Top 14 Senior engineer full stack Jobs in Columbus

Senior AI Full stack Software Engineer
McKesson —Columbus, OH
- $131,000 - $218,300 a year
- Computer science
- Azure
- Computer Science
- Wellness program
- Employee stock purchase plan
Senior Machine Learning Engineer - Generative AI & Full-Stack Applications
CVS Health —Columbus, OH
- $83,430 - $222,480 a year
- Full-time
- 3 years
- High school diploma or GED
- Bachelor's degree
- Health insurance
- Dental insurance
Senior Full Stack Developer
Huntington Bank —Columbus, OH
- $70,000 - $140,000 a year
- Full-time
- Customer service
- Office
- 3 years
- Wellness program
- Paid holidays
Senior .NET Full Stack Developer
eBusiness Solutions Inc. —Columbus, OH
- $51 - $57 an hour
- Background check
- Azure
- English
Quick Apply
Senior Software Engineer
The Piada Group —Columbus, OH
- $120,000 - $180,000 a year
- Weekends as needed
- Hybrid work
- Background check
- Computer science
- 6 years
Quick Apply
Senior Agentic AI Software Engineer
Bread Financial —Columbus, OH
- $133,500 - $278,200 a year
- Full-time
- Hybrid work
- Computer science
- Computer Science
- Office
- Paid parental leave
- Paid holidays
2d
Senior Full Stack IoT Software Developer - Cardio Partners - Dublin, OH
Sarnova —Dublin, OH
- Full-time
- 7 years
- Computer Science
- Software troubleshooting
- 401(k)
Quick Apply
Manager of Software Engineering - Sr AWS/Full Stack Java Developer
JPMorganChase —Columbus, OH
- Full-time
- 5 years
- Java
- AWS
- Health insurance
- Tuition reimbursement
Java Developer - Senior
Huntington Bank —Columbus, OH
- Full-time
- Computer Science
- System design
- Office
Deloitte Cyber Forward Deployed Engineer/Senior Consultant
Deloitte —Columbus, OH
- $113,100 - $208,300 a year
- Full-time
- Azure
- Computer Science
- AWS
Senior Software Engineer
TaxPlanIQ —United States
- $100,000 - $140,000 a year
- Email
- Remote
- Background check
- System design
- Java
- Health insurance
- Dental insurance
Quick Apply

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Senior Machine Learning Engineer - Generative AI & Full-Stack Applications
CVS Health —Columbus, OH
This is an experienced individual-contributor role focused on evaluating, documenting, building and scaling GenAI and AI-powered capabilities, contributing to…
$83,430 - $222,480 a year

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Senior AI Full stack Software Engineer
McKesson —Columbus, OH
Experienced in creating custom AI agents or spec-driven tools. McKesson has become aware of online recruiting-related scams in which individuals who are not…
$131,000 - $218,300 a year
Senior Machine Learning Engineer - Generative AI & Full-Stack Applications
CVS Health —Columbus, OH
This is an experienced individual-contributor role focused on evaluating, documenting, building and scaling GenAI and AI-powered capabilities, contributing to…
$83,430 - $222,480 a year

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Senior AI Full stack Software Engineer

McKesson -
Columbus, OH

Apply Now

Job Details

$131,000 - $218,300 a year

Benefits

Wellness program
Employee stock purchase plan
Health insurance
Dental insurance
401(k)
Flexible spending account
Tuition reimbursement
Paid time off
Vision insurance
Flexible schedule

Qualifications

AI models
Software engineering
Node.js
Tooling
Regulatory compliance
Generative models
AI platforms (beyond public GPTs)
Prompt engineering
IT experience within healthcare
Developing large-scale AI models
Natural language processing
Health information regulatory compliance
Developing and maintaining backend systems
Web applications
Model training
Medical imaging
Benchmarking
Machine learning libraries
Model evaluation
Generative AI

Full Job Description

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

We are seeking a highly skilled and experienced Senior AI Full Stack Software Engineer to join our innovative team at CMM. This role involves designing, developing, and deploying end-to-end AI-powered solutions, from robust backend services to intuitive user interfaces, to enhance our healthcare and decision-making platforms.

Key Responsibilities

Lead AI-Driven Healthcare Solutions: Design and deploy AI applications that support decision-making, patient engagement, and operational efficiency.
Integrate AI into EHRs and Clinical Systems: Build scalable systems that incorporate LLMs, voice/image recognition, and document parsing into existing healthcare IT infrastructure.
Develop and Optimize Data Pipelines: Ensure secure, HIPAA-compliant data pipelines for training and deploying AI models using structured and unstructured healthcare data (e.g., clinical notes, imaging, lab results).
Model Evaluation and Compliance: Apply rigorous evaluation metrics (e.g., sensitivity, specificity, AUC-ROC) and ensure models meet regulatory and ethical standards.
Mentor and Lead: Guide junior engineers and contribute to the strategic direction of AI initiatives within the organization.
Rapid AI prototyping and iteration with product representatives to vet multiple concepts

Minimum Qualifications

10+ years of software engineering experience, with 4+ years in AI/ML development.
B.S. degree in Computer Science or related engineering discipline, or equivalent experience

Critical Skills

2+ years of experience building AI solutions in healthcare or life sciences.
Deep understanding of healthcare data standards (e.g., HL7, FHIR) and compliance frameworks (e.g., HIPAA, GDPR).
Healthcare AI Expertise: Proven ability to build AI models for clinical NLP, medical imaging, patient risk stratification, and care personalization.
LLM & RAG Systems: Skilled in building retrieval-augmented generation systems using tools likePydantic, Semantic Kernel,LangChain,LlamaIndex, and vector databases.
Experienced in creating custom AI agents or spec-driven tools.
Experience writing skills for Claude, Copilot, Codex etc.
Prompt Engineering & Optimization: Advanced techniques for prompt tuning, caching, and benchmarking.
Full Stack Development: Proficiency in Python, Node.js, and modern web frameworks.

Preferred Skills

Cloud & DevOps: Experience with secure cloud environments (AWS/GCP/Azure), containerization (Docker, Kubernetes), and CI/CD pipelines.
AI Tooling: Familiarity with OpenAI, Hugging Face,PyDanticAI, TensorFlow,PyTorch, and healthcare-specific AI libraries.
Communication & Leadership: Ability to communicate complex AI concepts to clinical and executive stakeholders and lead cross-functional teams.
Experience mentoring and developing juniors in development an AI concepts/best practices.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson,

Our Base Pay Range for this position

$131,000 - $218,300

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.

McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) [email protected] or (Canada) [email protected]. Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!

Benefits

Coverage you can rely on
- Medical, Dental, and Vision
- Health Spending Accounts
- Flexible Spending Accounts
Benefits that go beyond your base pay
- 401(k) (U.S.)
- Pension (Canada)
- Employee Stock Purchase Plan
Support for total well-being
- Mental Health Programs
- Flexible Schedules
- Paid Time Off
- Wellness Program
- Education Reimbursement
- Volunteer Opportunities
- Flexible Work Environment
A culture powered by belonging

By fostering a culture of belonging, we advance our goal of being the best place to work in healthcare—connecting the right talent to the right roles to solve our most critical challenges.

Apply Now

Refine Your Search

senior engineer full stack jobs in columbus

Senior AI Full stack Software Engineer

Senior Machine Learning Engineer - Generative AI & Full-Stack Applications

Senior Full Stack Developer

Senior .NET Full Stack Developer

Senior Software Engineer

Senior Agentic AI Software Engineer

Senior Full Stack IoT Software Developer - Cardio Partners - Dublin, OH

Manager of Software Engineering - Sr AWS/Full Stack Java Developer

Java Developer - Senior

Deloitte Cyber Forward Deployed Engineer/Senior Consultant

Senior Software Engineer

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