tools (e.g., JMP, GraphPad, SigmaPlot) is a plus.
Prior experience in therapeutic protein discovery or biochemistry research.
Excellent written and verbal communication skills.

What Now?

We’re always looking for solution-oriented, critical thinkers.

So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

#LI-Onsite

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This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $118,000 - $147,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

Apply Now

Refine Your Search

scientist sr jobs in columbus

Senior Scientist, Developability & Preformulation

Sr Associate Finance

Senior Scientist

R&D Formulation Sr Scientist I

Lab Tech Sr.

Senior Reporting and Analytics Analyst

Senior Project Manager - Psychiatry

Research Senior Technician

R&D Senior Innovation Chemist

Senior Research Tech-Immunology and Rheumatology

Sr. Regulatory Toxicologist

Research Senior Technician - Pathology

Research Senior Associate & Medical Lab Science Course Support – Health and Rehab Sciences

Research Senior Associate-Comprehensive Cancer Center

Research Senior Technician - Molecular Medicine & Therapeutics

IGM Bioinformatics Scientist Senior

Research Senior Technician - Comprehensive Cancer Center

Research Senior Associate

Research Senior Technician- Microbial Infection and Immunity

Ecological Senior Project Manager

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