Top 24 Principal data Jobs in Maryland

Principal Data Scientist
BULLFROG AI MANAGEMENT LLC —Gaithersburg, MD
- $175,000 - $215,000 a year
- Full-time
- Remote
- Computer Science
- 5 years
- Databases
- Paid holidays
- Disability insurance
Quick Apply
Senior Data Analyst Principal
General Dynamics Information Technology —Gaithersburg, MD
- $142,792 - $167,900 a year
- Hybrid work
- Office
- SQL
- Analysis skills
- Paid holidays
- 401(k) matching
Principal Data Engineer
Leidos —Bethesda, MD
- $131,300 - $237,350 a year
- Full-time
- Azure
- Bachelor of Science
- Java
- Paid holidays
- Paid time off
Principal Knowledge & Data Architect
Howard Hughes Medical Institute —Chevy Chase, MD
- $174,770.40 - $284,001.90 a year
- Full-time
- System design
- Office
- 8 years
- Health insurance
- Retirement plan
4h
Principal Data Solutions Architect
Constellation Energy Generation, LLC. —Baltimore, MD
- $139,200 - $208,800 a year
- Full-time
- Master's degree
- Analysis skills
- Bachelor's degree
- Employee stock purchase plan
- Paid holidays
Principal Data Scientist
Leonardo DRS —Germantown, MD
- $134,332 - $181,349 a year
- Azure
- 11+ years
- SQL
- Paid parental leave
- Health savings account
11d
Principal Data Management Analyst
Northrop Grumman —Linthicum Heights, MD
- $89,900 - $134,900 a year
- Overtime
- Microsoft Excel
- Office
- Master's degree
- Paid holidays
- Disability insurance
6d
Principal Software, Data, and AI Engineer
The MITRE Corporation —Aberdeen, MD
- Full-time
- Hybrid work
- 5 years
- System design
- Windows
Principal Marketing Scientist
GEICO —Bethesda, MD
- $115,000 - $230,000 a year
- Full-time
- Marketing
- Bachelor of Science
- SQL
- Health insurance
- Tuition reimbursement
Principal Data Scientist
JLG —Frederick, MD
- $118,700 - $211,300 a year
- Full-time
- Azure
- Oracle
- Computer Science
6d
Principal Senior Data Architect
Nyla Technology Solutions —Annapolis Junction, MD
- $205,000 - $242,000 a year
- 8 hour shift
- Computer Science
- Java
- AWS
- Loan repayment program
- Health insurance
Quick Apply
Principal Data Flow Engineer
Leidos —Annapolis Junction, MD
- $154,050 - $278,475 a year
- Full-time
- Engineering
- System design
- 11+ years
- Paid holidays
- Paid time off
Principal Data Scientist
Power3 Solutions —Fort Meade, MD
- Computer science
- Computer Science
- 11+ years
- Health insurance
- Dental insurance
Data Scientist, Principal (DCO) Senior
Gormat —Annapolis Junction, MD
- Full-time
- Windows
- 3 years
- Master's degree
Quick Apply
11d
Principal AI/ML-Driven Data Scientist
Nyla Technology Solutions —Annapolis Junction, MD
- $149,000 - $176,000 a year
- 8 hour shift
- Master's degree
- SQL
- Bachelor's degree
- Loan repayment program
- Health insurance
Quick Apply
Big Data Software Engineer-Principal
NetSage —Annapolis Junction, MD
- Computer Science
- Bachelor of Science
- 11+ years
Quick Apply
4d
Principal Software/Data Engineer
Power3 Solutions —Laurel, MD
- Computer science
- Computer Science
- Engineering
- Health insurance
- Dental insurance
(Principle) Data Scientist (III/IV/V) – Sensor Analytics & Data Fusion
WGS Systems —Frederick, MD
- $115,000 - $230,000 a year
- Full-time
- Computer Science
- Master's degree
- AWS
Space RADAR Data Processing - Principal/Sr Principal Engineer Systems
Northrop Grumman —Linthicum Heights, MD
- $105,400 - $196,700 a year
- Overtime
- Computer Science
- 5 years
- Bachelor of Science
- Paid holidays
- Disability insurance
Principal Software/Data Engineer
Themis Insight —Laurel, MD
- Full-time
- Computer science
- Computer Science
- Engineering
- Health insurance
- Dental insurance
Quick Apply

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Principal Data Scientist

BULLFROG AI MANAGEMENT LLC
Gaithersburg, MD

Quick Apply

Job Details

Full-time
$175,000 - $215,000 a year

Benefits

Stock options
Paid holidays
Disability insurance
Health insurance
Dental insurance
Paid time off
Parental leave
Vision insurance

Qualifications

Machine intelligence
Pharmaceutical company experience
AI implementation
Clinical data analysis
Bioinformatics data analysis
Technical Proficiency
Python
Cross-functional communication

Full Job Description

Description:

About BullFrog AI

BullFrog AI (NASDAQ: BFRG) is a computational biology company spun out of the Johns Hopkins Applied Physics Laboratory. We sit at the intersection of AI and drug discovery, building platforms that help pharmaceutical and biotech companies make better, faster decisions across the drug development lifecycle:

bfPREP™ — biology-aware data harmonization that unlocks the value trapped in fragmented, multi-site clinical and omics datasets
bfLEAP™ — causal AI analytics for patient subgroup discovery, biomarker identification, and drug target prioritization
bfARENAS™ — structured multi-criteria decision support for high-stakes portfolio, indication, and go/no-go decisions

The Role

Help turn complex biomedical and clinical data into defensible decisions for drug discovery and development.

BullFrog AI is seeking an exceptional Principal Data Scientist with a strong background in biomedical analytics. This is a senior individual contributor role that combines client-facing project leadership with direct contributions to BullFrog’s in-house platform — spanning target discovery, patient subtyping, and multimodal data analysis.

Day-to-day work is client-dependent, with each engagement bringing a different analytical challenge. You will be expected to lead from execution and bring scientific rigor, technical depth, and clear communication to every project.

What You’ll Do

Client Engagement & Project Leadership

Own end-to-end analytical workstreams across target discovery, patient subtyping, and multimodal data exploration
Translate complex data science findings into clear, actionable insights for non-technical stakeholders and senior leadership
Collaborate effectively with distributed, remote teams to ensure seamless communication and on-time delivery

Technical Delivery

Design, implement, and optimize AI/ML models using diverse healthcare data types, including omics, claims, and EHR
Conduct multi-omic analyses such as RNA-seq differential expression, clustering, genomic association analysis, and biomarker discovery
Implement NLP and LLM solutions tailored to life sciences datasets
Contribute to the development and refinement of BullFrog’s in-house platform capabilities

Requirements:

What We’re Looking For

Education

Advanced degree (MS or PhD) in a quantitative field — biology, computer science, engineering, or related

Experience

5+ years of post-graduate experience in life sciences analytics in pharma, biotech, or consulting
Demonstrated proficiency in Python; production-quality code in a research or commercial environment
Hands-on experience with major healthcare data types — omics data required; claims and EHR experience strongly preferred
Hands-on experience applying LLMs or NLP to real analytical workflows, ideally biomedical or clinical text extraction, summarization, evaluation, or retrieval
Proven track record of collaborating effectively with remote teams
Must be legally authorized to work in the United States

Desired Skills

Prior experience in multi-modal analysis with deep learning
Causal inference experience — a significant differentiator for this role
NLP/LLM expertise applied to life sciences and healthcare text
Strong foundation in data engineering and databases
Experience with graph-based approaches: feature engineering, ML, and visualization
Cloud platform experience, particularly AWS or Google Cloud

Who Will Thrive Here

Intellectually versatile — energized by moving across problem types, data modalities, and scientific domains
Client-ready — comfortable presenting to and partnering with senior scientific and business stakeholders
Independently driven — able to scope, execute, and deliver complex analyses without heavy oversight
Scientifically rigorous — you hold your work to a publication-quality standard even in a commercial environment
Collaborative by default — remote-first is second nature; you communicate proactively and close loops

What We Offer

Base salary range: $175,000 - $210,000 per year, based on level of education, years of relevant experience, skills, and location. This role is eligible for performance bonus and equity/stock options, subject to company and plan terms. Benefits include medical, dental, and vision from day one, short-term disability, 401(k) from first paycheck, 15 days PTO, 11 paid holidays annually, and maternity and paternity leave.

BullFrog AI is an equal opportunity employer. We are committed to building a diverse team that reflects the communities and patients our work ultimately serves.
Advancing medicine through artificial intelligence.

Quick Apply

Refine Your Search

principal data jobs in maryland

Principal Data Scientist

Senior Data Analyst Principal

Principal Data Engineer

Principal Knowledge & Data Architect

Principal Data Solutions Architect

Principal Data Scientist

Principal Data Management Analyst

Principal Software, Data, and AI Engineer

Principal Marketing Scientist

Principal Data Scientist

Principal Senior Data Architect

Principal Data Flow Engineer

Principal Data Scientist

Data Scientist, Principal (DCO) Senior

Principal AI/ML-Driven Data Scientist

Big Data Software Engineer-Principal

Principal Software/Data Engineer

(Principle) Data Scientist (III/IV/V) – Sensor Analytics & Data Fusion

Space RADAR Data Processing - Principal/Sr Principal Engineer Systems

Principal Software/Data Engineer

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